Xiaoyu Yang

A spinoreticular pathway mediates nocifensive responses to noxious mechanical stimuli

Yuan Liu, Qing Li, Jun-Kai Lin, Yifei Han et autres

Spinal projection neurons (SPNs) relay somatosensory information to the brain, yet how molecularly defined SPN subsets transmit noxious mechanical signals to drive nocifensive behaviors remains unclear. Here, we identify Sncg -expressing SPNs ( Sncg + SPNs) that convey noxious mechanical signals through …

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Microglial pruning of extinction-ensemble synapses preserves fear memory

Yongling Wang, Yue Cao, Taohui Liu, Tian-Tian Shi et autres

SUMMARY Fear extinction suppresses learned fear without erasing the original memory, yet how competing fear and extinction ensembles are selectively updated remains unknown. Here, we show that microglia preserve fear memory by selectively editing extinction-ensemble synapses during retrieval. In medial prefrontal cortex, …

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Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation

Xin Yi, Yuan-Bo Zhang, Tong-Zhou Yu, Xiaoyu Yang et autres

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Dual-Pathway Synergistic Catalysis Enabled by Spin-Dependent Redox Electrochemistry Engineering in Nickel-based (Oxy)hydroxides for Enhanced Water Oxidation

Xiaomei Wang, Yufei Zhang, Yanpei Luo, Xiaoyu Yang et autres

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A dual-enzyme-like nanozyme adjuvant alleviates tumor hypoxia to enhance photothermally ferroptosis-immune synergistic tumor therapy

Peng Chang, Dehong Chen, Xiaoyu Yang, Ying Liu et autres

Immune adjuvants play a critical role in cancer vaccines and emerging therapies. However, conventional adjuvants may fail to effectively stimulate cytotoxic T lymphocyte (CTL)-mediated immune responses. Nanozyme-based adjuvants, particularly manganese-based nanozymes, demonstrate significant potential by integrating enzymatic activity with immune modulation. Herein, …

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Adolescents’ Hormone Level and Circadian Rhythm: A Literature Review.

Xiaoyu Yang

Adolescence is characterized by complicated hormonal and neural interactions, particularly within circadian rhythms. The roles of melatonin, growth hormone, and cortisol in shaping adolescent circadian rhythms are clarified, as well as their implications for physical and mental health. Circadian rhythm disorders (CRDs), …

Research on the Evaluation of Financial Performance of Supor Based on EVA Perspective

Jing Chen, Xiaoyu Yang

After the introduction of EVA into China, SASAC found that EVA is very effective in the evaluation of enterprise financial performance, so it began to implement the EVA financial performance evaluation method to domestic enterprises. Among the enterprises adopting EVA for financial …

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FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1‐mediated DeSUMOylation

Wei Sun, Xiaoyu Yang, Lijuan Chen, Lu Guo et autres

Alveolar epithelial cell (AEC) senescence-induced changes of lung mesenchymal cells are key to starting the progress of pulmonary fibrosis. Follistatin-like 1 (FSTL1) plays a central regulatory role in the complex process of senescence and pulmonary fibrosis by enhancing transforming growth factor-β1 (TGF-β1) …

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METTL16 Mediated LncRNA TIALD m6A Modification contributes to hepatocellular carcinoma metastasis via inducing AURKA lysosomal degradation

Bixing Zhao, Yingchao Wang, Yue Zhong, Xiaoyuan Zheng et autres

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Long non-coding RNA COX7C-5 promotes hepatocellular carcinoma progression via miR-581/ZEB2 axis

Yantin Lin, Fei Wang, Yue Zhong, Niang Mei Cheng et autres

Long non-coding RNAs (lncRNA) play crucial roles in hepatocellular carcinoma (HCC) progression. However, the functional roles of lncRNAs in HCC still remain largely unknown. Our study aimed to investigate the biological function and potential molecular mechanism of lnc-COX7C-5 in HCC. Here, we …

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Oxygen–Glucose Deprivation Promoted Fibroblast Senescence and Collagen Expression via IL11

Tongtong Song, Yiwen Gu, Wenting Hui, Xiaoyu Yang et autres

Cell senescence is one of the most important forms of injury induced by cardiovascular and other ischemic diseases. Fibroblasts are important participants in tissue repair after ischemic injury and the main source of IL11 secretion. However, the roles of oxygen-glucose deprivation (OGD) …

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Scalp Nerve Block, Local Anesthetic Infiltration, and Postoperative Pain After Craniotomy: A Systematic Review and Network Meta-analysis of Randomized Trials

Mengqiang Luo, Xu Zhao, Meng Deng, Yue Hu et autres

The most efficacious methods for controlling postoperative pain in craniotomy remain unknown. A systematic review and network meta-analysis were performed to compare the efficacies of different strategies of scalp nerve block (SNB), scalp infiltration (SI), and control in patients undergoing craniotomy. MEDLINE, …

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