Anne E. Manktelow

Brainstem neurochemical profiles after hospitalisation for COVID-19: a 7T MR spectroscopy study

Carina Graf, Betty Raman, Anne E. Manktelow, Doris A. Chatfield et autres

Background Somatic, cognitive and mental health issues have been identified in three-quarters of people 5 months after hospitalisation for severe acute SARS-CoV-2 (COVID-19) infection. The underlying neuroanatomical basis of these symptoms remains unclear, but recent studies suggest a role for altered brainstem …

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Drug Induced Lupus Secondary to Hydralazine Presenting as Diffuse Alveolar Hemorrhage and Glomerulonephritis

Anne E. Manktelow, Tao Yang, C. Dony

Abstract Drug-induced lupus (DIL) is a rare autoimmune disease that is seen following exposure to hydralazine. DIL commonly presents with nonspecific constitutional symptoms, polyarthralgias, rash, and serositis, with major organ involvement being uncommon. We present a case of suspected diffuse alveolar hemorrhage …

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Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations

Catarina Rua, Betty Raman, Christopher T. Rodgers, Virginia Newcombe et autres

Post-mortem studies have shown that patients dying from severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection frequently have pathological changes in their CNS, particularly in the brainstem. Many of these changes are proposed to result from para-infectious and/or post-infection immune responses. Clinical symptoms …

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Outcomes and Mechanisms Associated With Selective Thalamic Neuronal Loss in Chronic Traumatic Brain Injury

Rebecca Woodrow, Julia Grossac, Young T. Hong, Stefan Winzeck et autres

Importance: The chronic neuronal burden of traumatic brain injury (TBI) is not fully characterized by routine imaging, limiting understanding of the role of neuronal substrates in adverse outcomes. Objective: To determine whether tissues that appear healthy on routine imaging can be investigated …

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Systematic evaluation of fMRI data-processing pipelines for consistent functional connectomics

Andrea I. Luppi, Helena Marie Gellersen, Zhen-Qi Liu, Alexander R. D. Peattie et autres

Functional interactions between brain regions can be viewed as a network, enabling neuroscientists to investigate brain function through network science. Here, we systematically evaluate 768 data-processing pipelines for network reconstruction from resting-state functional MRI, evaluating the effect of brain parcellation, connectivity definition, …

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Methylphenidate Ameliorates Behavioural and Neurobiological Deficits in Executive Function for Patients with Chronic Traumatic Brain Injury

Alexander R. D. Peattie, Anne E. Manktelow, Barbara Jacquelyn Sahakian, David Krishna Menon et autres

(1) Background: Traumatic brain injury (TBI) often results in cognitive impairments, including in visuospatial planning and executive function. Methylphenidate (MPh) demonstrates potential improvements in several cognitive domains in patients with TBI. The Tower of London (TOL) is a visuospatial planning task used …

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Quantitative susceptibility mapping at 7 Tesla in COVID-19: mechanistic and outcome associations

Catarina Rua, Betty Raman, Christopher T. Rodgers, Virginia Newcombe et autres

Abstract Post mortem studies have shown that patients dying from severe SARS-CoV-2 infection frequently have pathological changes in their central nervous system, particularly in the brainstem. Many of these changes are proposed to result from para-infectious and/or post-infection immune responses. Clinical symptoms …

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Comparison of ComBat harmonization methods for longitudinal magnetic resonance imaging data in a travelling subject cohort

Sophie Richter, Stefan Winzeck, Marta Correia, Evgenios Kornaropoulos et autres

The trend in neuroimaging towards multi-site studies requires validated harmonization approaches to eradicate scanner differences which mask the biological effect of interest. Here, the harmonization algorithm ComBat and its modification for longitudinal data (LongComBat) were compared on a large travelling subject sample …

Converging on consistent functional connectomics

Andrea I. Luppi, Helena Marie Gellersen, Zhen-Qi Liu, Alexander R. D. Peattie et autres

Abstract Functional interactions between brain regions can be viewed as a network, empowering neuroscientists to leverage network science to investigate distributed brain function. However, obtaining a brain network from functional neuroimaging data involves multiple steps of data manipulation, which can drastically affect …

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In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape

Andrea I. Luppi, Justine Y. Hansen, R. Adapa, Robin Lester Carhart-Harris et autres

To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain's rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating the regional distribution …

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Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

Andrea I. Luppi, Jakub Vohryzek, Morten L. Kringelbach, Pedro A. M. Mediano et autres

A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals from pathological and pharmacologically-induced perturbations of consciousness into distributed patterns of structure-function dependence across scales: the harmonic modes …

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1790 Longitudinal coagulation profiles in patients presenting with acute severe traumatic brain injury (TBI): A prospective observational study

Liam Barrett, Anne E. Manktelow, William A. Thomas, Arthur Disegna et autres

Aims, Objectives and Background Patients who have sustained a traumatic brain injury (TBI) can have disturbances in coagulation that are distinct from other traumatic bleeding states.1 Coagulopathy is a risk factor for exacerbation of the primary injury, and these patients have less …

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