Graft bile analysis for predicting post-transplant outcomes: A literature review and a protocol for a novel biomarker
Rattachement africain : it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Liver transplantation (LT) remains the definitive treatment for end-stage liver disease, yet early detection of graft dysfunction and rejection is still challenging. Conventional blood-based markers provide systemic information but lack hepatic specificity. Bile, directly secreted by hepatocytes and cholangiocytes, represents an organ-specific biofluid with diagnostic potential for assessing graft viability and early complications. This minireview examined the biochemical, immunological, and molecular features of bile as biomarkers in LT, focusing on pH, bicarbonate, glucose, lactate, bile acids, and proteomic/lipidomic profiles in relation to ischemia-reperfusion injury, early allograft dysfunction, and ischemic-type biliary lesions. The integration of bile-based parameters into ex situ perfusion and post-transplant monitoring, supported by omics technologies and predictive modeling, was also discussed. Building on these insights, we designed a single-center prospective study (ClinicalTrials.gov: NCT03882164) evaluating biliary tacrolimus (TACbile) as a predictor of acute rejection after LT. Paired daily TACbile and plasma tacrolimus levels are measured in recipients with Kehr T-tubes to define a blood-bile ratio of tacrolimus. The primary endpoint was the predictive accuracy of blood-bile ratio of tacrolimus for biopsy-proven rejection; secondary outcomes include associations with early allograft dysfunction. Bile-based biomarkers, particularly TACbile, may revolutionize graft monitoring and personalize immunological surveillance after LT.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Graft bile analysis for predicting post-transplant outcomes: A literature review and a protocol for a novel biomarker
- Date Crossref
- 27/01/2026
- Éditeur
- Baishideng Publishing Group Inc.
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Agostino Gemelli University Polyclinic pays non établi dans la noticeÉtablissement de santé
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Università Cattolica del Sacro Cuore pays non établi dans la noticeUniversité ou école supérieure
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS General Surgery and Organ Transplant Unit pays non établi dans la noticeÉtablissement de santé
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Biochimica e Biologia Molecolare Clinica Chimica pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine and Surgery pays non établi dans la noticeUniversité ou école supérieure
Agostino Gemelli University Polyclinic, Università Cattolica del Sacro Cuore et General Surgery and Organ Transplant Unit — Fondazione Policlinico Universitario Agostino Gemelli IRCCS, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.