Qingwen Jia Xiaohan Chen

Large-scale antibody reactome profiling identifies herpesvirus-autoantigen associations underlying chronic diseases

Sanghun Lee, Nicole Prince, Qingwen Jia Xiaohan Chen, Xueying Chen et autres

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Differences in microRNA levels across metabo-endotypes reveal novel insights into asthma heterogeneity

Rinku Sharma, R Kelly, Kevin Mendez, Qingwen Jia Xiaohan Chen et autres

RATIONALE: We previously validated five clinically distinct asthma metabo-endotypes (mechanistically derived asthma subgroups). We hypothesize that metabo-endotype membership may be partially driven by differences in serum microRNA profiles and their influence on metabolite levels. OBJECTIVES: To determine whether serum miRNA levels can …

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Multi-omics Analysis of Human Blood Cells Reveals Unique Features of Age-associated Type2 CD8 Memory T cells

Hiroyuki Matsui, Marlene Cervantes, Mir M. Khalid, Alan Tomusiak et autres

Aging impacts immune function, but the mechanisms driving age-related changes in immune cell subsets remain unclear. To explore age-dependent changes in immune cell populations, we analyzed human peripheral blood mononuclear cells (PBMCs) from a cohort of healthy donors aged 20-82 years using …

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Prevalence of diabetes and determinants: evidence from a minority region in People’s Republic of China

Qingwen Jia Xiaohan Chen, Yi Yao, Ningshao Xia, Chi Li et autres

Qingyun Chen,1 Yanhua Yi,2 Ning Xia,1 Chunling Li,3 Zuojie Luo,1 Gaoming Huang,3 Ying Chen,1 Shumin Li,4 Luhua Lai,1 Mingdeng Wang,5 Jing Tan,6 Jie Zhang,1 Hanlei Shen,1 Bixun Li,7 Feiqun Su,8 Hua Wei,5 Xia Dai,1 Fengji Lu,9 Shuilian Li8 1Department of Endocrinology, First …

Is Type 2 Diabetes One of Such Aging Phenomena That Lack an Irreversible Structural Change?

Qingwen Jia Xiaohan Chen

All biological functions should have a structural basis.Any functional change should be due to an alteration in the related structure.If a functional change is irreversible, it should be due to the irreversibility of the structural alteration.For instance, cancer is irreversible because cancer …

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