Raúl Delgado‐Morales

Epigenome-wide profiling in the dorsal raphe nucleus highlights cell-type-specific changes in TNXB in Alzheimer’s disease

Renzo J. M. Riemens, Ehsan Pishva, Artemis Iatrou, Janou A. Y. Roubroeks et autres

Abstract Recent studies have demonstrated that the dorsal raphe nucleus (DRN) is among the first brain regions affected in Alzheimer’s disease. Hence, in this study we conducted the first comprehensive epigenetic analysis of the DRN in AD, targeting both bulk tissue and …

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A Synthetic mRNA Cell Reprogramming Method Using CYCLIN D1 Promotes DNA rEpair, Generating Improved Genetically Stable Human Induced Pluripotent Stem Cells

Ana Belén Alvarez-Palomo, Jordi Requena-Osete, Raúl Delgado‐Morales, Victoria Moreno‐Manzano et autres

A key challenge for clinical application of induced pluripotent stem cells (iPSC) to accurately model and treat human pathologies depends on developing a method to generate genetically stable cells to reduce long-term risks of cell transplant therapy. Here, we hypothesized that CYCLIN …

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The Arctic/Swedish APP mutation alters the impact of chronic stress on cognition in mice

Aurelio Cortese, Raúl Delgado‐Morales, Osborne F. X. Almeida, Carola Romberg

Chronic stress is a major risk factor for developing Alzheimer's disease (AD) and promotes the processing of amyloid precursor protein (APP) to β-amyloid (Aβ). However, the precise relationship of stress and disease-typical cognitive decline is presently not well understood. The aim of …

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Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling

Jordi Requena Osete, Ana Belén Alvarez-Palomo, M. Codina‐Pascual, Raúl Delgado‐Morales et autres

When considering the clinical applications of autologous cell replacement therapy of human induced pluripotent stem cells (iPSC)-derived cells, there is a clear need to better understand what the immune response will be before we embark on extensive clinical trials to treat or …

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Altered Regulation of KIAA0566, and Katanin Signaling Expression in the Locus Coeruleus With Neurofibrillary Tangle Pathology

Pol Andrés‐Benito, Raúl Delgado‐Morales, Isidró Ferrer

The locus coeruleus (LC), which contains the largest group of noradrenergic neurons in the central nervous system innervating the telencephalon, is an early and constantly vulnerable region to neurofibrillary tangle (NFT) pathology in aging and Alzheimer’s disease (AD). The present study using …

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Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice

Olga C. Jorge-Torres, Karolina Szczęsna, Laura M. Roa, Carmen Casal et autres

Rett syndrome (RTT) is the second leading cause of mental impairment in girls and is currently untreatable. RTT is caused, in more than 95% of cases, by loss-of-function mutations in the methyl CpG-binding protein 2 gene (MeCP2). We propose here a molecular …

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Directing neuronal cell fate in vitro: Achievements and challenges

Renzo J. M. Riemens, Daniël van den Hove, Manel Esteller, Raúl Delgado‐Morales

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Human-Induced Pluripotent Stem Cell-Derived Neurons to Model and Gain Insights into Alzheimer’s Disease Pathogenesis

Jessica E. Young, Raúl Delgado‐Morales

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Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders

Raúl Delgado‐Morales, Roberto Carlos Agís‐Balboa, Manel Esteller, María Berdasco

Ageing is the main risk factor for human neurological disorders. Among the diverse molecular pathways that govern ageing, epigenetics can guide age-associated decline in part by regulating gene expression and also through the modulation of genomic instability and high-order chromatin architecture. Epigenetic …

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Whole genome grey and white matter DNA methylation profiles in dorsolateral prefrontal cortex

José V. Sánchez‐Mut, Holger Heyn, Enrique Vidal, Raúl Delgado‐Morales et autres

The brain's neocortex is anatomically organized into grey and white matter, which are mainly composed by neuronal and glial cells, respectively. The neocortex can be further divided in different Brodmann areas according to their cytoarchitectural organization, which are associated with distinct cortical …

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Opening up the DNA methylome of dementia

Raúl Delgado‐Morales, Manel Esteller

Dementia is a complex clinical condition characterized by several cognitive impairments that interfere with patient independence in executing everyday tasks. Various neurodegenerative disorders have dementia in common among their clinical manifestations. In addition, these diseases, such as Alzheimer's disease, Parkinson's disease, dementia …

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Neuroepigenomics in Aging and Disease

Raúl Delgado‐Morales

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