Simone Belmonti

Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy

Francesca Lombardi, Simone Belmonti, Alessia Sanfilippo, Alberto Borghetti et autres

BACKGROUND: Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favour of oxidants, that has been associated with an increased risk of morbidity and mortality in ART-treated people living with HIV (PLWH). We aimed to assess factors associated with …

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Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy

Francesca Lombardi, Simone Belmonti, Alessia Sanfilippo, Alberto Borghetti et autres

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Response to BNT162b2 mRNA COVID-19 vaccine of ART-experienced people living with HIV: a prospective analysis from a single-center study in Rome, Italy.

Francesca Lombardi, Simone Belmonti, Simona Di Giambendetto

Objectives: We aimed to assess the immunologic response to BNT162b2 mRNA COVID-19 vaccine in ART-experienced people living with HIV (PLWH). Methods: In this pilot prospective study, we enrolled 20 PLWH (all on effective ART, 80% with CD4 cells count >500) and 52 …

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Inflammation markers in virologically suppressed HIV-Infected patients after switching to dolutegravir plus lamivudine vs continuing triple therapy: 48-week results in real-life setting

Francesca Lombardi, Simone Belmonti, Davide Moschese, Massimiliano Fabbiani et autres

Objectives: To evaluate the impact of a treatment switch to dolutegravir plus lamivudine on the soluble inflammatory biomarkers of HIV-infected patients treated in a real-life setting.Materials and methods: This was a longitudinal study that enrolled virologically-suppressed patients on stable 3-drug ART who …

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External quality assessment of HIV-1 DNA quantification assays used in the clinical setting in Italy

Ilaria Vicenti, Filippo Dragoni, Alessia Giannini, Anna Casabianca et autres

Abstract Total cell-associated HIV-1 DNA is a surrogate marker of the HIV-1 reservoir, however, certified systems for its quantification are not available. The Italian HIV DNA Network was launched to validate HIV-1 DNA quantification methods in use at University and Hospital labs. …

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Quantification of Total HIV DNA as a Marker to Measure Viral Reservoir: Methods and Potential Implications for Clinical Practice

Simone Belmonti, Simona Di Giambenedetto, Francesca Lombardi

The focus of this review is to examine the importance of quantifying total HIV DNA to target the HIV reservoir and the clinical implications and challenges involved in its future application in clinical practice. Despite intrinsic limitations, the quantification of total HIV …

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Seroprevalence of SARS-CoV-2 Antibodies in HIV-Infected Patients in Rome, Italy during the COVID-19 Outbreak

Francesca Lombardi, Rosalba Ricci, Simone Belmonti, Massimiliano Fabbiani et autres

BACKGROUND: this study aimed to determine the proportion of people living with HIV (PLWH) with anti-SARS-CoV-2 IgG antibodies in a large sample from a single HIV referral center in Rome, Italy; the time-frame included both the first and the second wave of …

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Risk of Tumor Onset in HIV+ Patients on Two-Drug Regimens: A Cohort Study in an Italian Hospital

Alberto Borghetti, Stefania Bellino, Francesca Lombardi, Matteo Bernard Whalen et autres

Currently approved 2-drug therapies are as effective as 3-drug regimens but could potentially lead to increased cancer risk due to less efficient immune recovery. We conducted a longitudinal cohort study in a tertiary Italian hospital to investigate HIV+ patients starting a triple …

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No evidence of SARS-CoV-2 circulation in HIV-infected patients between December 2019 and February 2020 in Rome, Italy

Francesca Lombardi, Simone Belmonti, Rosalba Ricci, Alberto Borghetti et autres

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Transmitted drug resistance to NRTIs and risk of virological failure in naïve patients treated with integrase inhibitors

Alberto Borghetti, Arturo Ciccullo, Francesca Lombardi, Gianmaria Baldin et autres

OBJECTIVES: Nucleoside reverse transcriptase inhibitor (NRTI) transmitted drug resistance mutations (TDRMs) could increase the risk of virological failure (VF) of first-line integrase strand transfer inhibitor (InSTI)-based regimens. METHODS: Patients starting two NRTIs (lamivudine/emtricitabine plus abacavir/tenofovir) plus raltegravir or dolutegravir were selected from …

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Comparison of HIV-DNA decay in naive patients starting dolutegravir plus lamivudine or dolutegravir-based triple therapy.

Francesca Lombardi, Simone Belmonti, Alberto Borghetti, Arturo Ciccullo et autres

Not available.

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Evolution of cellular HIV DNA levels in virologically suppressed patients switching to dolutegravir/lamivudine versus maintaining a triple regimen: a prospective, longitudinal, matched, controlled study

Francesca Lombardi, Simone Belmonti, Alberto Borghetti, Massimiliano Fabbiani et autres

OBJECTIVES: To assess the impact of switching to dolutegravir plus lamivudine maintenance therapy on the HIV cellular reservoir size. PATIENTS AND METHODS: This was a prospective, longitudinal, matched, controlled study. We enrolled virologically suppressed patients on stable three-drug ART who switched at …

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