Intestinal Permeability and Dysbiosis in Female Patients with Recurrent Cystitis: A Pilot Study
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Le résumé fourni par la source
Recurrent cystitis (RC) is a common disease, especially in females. Anatomical, behavioral and genetic predisposing factors are associated with the ascending retrograde route, which often causes bladder infections. RC seems to be mainly caused by agents derived from the intestinal microbiota, and most frequently by Escherichia coli. Intestinal contiguity contributes to the etiopathogenesis of RC and an alteration in intestinal permeability could have a major role in RC. The aim of this pilot study is to assess gut microbiome dysbiosis and intestinal permeability in female patients with RC. Patients with RC (n = 16) were enrolled and compared with healthy female subjects (n = 15) and patients with chronic gastrointestinal (GI) disorders (n = 238). We calculated the Acute Cystitis Symptom Score/Urinary Tract Infection Symptom Assessment (ACSS/UTISA) and Gastrointestinal Symptom Rating Scale (GSRS) scores and evaluated intestinal permeability and the fecal microbiome in the first two cohorts. Patients with RC showed an increased prevalence of gastrointestinal symptoms compared with healthy controls. Of the patients with RC, 88% showed an increased intestinal permeability with reduced biodiversity of gut microbiota compared to healthy controls, and 68% of the RC patients had a final diagnosis of gastrointestinal disease. Similarly, GI patients reported a higher incidence of urinary symptoms with a diagnosis of RC in 20%. Gut barrier impairment seems to play a major role in the pathogenesis of RC. Further studies are necessary to elucidate the role of microbiota and intestinal permeability in urinary tract infections.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Intestinal Permeability and Dysbiosis in Female Patients with Recurrent Cystitis: A Pilot Study
- Date Crossref
- 20/06/2022
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Università Cattolica del Sacro Cuore pays non établi dans la noticeUniversité ou école supérieure
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Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la noticeÉtablissement de santé
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Humanitas University Department of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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IRCCS Humanitas Research Hospital pays non établi dans la noticeÉtablissement de santé
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Agostino Gemelli University Polyclinic pays non établi dans la noticeÉtablissement de santé
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Bambino Gesù Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Fondazione Policlinico Universitario “A. Gemelli” IRCCS CEMAD Digestive Diseases Center pays non établi dans la noticeÉtablissement de santé
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Dipartimento di Medicina e Chirurgia Traslazionale pays non établi dans la noticeInstitution
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Biochimica e Biologia Molecolare Clinica UOC Chimica pays non établi dans la noticeÉtablissement de santé
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Multimodal Laboratory Medicine Research Area pays non établi dans la noticeStructure de recherche
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Department of Prevention-Local Health Authority (AUSR-AV2) UOC ISP Prevention and Surveillance of Infectious and Chronic Diseases pays non établi dans la noticeOrganisme public
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Department of Diagnostic and Laboratory Medicine pays non établi dans la noticeStructure de recherche
Università Cattolica del Sacro Cuore, Istituti di Ricovero e Cura a Carattere Scientifico et Department of Biomedical Sciences — Humanitas University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.