Fuqiang Liu

Dysregulation of mineral metabolism: association of albumin-corrected calcium and vitamin D with diabetic kidney disease in type 2 diabetes—a cross-sectional study

Qiong Ma, Xue Li, Lin Liu, Fuqiang Liu et autres

Disturbances in calcium (Ca), vitamin D, and electrolyte balance have been implicated in diabetic kidney disease (DKD), yet existing evidence remains inconsistent. Moreover, the role of albumin-corrected Ca—a more accurate measure of biologically active Ca in patients with frequent hypoalbuminemia—remains poorly defined …

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Diagnostic Efficacy of Histology Combined with Single Cytology for Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Solid Pancreatic Lesions: A Retrospective Single-Center Study

Fuqiang Liu, Lina Ren, Qin Lu, Ling Xiao et autres

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BRD4 Signaling Maintains the Differentiated State of β Cells

Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun et autres

In diabetes, pancreatic β cells degenerate from their mature differentiated state to a dedifferentiated state. BRD4 plays a pivotal role during embryogenesis and cancer development, but its function in modulating β-cell differentiation remains unknown. In this study, multiple models including calorie restriction …

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Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian et autres

Adrenal incidentalomas (AIs) are commonly detected endocrine lesions, identified during imaging for unrelated conditions. These lesions exhibit considerable heterogeneity and diverse clinical outcomes. This study employed single-cell RNA sequencing to investigate tumorigenic characteristics of AIs, including non-functional adrenocortical adenomas, Conn's syndrome, and …

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Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling

Jia Song, Lingshu Wang, Liming Wang, Xinghong Guo et autres

Dysregulation of α cells results in hyperglycemia and hyperglucagonemia in type 2 diabetes mellitus (T2DM). Mesenchymal stromal cell (MSC)-based therapy increases oxygen consumption of islets and enhances insulin secretion. However, the underlying mechanism for the protective role of MSCs in α-cell mitochondrial …

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Mesenchymal Stem Cells Ameliorate Mitochondrial Dysfunction in α - cells and Hyperglucagonemia in type 2 Diabetes via SIRT1/FoxO3a Signaling

Jia Song, Lingshu Wang, Xinghong Guo, Qin He et autres

Abstract Background: Dysregulation of α-cells results in hyperglycemia and hyperglucagonemia in type 2 diabetes mellitus (T2DM). Mesenchymal stem cell (MSC)-based therapy increases oxygen consumption of islets and enhances insulin secretion. However, the underlying mechanism for the protective role of MSCs in α- …

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Mesenchymal stem cell-conditioned medium alleviates high fat-induced hyperglucagonemia via miR-181a-5p and its target PTEN/AKT signaling

Jia Song, Qin He, Xinghong Guo, Lingshu Wang et autres

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Efficacy of once‐daily glucagon‐like peptide‐1 receptor agonist lixisenatide as an add‐on treatment to basal insulin in Asian and white adults with type 2 diabetes mellitus: An individual‐level pooled analysis of phase III studies

Fuqiang Liu, Yuan Liu, Minzhi Liu, Guangyu Wu et autres

AIMS/INTRODUCTION: The prevalence and pathophysiological background of type 2 diabetes mellitus vary across ethnicities, and can affect treatment responses. Adding lixisenatide to basal insulin (BI) in type 2 diabetes mellitus patients has shown improvements in glycated hemoglobin (HbA1c) and postprandial glycemic (PPG) …

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Risk factors for mortality in hemodialysis patients with COVID-19: a systematic review and meta-analysis

Fengping Wang, Guangyu Ao, Yushu Wang, Fuqiang Liu et autres

New evidence from studies on risk factors for mortality in hemodialysis (HD) patients with COVID-19 became available. We aimed to review the clinical risk factors for fatal outcomes in these patients. We performed meta-analysis using the PubMed, EMBASE, and Cochrane databases. A …

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Additional file 3 of Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation

Qin He, Jia Song, Cui Chen, Jinbang Wang et autres

Additional file 3.

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Additional file 2 of Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation

Qin He, Jia Song, Cui Chen, Jinbang Wang et autres

Additional file 2.

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Poor Control of Plasma Triglycerides Is Associated with Early Decline of Estimated Glomerular Filtration Rates in New-Onset Type 2 Diabetes in China: Results from a 3-Year Follow-Up Study

Chuan Wang, Lingshu Wang, Kai Liang, Fei Yan et autres

OBJECTIVE: Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease (ESRD). Even after strict control of obesity, hyperglycemia, and hypertension, some patients still progress rapidly. Previous studies suggested diabetic dyslipidemia might be one of the factors responsible for …

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