Chao Tang

Overcoming Intrinsic Barriers in Myofibroblasts Permits Efficient Cardiac Reprogramming After Infarction

Jingdong Wu, Chunyan Yang, Donghui Wu, Shaoqi Zhu et autres

BACKGROUND: Direct reprogramming of cardiac fibroblasts (CFs) into induced cardiomyocytes (iCMs) holds promise as a therapeutic strategy for heart regeneration. After myocardial infarction (MI), resident quiescent CFs (QCFs) activate and differentiate into myofibroblasts (MFs) in the infarcted region that drive pathological cardiac …

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Reconstructing lineage-constrained gene-program dynamics with PhyloFM

Zihan Wang, Zhenyi Zhang, Xiaojing Yang, Chao Tang et autres

Abstract Cell-fate dynamics are defined not only by where cells end, but by when fate programs emerge, diverge, and reshape population structure. Much recent effort has been devoted to reconstructing these dynamics from temporally resolved single-cell RNA-seq and spatial transcriptomics. However, it …

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Microplastic biofilms enhance environmental stress, disinfectant, and antibiotic tolerance of Salmonella enterica serovar typhimurium in simulated fresh vegetable processing systems

Tianhao Zhou, Juncheng Chen, Zhuangli Kang, Jun Wang et autres

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Pancreatic islet oscillation rhythmicity arises from δ and α cell interactions

Huixia Ren, Yanjun Li, Beichen Xie, Zhenchao Fu et autres

Glucose-stimulated hormone secretion in pancreatic islets is closely linked to oscillations in cytoplasmic Ca 2+ , which arise from complex intra- and intercellular signaling. δ cells, intermingled with peripheral α cells, are important paracrine regulators, but their role in shaping Ca 2+ …

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The concurrent burden of Alzheimer’s pathology, cerebral amyloid angiopathy, and microinfarcts on cognitive decline

Mingyao You, Chao Tang, Lianfei Liu, Dengpeng Chen et autres

BACKGROUND: Alzheimer's disease (AD) is frequently complicated by vascular co-morbidities. However, the specific mechanistic pathways by which vascular lesions interact with genetic susceptibility to accelerate cognitive decline remain unclear. This study investigated whether cerebral amyloid angiopathy (CAA) and cortical microinfarcts mediate the …

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Gelatin modification enhances the osteoinductive capacity of demineralized bone matrix: In vitro evidence based on the mineralization of MC3T3-E1 cells

Chao Tang, Yun-Long Mao, Yong-feng Fan, Xiao-qiang Deng

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What questions currently beyond reach do you hope systems approaches will enable addressing in the next decade?

Ursula Klingmüller, Ricardo O. Ramirez Flores, Julio Sáez-Rodríguez, Paola Picotti et autres

Cross-conditions fault diagnosis of rolling bearing based on reliable domain adversarial network

Xunfan Ji, Jinliang Li, Chao Tang, Zhuoqi Shi et autres

To address inter-class confusion and ambiguous decision boundaries in traditional rolling-bearing fault diagnosis under varying operating conditions, we propose a reliable domain adversarial network (RDAN) that enables more discriminative and robust cross-condition fault identification. Specifically, the RDAN is designed with a multi-modal …

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Asymmetric impact of a 3D vortex ring on finite-width flexible plate at low Reynolds numbers

Jinming Yao, Yang Zhao, Huibo Zhang, Jianan Xu et autres

A numerical investigation of a vortex ring impinging asymmetrically on a finite-width flexible plate at Re =500, 1500, 2500 is conducted. Results reveal that 3D vortex dynamics significantly influence the plate’s energy harvesting efficiency. At Re =500, high viscosity inhibits the secondary …

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Effect of doping on hot-carrier thermal breakdown in perforated graphene metasurfaces

M. Ryzhii, V. Ryzhii, Chao Tang, T. Otsuji et autres

We examine the robustness of the S-shaped current-voltage characteristics associated with hot-carrier-induced electrical breakdown in perforated graphene metasurfaces (PGMs) as a function of doping. The perforation of the graphene layer forms interdigital arrays of graphene microribbons (GMRs) interconnected by graphene nanoribbon (GNR) …

Peptide hormone spexin restores beta cell function and improves glycaemic control in mice via regulation of the sodium–potassium pump

Yaojing Jiang, Di Wu, Yunzhi Ni, Ying Liu et autres

Clinical studies revealed that serum spexin level is positively associated with beta cell function. However, the role of spexin in beta cells remains unclear. We hypothesise that spexin treatment could influence beta cell function and modulate glucose homeostasis in vivo. We analysed …

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HGDiffuser: Efficient Task-Oriented Grasp Generation via Human-Guided Grasp Diffusion Models

Dehao Huang, Wenlong Dong, Chao Tang, Hong Zhang

Task-oriented grasping (TOG) is essential for robots to perform manipulation tasks, requiring grasps that are both stable and compliant with task-specific constraints. Humans naturally grasp objects in a task-oriented manner to facilitate subsequent manipulation tasks. By leveraging human grasp demonstrations, current methods …

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