Brainstem neurochemical profiles after hospitalisation for COVID-19: a 7T MR spectroscopy study
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Le résumé fourni par la source
Background Somatic, cognitive and mental health issues have been identified in three-quarters of people 5 months after hospitalisation for severe acute SARS-CoV-2 (COVID-19) infection. The underlying neuroanatomical basis of these symptoms remains unclear, but recent studies suggest a role for altered brainstem physiology. We aimed to test the hypothesis that brainstem neurochemical profiles differ in patients who had been hospitalised for COVID-19 compared to matched controls using 7T magnetic resonance spectroscopy (MRS). Methods This prospective case–control study recruited 34 individuals who were hospitalised for COVID-19 and 15 healthy controls with no history of COVID-19 infection from two major UK hospitals before vaccines became available. The participants underwent 7T semi-adiabatic localization by adiabatic selective refocusing (sLASER) 1H-MRS at the ponto-medullary junction. Water-referenced metabolite concentrations were compared between the patients and controls and correlated with infection severity, as measured by maximum C-reactive protein (CRPmax) assay during inpatient admission. Linear mixed modelling was used with a 0.05 significance level. Results Spectral quality was high/acceptable in 44/49 participants according to the MRS Consensus criteria. The magnitude of inflammation during patient admission (i.e., CRPmax) correlated positively with myo-inositol concentration (β = 0.005, p = 0.035), as did patient-reported symptoms (β = −0.564, p = 0.023). However, metabolite concentrations were not significantly different between the patients and controls. Conclusion We show the feasibility of assessing brainstem neurochemical profiles using 7T 1H-MRS in a multi-centre study. Technical limitations at one site’s 7T MRI led to variable repetition times, which limited our statistical power and should be avoided in future studies. Our findings highlight the need for further investigation into the role of neuroinflammation in post-acute COVID-19.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Brainstem neurochemical profiles after hospitalisation for COVID-19: a 7T MR spectroscopy study
- Date Crossref
- 15/10/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Cambridge Department of Clinical Neurosciences pays non établi dans la noticeUniversité ou école supérieure
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Oxford University Hospitals NHS Trust pays non établi dans la noticeÉtablissement de santé
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John Radcliffe Hospital pays non établi dans la noticeÉtablissement de santé
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Wellcome Centre for Integrative Neuroimaging pays non établi dans la noticeStructure de recherche
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Perceptive Engineering (United Kingdom) pays non établi dans la noticeEntreprise
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Heidelberg University pays non établi dans la noticeUniversité ou école supérieure
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Central Institute of Mental Health pays non établi dans la noticeÉtablissement de santé
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University of Oxford Nuffield Department of Clinical Neurosciences pays non établi dans la noticeUniversité ou école supérieure
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MRC Cognition and Brain Sciences Unit pays non établi dans la noticeStructure de recherche
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Cambridge University Hospitals NHS Foundation Trust pays non établi dans la noticeOrganisme public
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Oxford University Hospitals NHS Foundation Trust Radcliffe Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Heidelberg Department of Addictive Behaviour and Addiction Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Clinical Neurosciences — University of Cambridge, Oxford University Hospitals NHS Trust et John Radcliffe Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.