Silvia Persichilli

Microplastics in Kidney Stones: A Preliminary Component of an Integrated One Health Investigation

Aniello Primiano, Lavinia Santucci, Michela Cicchinelli, Silvia Persichilli et autres

The widespread presence of microplastics (MPs) has emerged as a major One Health concern due to their increasing detection in human tissues and biological fluids. Within an integrated One Health research program, analytical workflows were developed to detect MPs across biological matrices. …

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Graft bile analysis for predicting post-transplant outcomes: A literature review and a protocol for a novel biomarker

Marco Maria Pascale, Jacopo Gervasoni, Giuseppe Bianco, Silvia Persichilli et autres

Liver transplantation (LT) remains the definitive treatment for end-stage liver disease, yet early detection of graft dysfunction and rejection is still challenging. Conventional blood-based markers provide systemic information but lack hepatic specificity. Bile, directly secreted by hepatocytes and cholangiocytes, represents an organ-specific …

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Impact of an autonomous delivery robot on sample turnaround time in a clinical laboratory: an early evaluation of first implementation

Jacopo Gervasoni, Davide Pedrazzini, Michela Cicchinelli, Silvia Persichilli et autres

OBJECTIVES: The aim of this study was to evaluate the impact of introducing an autonomous courier in a clinical laboratory, focusing on specimen turnaround time (TAT). We assessed whether high-frequency robotic transport from the central accessioning area to analytical sections could reduce …

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Analysis of Tacrolimus Concentration in Bile: A Patient-Specific Approach to the Early Detection of Acute Rejection After Liver Transplantation

Marco Maria Pascale, Jacopo Gervasoni, Giuseppe Bianco, Silvia Persichilli et autres

Introduction: Tacrolimus (TAC) stands out as one of the most widely utilized immu-nosuppressive drugs in the prevention of rejection following solid organ transplantation. In case of liver transplantation (LTx), the biochemical pathway for drug metabolism and excretion is an attribute of the …

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Development of a novel Ultra Performance Liquid Chromatography Tandem-Mass Spectrometry (UPLC-MS/MS) method to measure l-arginine metabolites in plasma

Lavinia Santucci, Sara Lomuscio, Aniello Primiano, Riccardo Calvani et autres

INTRODUCTION: Arginine metabolism is involved in the regulation of several biological processes. Many liquid chromatography tandem-mass spectrometry methods for the determination of arginine and its metabolites have been developed but they are time consuming and imply long pre-analytical procedures. The purpose of …

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Intestinal Permeability and Dysbiosis in Female Patients with Recurrent Cystitis: A Pilot Study

Cristina Graziani, Lucrezia Laterza, Claudia Talocco, Marco Pizzoferrato et autres

Recurrent cystitis (RC) is a common disease, especially in females. Anatomical, behavioral and genetic predisposing factors are associated with the ascending retrograde route, which often causes bladder infections. RC seems to be mainly caused by agents derived from the intestinal microbiota, and …

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Metabolic profiling of Costello syndrome: Insights from a single-center cohort

Chiara Leoni, Miriam Massese, Jacopo Gervasoni, Aniello Primiano et autres

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Folic Acid and Autism: A Systematic Review of the Current State of Knowledge

Bianka Hoxha, Malvina Hoxha, Elisa Domi, Jacopo Gervasoni et autres

Folic acid has been identified to be integral in rapid tissue growth and cell division during fetal development. Different studies indicate folic acid's importance in improving childhood behavioral outcomes and underline its role as a modifiable risk factor for autism spectrum disorders. …

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Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) detection as a rapid and convenient screening test for cystinuria

Aniello Primiano, Silvia Persichilli, Flavio Di Giacinto, Gabriele Ciasca et autres

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Erratum to “Prognostic Role of Serum Amino Acids in Head and Neck Cancer”

Gabriella Cadoni, Luca Giraldi, Carlo Chiarla, Jacopo Gervasoni et autres

[This corrects the article DOI: 10.1155/2020/2291759.].

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Investigating Different Forms of Hydrogen Sulfide in Cerebrospinal Fluid of Various Neurological Disorders

Viviana Greco, Cristina Neri, Damiana Pieragostino, Alida Spalloni et autres

Over the past 30 years a considerable amount of data has accumulated on the multifaceted role of hydrogen sulfide (H2S) in the central nervous system. Depending on its concentrations, H2S has opposite actions, ranging from neuromodulator to neurotoxic. Nowadays, accurate determination of …

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Fourier-Transform Infrared Spectroscopy of Skeletal Muscle Tissue: Expanding Biomarkers in Primary Mitochondrial Myopathies

Jacopo Gervasoni, Aniello Primiano, Federico Marini, Andrea Sabino et autres

Primary mitochondrial myopathies (PMM) are a group of mitochondrial disorders characterized by a predominant skeletal muscle involvement. The aim of this study was to evaluate whether the biochemical profile determined by Fourier-transform infrared (FTIR) spectroscopic technique would allow to distinguish among patients …

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