Samuel Houle

Traumatic brain injury and post-injury sleep fragmentation differentially alter the microglial transcriptome

Morgan A. Taylor, Rebecca Boland, Samuel Houle, Zoe M. Tapp et autres

Introduction: Traumatic brain injury (TBI) is a global source of injury-related death and disability, and survivors often suffer functional and psychiatric consequences that persist for years. Neuroinflammation, mediated in part by microglia, perpetuates chronic dysfunction after TBI and leaves survivors vulnerable to …

us (code pays fourni par la source)

Sleep fragmentation after traumatic brain injury impairs behavior and conveys long-lasting impacts on neuroinflammation

Samuel Houle, Zoe M. Tapp, Shannon Dobres, Sakeef Ahsan et autres

Traumatic brain injury (TBI) causes a prolonged inflammatory response in the central nervous system (CNS) driven by microglia. Microglial reactivity is exacerbated by stress, which often provokes sleep disturbances. We have previously shown that sleep fragmentation (SF) stress after experimental TBI increases …

us (code pays fourni par la source)

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease

Kylene P. Daily, Asmaa N. Badr, Mostafa M. Eltobgy, Shady Z. K. Estfanous et autres

Abstract Alzheimer’s disease (AD) is the sixth leading cause of death in the USA. It is established that neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic decline of AD patients. Accumulating evidence suggests a critical role for microglia, innate immune …

us, Égypte, de (code pays fourni par la source)

Genetic diversity drives extreme responses to traumatic brain injury and post-traumatic epilepsy

Tyler Shannon, Christopher Cotter, Julie C. Fitzgerald, Samuel Houle et autres

Traumatic brain injury (TBI) is a complex and heterogeneous condition that can cause wide-spectral neurological sequelae such as behavioral deficits, sleep abnormalities, and post-traumatic epilepsy (PTE). However, understanding the interaction of TBI phenome is challenging because few animal models can recapitulate the …

us (code pays fourni par la source)

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer’s disease The Ohio State University College of Medicine

Kylene P. Daily, Asmaa N. Badr, Mostafa M. Eltobgy, Shady Z. K. Estfanous et autres

Abstract Alzheimer’s Disease (AD) is the 6th leading cause of death in the US. It is established that neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic decline of AD patients. Accumulating evidence suggests a critical role for microglia, innate immune …

ca, us, de (code pays fourni par la source)

Lateral Fluid Percussion Injury Causes Sex-Specific Deficits in Anterograde but Not Retrograde Memory

Julie C. Fitzgerald, Samuel Houle, Christopher Cotter, Zachary Zimomra et autres

Cognitive impairment is a common symptom after traumatic brain injury (TBI). Memory, in particular, is often disrupted during chronic post-injury recovery. To understand the sex-specific effects of brain injury on retrograde and anterograde memory, we examined paired associate learning (PAL), spatial learning …

us (code pays fourni par la source)

A Levee to the Flood: Pre-injury Neuroinflammation and Immune Stress Influence Traumatic Brain Injury Outcome

Samuel Houle, Olga N. Kokiko‐Cochran

Increasing evidence demonstrates that aging influences the brain's response to traumatic brain injury (TBI), setting the stage for neurodegenerative pathology like Alzheimer's disease (AD). This topic is often dominated by discussions of post-injury aging and inflammation, which can diminish the consideration of …

us (code pays fourni par la source)

Sleep fragmentation enhances inflammation and compromises stress-responsive neuronal activity following traumatic brain injury

Zoe M. Tapp, Julia E. Kumar, Sydney Cornelius, Alexa Oberster et autres

us (code pays fourni par la source)

Olfactory dysfunction in the 3xTg-AD model of Alzheimer’s disease

Darlene A. Mitrano, Samuel Houle, Patrick Pearce, Ricardo M. Quintanilla et autres

Alzheimer's disease (AD) is an incurable neurodegenerative disease in which the risk of development increases with age. People with AD are plagued with deficits in their cognition, memory, and basic social skills. Many of these deficits are believed to be caused by …

us (code pays fourni par la source)

Histochemical & Behavioral Analysis of the 3xTg‐AD Mouse Model of Alzheimer's Disease

Darlene A. Mitrano, Rachel Schendzielos, Emma E. Croushore, Benjamin C. Genovese et autres

Alzheimer's disease (AD) is an incurable neurodegenerative disease that affects about 11% of Americans age 65 and over and has very few FDA‐approved treatments. As the primary areas affected within the brain are the hippocampus and the cortex, the main reported symptoms …

us (code pays fourni par la source)

P.3.b.037 Neuroinflammation in schizophrenia: a PET study with [18F]-FEPPA

Miran Kenk, Thiviya Selvanathan, Naren Prahalada Rao, I. Suridjan et autres

Localization of the functional effects of clonidine by PET

Changlong Fu, Shitij Kapur, Samuel Houle, Gregory M. Brown