Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy
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Le résumé fourni par la source
BACKGROUND: Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favour of oxidants, that has been associated with an increased risk of morbidity and mortality in ART-treated people living with HIV (PLWH). We aimed to assess factors associated with OS in virologically suppressed PLWH on long-term modern ART. METHOD: In this cross-sectional study we evaluated OS by measuring both the levels of derivatives-reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP). We also calculated the BAP/d-ROMs ratio, (OS index, OSi); a cut-off value < 7.3 indicated OS. Factors associated with OS markers were explored by linear regression model. RESULTS: We enrolled 299 experienced PLWH with virological suppression (HIV-RNA < 50cps/mL). The mean of the d-ROMs levels was 409 UCARR (95%CI 394-422), whereas the mean of the BAP levels was 1.809 µmol/L (95%CI 1706-1851). The OSi mean value was 4.84, and 91.6% of the participants were below the cut-off value. By regression analysis, higher production of oxidants was associated with female sex (p < 0.001), current exposition to PIs (p = 0.030) and HCV co-infection (p = 0.006). Higher antioxidant capacity was correlated with higher HDL levels (p = 0.001). A lower OSi was associated with female sex (p = 0.003) and the current use of triple vs. dual regimen (p = 0.036). The OSi correlated negatively with cholesterol levels (p = 0.002) and positively with HDL (p < 0.001). CONCLUSIONS: Virologically suppressed PLWH on long-term ART showed a marked OS. Female sex, the exposure to PIs, and HCV co-infection were associated with higher oxidants, while higher HDL levels were linked to better antioxidant capacity. Interestingly, dual therapy, especially INSTI-based regimens, was associated with lower oxidative stress compared to triple therapy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy
- Date Crossref
- 30/12/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Università Cattolica del Sacro Cuore pays non établi dans la noticeUniversité ou école supérieure
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Agostino Gemelli University Polyclinic pays non établi dans la noticeÉtablissement de santé
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Azienda Ospedaliera Universitaria Senese pays non établi dans la noticeÉtablissement de santé
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Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la noticeÉtablissement de santé
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University of Pisa pays non établi dans la noticeUniversité ou école supérieure
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University of Siena Department of Medical Biotechnologies pays non établi dans la noticeUniversité ou école supérieure
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Dipartimento di Sicurezza e Bioetica pays non établi dans la noticeInstitution
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Fondazione Policlinico Universitario A. Gemelli IRCCS pays non établi dans la noticeÉtablissement de santé
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Infectious and Tropical Diseases Unit pays non établi dans la noticeInstitution
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Università di Pisa pays non établi dans la noticeInstitution
Università Cattolica del Sacro Cuore, Agostino Gemelli University Polyclinic et Azienda Ospedaliera Universitaria Senese, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.