Nicola Wanner

From podocyte biology to glomerular medicine: the 15th International Podocyte Conference 2025

Badr Khbouz, Nicola Wanner, Laurel Damashek, Tobias B. Huber

The 15th International Podocyte Conference was held in Hamburg, Germany, from June 10 to 13, 2025, marking the inaugural meeting of the International Society of Glomerular Disease. The conference opened with a vibrant Pre-Meeting Day for Emerging Career Researchers, featuring early-career talks …

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WCN26-6846 CIRCULATING KIDNEY INJURY MARKERS AND INTERLEUKIN-10 IDENTIFY NON-CRITICALLY ILL COVID-19 PATIENTS AT RISK OF DEATH

Olivia Lenoir, Florence Morin, Léa Resmini, Mohamad Zaidan et autres

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Lysine-specific histone demethylase 1a regulates nephron development and long-term transcriptional programming

Nicola Wanner, Julia Keller, Nastassia Liaukouskaya, Geoffroy Andrieux et autres

Low nephron endowment constitutes a risk factor for hypertension and renal disease. Epigenetic regulation is crucial for nephron progenitor cell differentiation, affecting nephron number and renal function. The role of many epigenetic modulators, such as Lysine-specific histone demethylase 1a (LSD1 or KDM1A), …

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Gene count estimation with pytximport enables reproducible analysis of bulk RNA sequencing data in Python

Malte B. Kuehl, Milagros N. Wong, Nicola Wanner, Stefan Bonn et autres

Transcript quantification tools efficiently map bulk RNA sequencing reads to reference transcriptomes. However, their output consists of transcript count estimates that are subject to multiple biases and cannot be readily used with existing differential gene expression analysis tools in Python. Here we …

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Gene count estimation with pytximport enables reproducible analysis of bulk RNA sequencing data in Python

Malte B. Kuehl, Milagros N. Wong, Nicola Wanner, Stefan Bonn et autres

Transcript quantification tools efficiently map bulk RNA sequencing reads to reference transcriptomes. However, their output consists of transcript count estimates that are subject to multiple biases and cannot be readily used with existing differential gene expression analysis tools in Python. Here we …

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Levels of circulating kidney injury markers and IL-10 identify non-critically ill patients with COVID-19 at risk of death

Olivia Lenoir, Florence Morin, Anouk Walter-Petrich, Léa Resmini et autres

BACKGROUNDAfter identifying 2 immunomarkers of acute injury, KIM-1 and LCN2, in all kidney biopsies from 31 patients with COVID-19 pneumonia and de novo kidney dysfunction, we investigated whether circulating markers of kidney epithelial injury are common in patients with laboratory-confirmed COVID-19 who …

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Regulation of Glucose Handling in the Kidney

Nicola Wanner, Tobias Bruno Huber

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Pathology-oriented multiplexing enables integrative disease mapping

Malte B. Kuehl, Yusuke Okabayashi, Milagros N. Wong, Lukas Gernhold et autres

, the integration of biological layers (that is, cell structure, subcellular domains and signalling activity) remains challenging. This is due to limitations in the compositions of antibody panels and image resolution, which together restrict the scope of image analysis. Here we present …

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Kidney organoids from patient-derived induced pluripotent stem cells for the investigation of Fabry nephropathy

Anna Reinelt, Fabian Haas, Linda Blomberg, Christine E. Kurschat et autres

Advancing cardiac disease modeling in Fabry cardiomyopathy by utilizing patient-derived induced pluripotent stem cells, heart organoids, and engineered heart tissue

Anna Reinelt, Linda Blomberg, Christine E. Kurschat, Nicola Wanner et autres

ATP-Gated P2X7-Ion Channel on Kidney-Resident Natural Killer T Cells and Memory T Cells in Intrarenal Inflammation

Marten Junge, Nastassia Liaukouskaya, N. T. Schwarz, Carolina Pinto-Espinoza et autres

Key Points Parenchymal T cells in the kidney expressed much higher levels of P2X7 than vascular T cells. P2X7-blocking nanobodies uncover a large fraction of kidney-resident natural killer T and tissue-resident memory T cells. These cells were lost during cell preparation because …

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Gene count estimation with pytximport enables reproducible analysis of bulk RNA sequencing data in Python

Malte B. Kuehl, Milagros N. Wong, Nicola Wanner, Stefan Bonn et autres

SUMMARY: Transcript quantification tools efficiently map bulk RNA sequencing (RNA-seq) reads to reference transcriptomes. However, their output consists of transcript count estimates that are subject to multiple biases and cannot be readily used with existing differential gene expression analysis tools in Python.Here …

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