Aron B. Jaffe

Development of an investigational epigenetic silencer therapy to transcriptionally inactivate viral DNA in chronic hepatitis B

Yesseinia I. Angleró-Rodriguez, Qiang Xiong, Martino Alfredo Cappelluti, Sarah B. Voytek et autres

Approved chronic hepatitis B therapies rarely result in functional cure, as they fail to permanently silence all transcriptionally active hepatitis B virus (HBV) DNA. CRMA-1001 employs an optimized epigenetic silencer that represses viral transcription through targeted deposition of DNA methylation on episomal …

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A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels

Frédéric Tremblay, Qiang Xiong, Chih‐Wei Ko, Kenneth A. Kelly et autres

Epigenetic editing holds the promise of durable therapeutic effects by silencing disease-causing genes without changing the underlying DNA sequence. In this study, we designed an epigenetic editor to target human PCSK9 and thereby induce DNA methylation at this locus. A single administration …

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OS-090 Novel epigenetic editing technology targets hepatitis B virus in vivo to deeply and durably repress viral markers

Yesseinia I. Angleró-Rodriguez, Sahar Abubucker, John Xiong, Jhon Medina et autres

Alan Hall. 19 May 1952—3 May 2015

Laura M. Machesky, Aron B. Jaffe, Anne J. Ridley FRS

Alan Hall was born in a mining town in Yorkshire in 1952. He studied chemistry at Oxford and then, after starting his PhD in biochemistry in Oxford, he completed it at Harvard in the USA, where he made important discoveries about the …

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A map of signaling responses in the human airway epithelium

Katherine B. McCauley, Kalki Kukreja, Alfredo E. Tovar Walker, Aron B. Jaffe et autres

ch, us (code pays fourni par la source)

Durable Multiplex Epigenetic Editing for Generation of Allogeneic CAR T without Chromosomal Rearrangements

Jamie L. Schafer, Justin D. Trombley, Benjamin Hallisey, Kunza Ahmad et autres

CAR T therapies have provided significant breakthroughs for patients with CD19+ malignancies and multiple myeloma, but a major limitation is the need for individualized manufacturing of autologous T cells, increasing the cost and reducing the availability of these life-saving drugs. An allogeneic …

A map of signaling responses in the human airway epithelium

Katherine B. McCauley, Kalki Kukreja, Aron B. Jaffe, Allon Moshe Klein

Receptor-mediated signaling plays a central role in tissue regeneration, and it is dysregulated in disease. Here, we build a signaling-response map for a model regenerative human tissue: the airway epithelium. We analyzed the effect of 17 receptor-mediated signaling pathways on organotypic cultures …

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Photolysis of biomass burning organic aerosol, chemical transformations and photo-bleaching

Rachel E. O’Brien, Hongmin Yu, Natalie Warren, Marley Adamek et autres

Brown carbon (BrC) in aerosol particles and cloud droplets can contribute to climate warming by absorbing solar radiation in the visible region of the solar spectrum. Large uncertainties remain in our parameterization of this warming, in part due to a lack of …

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Molecular Insights into Dissolved Organic Matter in Natural Dew Water: Biogrime Films on Leaf Surfaces

Monica Dibley, Aron B. Jaffe, Rachel E. O’Brien

Dew water serves as a temporary reservoir of dissolved organic molecules that are released in the morning when the dew evaporates. Many locations allow for direct sunlight on the dew water in the morning, raising the possibility for photolysis-driven chemical reactions. The …

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UV/Vis and IRMPD Spectroscopic Analysis of the Absorption Properties of Methylglyoxal Brown Carbon

Lemai Vo, Emily Legaard, Corey Thrasher, Aron B. Jaffe et autres

Brown carbon (BrC) organic molecules absorb solar radiation in the visible range and thus can influence the optical properties of atmospheric aerosol particles and cloud droplets. The absorption properties for different types of BrC can change depending on the chemical environment of …

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Regeneration of airway epithelial cells to study rare cell states in cystic fibrosis

Pascal Barbry, Amélie Cavard, Marc Chanson, Aron B. Jaffe et autres

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A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

Lindsey W. Plasschaert, Rapolas Žilionis, Rayman Choo-Wing, Virginia Savova et autres

ch, cn, us, lt (code pays fourni par la source)