Accès ouvert déclaré 2023 preprint

Quantitative susceptibility mapping at 7 Tesla in COVID-19: mechanistic and outcome associations

Catarina Rua, Betty Raman, Christopher T. Rodgers, Virginia Newcombe, Anne E. Manktelow, Doris A. Chatfield, Stephen J. Sawcer, Joanne G. Outtrim, Victoria C. Lupson, Emmanuel Andreas Stamatakis, Guy B. Williams, William T. Clarke, Lin Qiu, Martyn Ezra, Rory McDonald, Stuart Clare, Mark Philip Cassar, Stefan Neubauer, Karen D. Ersche, Edward Thomas Bullmore, David Krishna Menon, Kyle T.S. Pattinson, James Benedict Rowe

1Citations signalées, ce qui n’est pas une note de qualité

11Institutions déclarées

3Pays d’affiliation déclarés

Rattachement africain : gb, de, us. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Abstract Post mortem studies have shown that patients dying from severe SARS-CoV-2 infection frequently have pathological changes in their central nervous system, particularly in the brainstem. Many of these changes are proposed to result from para-infectious and/or post-infection immune responses. Clinical symptoms such as fatigue, breathlessness, and chest pain are frequently reported in post-hospitalized COVID-19 patients. We propose that these symptoms are in part due to damage to key neuromodulatory brainstem nuclei. While brainstem involvement has been demonstrated in the acute phase of the illness, the evidence of long-term brainstem change on magnetic resonance imaging (MRI) is inconclusive. We therefore used ultra-high field (7T) quantitative susceptibility mapping (QSM) to test the hypothesis that brainstem abnormalities persist in post-COVID patients and that these are associated with persistence of key symptoms. We used 7T QSM data from 30 patients, scanned 93 – 548 days after hospital admission for COVID-19 and compared them to 51 age-matched controls without prior history of COVID-19 infection. We correlated the patients’ QSM signals with disease severity (duration of hospital admission and COVID-19 severity scale), inflammatory response during the acute illness (C-reactive protein, D-Dimer and platelet levels), functional recovery (modified Rankin scale; mRS), depression (PHQ-9) and anxiety (GAD-7). In COVID-19 survivors the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery. Using non-invasive ultra-high field 7T MRI, we show evidence of brainstem pathophysiological changes associated with inflammatory processes in post-hospitalized COVID-19 survivors. This study contributes to understanding the mechanisms of long-term effects of COVID-19 and recovery.

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Quantitative susceptibility mapping at 7 Tesla in COVID-19: mechanistic and outcome associations
Date Crossref: 23/11/2023
Éditeur: openRxiv
Type: posted-content

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

University of Cambridge Department of Clinical Neurosciences pays non établi dans la notice
Université ou école supérieure
Invicro (United Kingdom) pays non établi dans la notice
Entreprise
University of Oxford Nuffield Department of Clinical Neurosciences pays non établi dans la notice
Université ou école supérieure
Oxford University Hospitals NHS Trust pays non établi dans la notice
Établissement de santé
Addenbrooke's Hospital pays non établi dans la notice
Établissement de santé
Wellcome Centre for Integrative Neuroimaging pays non établi dans la notice
Structure de recherche
Heidelberg University pays non établi dans la notice
Université ou école supérieure
Central Institute of Mental Health pays non établi dans la notice
Établissement de santé
Connecticut Department of Mental Health and Addiction Services pays non établi dans la notice
Organisme public
MRC Cognition and Brain Sciences Unit pays non établi dans la notice
Structure de recherche
Medical Research Council pays non établi dans la notice
Organisme public
Radcliffe Department of Medicine and Oxford University Hospitals NHS Foundation Trust Division of Cardiovascular Medicine pays non établi dans la notice
Université ou école supérieure

Department of Clinical Neurosciences — University of Cambridge, Invicro (United Kingdom) et Nuffield Department of Clinical Neurosciences — University of Oxford, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Long-Term Effects of COVID-19Infectious Encephalopathies and EncephalitisThermal Regulation in Medicine

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