Kenneth A. Kelly

A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels

Frédéric Tremblay, Qiang Xiong, Chih‐Wei Ko, Kenneth A. Kelly et autres

Epigenetic editing holds the promise of durable therapeutic effects by silencing disease-causing genes without changing the underlying DNA sequence. In this study, we designed an epigenetic editor to target human PCSK9 and thereby induce DNA methylation at this locus. A single administration …

us, it (code pays fourni par la source)

Structure-based charge calculations for predicting isoelectric point, viscosity, clearance, and profiling antibody therapeutics

Nels Thorsteinson, John R. Gunn, Kenneth A. Kelly, Will Long et autres

The effect of hydrophobicity on antibody aggregation is well understood, and it has been shown that charge calculations can be useful for high-concentration viscosity and pharmacokinetic (PK) clearance predictions. In this work, structure-based charge descriptors are evaluated for their predictive performance on …

A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases

Alasdair C. Stamps, Moira A. Elmore, Maxine E. Hill, Kenneth A. Kelly et autres

A novel human homologue of Escherichia coli, yeast and plant 1-acylglycerol-3-phosphate acyltransferase has been isolated from U937 cell cDNA. Expression of the cloned sequence in 1-acylglycerol-3-phosphate acyltransferase-deficient E. coli resulted in increased incorporation of oleic acid into cellular phospholipids. Membranes made from …

gb (code pays fourni par la source)

Role of Cervicovaginal Antibody in the Pathogenesis of Recurrent Urinary Tract Infection in Women

Linda M. Kurdydyk, Kenneth A. Kelly, Godfrey K. M. Harding, Patricia Mirwaldt et autres

Introital colonization with Enterobacteriaceae is considered to be one of the principal predisposing factors to recurrent urinary tract infections (UTI) in adult females. One proposed mechanism allowing introital colonization in these patients is the absence of local cervicovaginal antibody. To test this …

ca (code pays fourni par la source)

A Radioimmunoassay for Isoniazid

Robert Schwenk, Kenneth A. Kelly, Kam S. Tse, Alec H. Sehon

A sensitive radioimmunoassay is described, for measuring isoniazid in therapeutic and subtherapeutic concentrations. This radioimmunoassay was used in an exploratory clinical study to measure, as a function of time, the concentration of this drug in plasma of patients receiving isoniazid therapy.

ca (code pays fourni par la source)

Substituted pyrazolo corticoids as topical antiinflammatory agents

John Hannah, Kenneth A. Kelly, Arthur A. Patchett, SANFORD L. STEELMAN et autres

The synthesis of a series of substituted pyrazolo corticoids is described. Of these 11beta,17alpha,21-trihydroxy-6,16alpha-dimethyl-4,6-pregnadieno[3,2-c]-2'-(4-pyridly)pyrazole (21) shows an excellent separation of systemic to local activity in the model animal test. Compound 21 exhibits high vasoconstriction activity in human volunteers and is clinically effective …

Blocking of the effect of Δ1tetrahydrocannabinol (ΔTHC) on spontaneous motor activity in the rat by immunization with a protein conjugate of Δ1THC

Meir Strahilevitz, Kenneth A. Kelly, Paulus T. Tsui, Alec H. Sehon

ca (code pays fourni par la source)

Will the OR Nurse be Needed in the Future?

Kenneth A. Kelly