Accès ouvert
2026
article
OpenAlex
Erik Moedt, Rémon Vos, Wenjun Ju, Stephan J. L. Bakker et autres
Urinary epidermal growth factor (uEGF) and clusterin (uCLU) are emerging biomarkers in chronic kidney disease (CKD), but rigorous analytical validation is required before clinical implementation. We evaluated intra-individual variability and long-term storage stability of uEGF and uCLU in CKD. In the prospective, …
nl, us, dk, it, es, de
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2025
article
OpenAlex
Erik Moedt, Rémon Vos, Wenjun Ju, Stephan J. L. Bakker et autres
Background: Qualified and validated biomarkers are essential to foster personalized medicine in nephrology. Epidermal growth factor (EGF) and clusterin (CLU) are emerging urinary biomarkers associated with kidney health and treatment response. We investigated intra-individual variation and long-term frozen-storage stability of EGF and …
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Accès ouvert
2024
article
OpenAlex
Sydney Elisabeth Gies, Sonja Hänzelmann, Dominik Kylies, Moritz Lassé et autres
In this study, we addressed challenges in integrating clinically obtained kidney biopsies into everyday clinical routines. Using porcine kidneys, we evaluated preservation media (RNAlater and CellCover) versus snap freezing for multi-omics processing. Our analyses highlighted RNAlater's suitability for single-nucleus RNA sequencing, proteome …
de, dk
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Accès ouvert
2023
article
OpenAlex
Moritz Lassé, Jamal El Saghir, Céline C. Berthier, Sean F. Eddy et autres
Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of their functional protein expression profile. Here, we define the organoid proteome and transcriptome trajectories over culture duration and upon exposure to TNFα, a …
de, us, dk
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2023
article
OpenAlex
Hans‐Joachim Paust, Ning Song, Donatella De Feo, Nariaki Asada et autres
GM-CSF in glomerulonephritis Despite glomerulonephritis being an immune-mediated disease, the contributions of individual immune cell types are not clear. To address this gap in knowledge, Paust et al . characterized pathological immune cells in samples from patients with glomerulonephritis and in samples …
de, ch
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Accès ouvert
2022
preprint
OpenAlex
Hans‐Joachim Paust, Ning Song, Donatella De Feo, Nariaki Asada et autres
ABSTRACT Glomerulonephritis is a group of immune-mediated diseases that cause inflammation within the glomerulus and adjacent compartments of the kidney and is a major cause of end-stage renal disease. T cells are among the main drivers of glomerulonephritis. However, the T cell …
de, ch
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Accès ouvert
2022
article
OpenAlex
Nicola Wanner, Geoffroy Andrieux, Pau Badia-i-Mompel, Carolin Edler et autres
Abstract Extrapulmonary manifestations of COVID-19 have gained attention due to their links to clinical outcomes and their potential long-term sequelae 1 . Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) displays tropism towards several organs, including the heart and kidney. Whether it also …
de, us
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