Yiwen Gu

Elevated cyclic hydrostatic pressure enhances the transfection activity of lipoplexes by activating clathrin-mediated endocytosis

Xiaowei Ding, Yizhuo Wu, Yiwen Gu, Cheng Hanxiao et autres

Despite significant advancements in liposome-mediated transfection technology over the past decades, achieving optimal transfection efficiency with lipoplex remains challenging in certain primary cells, such as vascular smooth muscle cells, endothelial cells, and suspension cells. Here, we present an innovative approach to significantly …

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Action observation therapy impact on mirror neurons combined with acupuncture for upper limb motor impairment rehabilitation in stroke patients

Dilinuer Maimaitiaili, Jue Shi, Chunlei Shan, Li Jin et autres

Abstract: OBJECTIVE: Upper limb (UL) dysfunction rehabilitation in stroke patients is complicated in the clinic. Action observation therapy’s (AOT) impact on mirror neurons (MNs) has been observed and made applications in related brain disease treatment. Acupuncture mentioned in the present study mainly …

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Levocarnitine regulates the growth of angiotensin II-induced myocardial fibrosis cells via TIMP-1

Shu Jin, Jue Shi, Yiwen Gu, Lei Deng et autres

Abstract This study aimed to explore the effects of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) on levocarnitine (LC)-mediated regulation of angiotensin II (AngII)-induced myocardial fibrosis (MF) and its underlying mechanisms. H9C2 cells were treated with AngII for 24 h to induce fibrosis. The …

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Oxygen–Glucose Deprivation Promoted Fibroblast Senescence and Collagen Expression via IL11

Tongtong Song, Yiwen Gu, Wenting Hui, Xiaoyu Yang et autres

Cell senescence is one of the most important forms of injury induced by cardiovascular and other ischemic diseases. Fibroblasts are important participants in tissue repair after ischemic injury and the main source of IL11 secretion. However, the roles of oxygen-glucose deprivation (OGD) …

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Bismuth Vanadium Oxide Can Promote Growth and Activity in Arabidopsis thaliana

Cong Gao, Shuai Lu, Yongzhou Wang, Hao Xu et autres

The excellent properties of nanomaterials have been confirmed in many fields, but their effects on plants are still unclear. In this study, different concentrations of bismuth vanadate (BV) were added to the growth medium to analyze the growth of seedlings, including taproots, …

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Sodium butyrate protects against focal cerebral ischemic injury through the regulation of the nuclear receptor Nur77

Lihui Men, Tongtong Song, Xi Wang, Wenting Hui et autres

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Bismuth Vanadium Oxide can Promote the Growth and Activity of Roots in Arabidopsis thaliana

Cong Gao, Shuai Lü, Yongzhou Wang, Hao Xu et autres

The excellent properties of nanomaterials have been confirmed in many fields, but the effects on plants are still unclear. In this study, we have found that bismuth vanadium promoted the growth of taproots and the development of lateral roots, increased the roots …

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Matrix metalloproteinase 3 regulates angiotensin II‑induced myocardial fibrosis cell viability, migration and apoptosis

Shu Jin, Yiwen Gu, Jin Li

Angiotensin II (AngII) is a central signaling molecule of the renin‑angiotensin system that serves a vital role in myocardial fibrosis (MF). The present study aimed to investigate the effects of matrix metalloproteinase (MMP)3 on MF progression. To induce cellular fibrosis, H9C2 rat …

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Proteomic Analysis Reveals the Effect of Trichostatin A and Bone Marrow-Derived Dendritic Cells on the Fatty Acid Metabolism of NIH3T3 Cells under Oxygen–Glucose Deprivation Conditions

Xuan Wang, Tongtong Song, Yunpeng Sun, Lihui Men et autres

Fibroblasts mediate acute wound healing and long-term tissue remodeling with scarring after tissue injury. Following myocardial infarction (MI), necrotized cardiomyocytes become replaced by secreted extracellular matrix proteins produced by fibroblasts. Dendritic cells (DCs) can migrate from the bone marrow to the infarct …

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Regulatory Effect of Angelica sinensis Polysaccharide on Bcl-2/Bax/Caspase-3 Signal Pathway in Spleen of Rats with Radiation Injury

Tianli Chen, Tongtong Song, Xu Sun, Yiwen Gu et autres

To investigate the protective effect of Angelica sinensis polysaccharide (ASP) on spleen injury and its influence of Bcl-2/Bax/Caspase-3 signal pathway in radiation rats, 60 Sprague Dawley (SD) rats were divided into 5 groups randomly: the normal group, the model group, low-, middle- …

Quantitative Proteomics and Immunohistochemistry Reveal Insights into Cellular and Molecular Processes in the Infarct Border Zone One Month after Myocardial Infarction

Libang Yang, Zachery R. Gregorich, Wenxuan Cai, Patrick Zhang et autres

Postinfarction remodeling and expansion of the peri-infarct border zone (BZ) directly correlate with mortality following myocardial infarction (MI); however, the cellular and molecular mechanisms underlying remodeling processes in the BZ remain unclear. Herein, we utilized a label-free quantitative proteomics approach in combination …

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In reply to “Is intrathecal lidocaine administration risk‐free in rats with neuropathic pain?”

Jie Tian, Yiwen Gu, Diansan Su, Xiangrui Wang

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