Nicholas J. W. Rattray

Widespread detection of Polyethylene glycol reveals chronic human exposure through pharmaceutical drugs

Harsha Gouda, Patricia Kelly, Luke Whiley, Daniel Gómez‐Pérez et autres

Polyethylene glycol (PEG) is a synthetic polymer ubiquitous in pharmaceuticals, personal care products, food additives, and industrial manufacturing. Despite its widespread use and potential importance as an exposure chemical, the prevalence of PEG exposure and its excretion in human populations remain largely …

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Gluten free diet does not fully restore the faecal metabolome in paediatric coeliac disease

Nicholas J. W. Rattray, Patricia Kelly, Gillian Farrell, Richard Russell et autres

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Plate-based ISD-SPE enables dual proteome-secretome concentration-response profiling of TLR signalling in iPSC-derived macrophages

Chloe L. Tayler, Mengchun Li, Kerena Norris, Lee Booty et autres

Abstract Protein secretion represents a key functional output of cellular signalling, capturing dynamic responses to stimulation and pharmacological perturbation that shape immune behaviour. In macrophages, activation of Toll-like receptors (TLRs) drives tightly regulated secretion programmes that mediate inflammatory responses and provide a …

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REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect

Daisy Wilson, Animesh Acharjee, Niharika Duggal, Jose R. Hombrebueno et autres

BACKGROUND: Ageing is associated with reduced resilience to physiological stressors such as infection and surgery. This reduced resilience is believed to be underpinned by the hallmarks of ageing, the key biological mechanisms driving the aged phenotype. Geroprotectors are drugs that are proposed …

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Translational toolkit for reproducible, cross-study profiling of human ageing hallmarks in human blood and tissue

Kristina Tomkova, Jonathan W. Lewis, Thomas Nicholson, Animesh Acharjee et autres

Abstract Background Ageing is a complex, multi-dimensional process, underpinned by interacting biological hallmarks that collectively contribute to functional decline and increased susceptibility to disease. While considerable progress has been made in delineating individual ageing pathways, translation into human studies has been hindered …

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Large-scale antibody reactome profiling identifies herpesvirus-autoantigen associations underlying chronic diseases

Sanghun Lee, Nicole Prince, Qingwen Jia Xiaohan Chen, Xueying Chen et autres

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REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect. Rationale and protocol for a trial of biological effect

Daisy Wilson, Animesh Acharjee, N. Duggal, Jose R Hombrebueno et autres

Abstract Background Ageing is associated with reduced resilience to physiological stressors such as infection and surgery. This reduced resilience is believed to be underpinned by the hallmarks of ageing, the key biological mechanisms driving the aged phenotype. Geroprotectors are drugs that are …

gb (code pays fourni par la source)

Pan-repository analysis reveals a drug-activating function of microbial bile acid conjugation

Vincent Charron-Lamoureux, Patricia E. Kelly, Simone Zuffa, Abubaker Patan et autres

Abstract Microbially modified bile acids shape host physiology by regulating nutrient absorption, glucose homeostasis, circadian rhythms and thermoregulation. Here we identify a previously unrecognized drug-activating function of microbial bile acid conjugation. By systematically mining human LC–MS/MS datasets across public repositories and linking …

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dia-PASEF Enables Rapid Profiling of the Human Secretome for Deeper Insights into Cellular Dynamics and Inflammatory Mechanisms

Chloe L. Tayler, Serena Bateman, Charlie Haslam, Leonie Müller et autres

Abstract Protein secretion is a fundamental mechanism for cellular coordination and signalling, with its dysregulation leading to widespread physiological dysfunction and disease. Immunoassay formats that utilise secondary antibody readouts are the current gold standard for measuring secreted proteins, offering high specificity and …

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The use of frailty screening measures for predicting long-term survival outcomes in head and neck cancer : a systematic review

Shina Ardani, Fa'izan Shah, Rhona Hurley, Nicholas J. W. Rattray et autres

Background: The distinction between frailty and ageing is becoming increasingly recognised, however, the clinical implication of this in head and neck cancers has not been fully explored. In this review we evaluate the prognostic value of frailty, assessed through established screening tools, …

Learning molecular fingerprints of foods to decode dietary intake

Pieter C. Dorrestein, Harsha Gouda, Julius Agongo, Patricia E. Kelly et autres

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Colorectal cancer molecular profiling: Opportunities for early detection

Alexandra Sala, Lisa van den Driest, Nicholas J. W. Rattray, Caroline H. Johnson et autres

Colorectal cancer (CRC) is one of the most common and deadliest cancers worldwide, and incidence rates are rising. However, early detection and intervention can improve the survival rates and quality of life of affected patients. Current screening tests used to streamline patients …

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