Accès ouvert
2025
article
OpenAlex
Andrea Cortegiani, Gennaro De Pascale, Giulia De Angelis, Marco Falcone et autres
Critically ill patients in Intensive Care Units are at high risk of developing invasive candidiasis (IC). Delay in diagnosis and suboptimal management contribute to high mortality rates, highlighting the need for an appropriate and patient-tailored approach. The Italian Society of Anaesthesia, Analgesia, …
it, gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Dimitri Budinger, Sharmin Alhaque, Ramón González‐Méndez, Chris Dadswell et autres
Manganese (Mn) is an essential trace metal required for normal biological function, yet it also poses neurotoxic risks when dysregulated. Maintaining proper intracellular and extracellular Mn levels is critical, as Mn imbalance has been implicated in a spectrum of human diseases-including inherited …
gb, ae, Égypte, de, au
(code pays fourni par la source)
2024
preprint
OpenAlex
Dimitri Budinger, Sharmin Alhaque, Ramón González‐Méndez, Chris Dadswell et autres
ABSTRACT Manganese (Mn) is an essential trace metal that is necessary for life. Its duality as both a crucial micronutrient and potential neurotoxicant necessitates tight control of intracellular and extracellular Mn levels. Dysregulation of Mn is implicated in a broad range of …
gb, ae, Égypte, de, au
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Arianna Ferrini, Dora Steel, Katy Barwick, Manju A. Kurian
Adenylyl cyclase 5 (ADCY5)-related phenotypes comprise an expanding disease continuum, but much remains to be understood about the underlying pathogenic mechanisms of the disease. ADCY5-related disease comprises a spectrum of hyperkinetic disorders involving chorea, myoclonus, and/or dystonia, often with paroxysmal exacerbations. Hypotonia, …
gb
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Audrey Soo, Arianna Ferrini, Manju A. Kurian
Increasingly effective targeted precision medicine is either already available or in development for a number of genetic childhood movement disorders. Patient-centred, personalized approaches include the repurposing of existing treatments for specific conditions and the development of novel therapies that target the underlying …
gb
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Amy McTague, Giada Rossignoli, Arianna Ferrini, Serena Barral et autres
Therapeutic advances for neurological disorders are challenging due to limited accessibility of the human central nervous system and incomplete understanding of disease mechanisms. Many neurological diseases lack precision treatments, leading to significant disease burden and poor outcome for affected patients. Induced pluripotent …
gb
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Dora Steel, Michael Zech, Chen Zhao, Katy Barwick et autres
OBJECTIVES: The majority of people with suspected genetic dystonia remain undiagnosed after maximal investigation, implying that a number of causative genes have not yet been recognized. We aimed to investigate this paucity of diagnoses. METHODS: We undertook weighted burden analysis of whole-exome …
gb, de, au, it, sk, in, nl, us, ie, pl, at, cz
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Limor Zwi‐Dantsis, Charles W. Winter, Ulrike Kauscher, Arianna Ferrini et autres
Extracellular vesicles (EVs) represent a promising cell-free alternative for treatment of cardiovascular diseases. Nevertheless, the lack of standardised and reproducible isolation methods capable of recovering pure, intact EVs presents a significant obstacle. Additionally, there is significant interest in investigating the interactions of …
ch, gb, us
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Limor Zwi‐Dantsis, Brian Wang, Camille Marijon, Simone Zonetti et autres
Abstract The ability to manipulate cellular organization within soft materials has important potential in biomedicine and regenerative medicine; however, it often requires complex fabrication procedures. Here, a simple, cost‐effective, and one‐step approach that enables the control of cell orientation within 3D collagen …
gb
(code pays fourni par la source)
Accès ouvert
2019
dataset
OpenAlex
Limor Zwi‐Dantsis, Baojun Wang, Camille Marijon, Simone Zonetti et autres
Research data supporting the publication: Zwi-Dantsis et al., 2020, Advanced Materials, DOI: 10.1002/adma.201904598.
gb
(code pays fourni par la source)
Accès ouvert
2019
dataset
OpenAlex
Limor Zwi‐Dantsis, Baojun Wang, Camille Marijon, Simone Zonetti et autres
Research data supporting the publication: Zwi-Dantsis et al., 2020, Advanced Materials, DOI: 10.1002/adma.201904598.
gb
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Arianna Ferrini, Molly M. Stevens, Susanne Sattler, Nadia Rosenthal
Myocardial Infarction (MI) is the most common cardiovascular disease. An average-sized MI causes the loss of up to 1 billion cardiomyocytes and the adult heart lacks the capacity to replace them. Although post-MI treatment has dramatically improved survival rates over the last …
gb, us
(code pays fourni par la source)