Christina Schier

Combating Black Fungus: Using Allicin as a Potent Antifungal Agent against Mucorales

Christina Schier, Martin C. H. Gruhlke, Georg Reucher, Alan John Slusarenko et autres

Invasive fungal (IF) diseases are a leading global cause of mortality, particularly among immunocompromised individuals. The SARS-CoV-2 pandemic further exacerbated this scenario, intensifying comorbid IF infections such as mucormycoses of the nasopharynx. In the work reported here, it is shown that zygomycetes, …

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Seeing the smell of garlic: Detection of gas phase volatiles from crushed garlic (Allium sativum), onion (Allium cepa), ramsons (Allium ursinum) and human garlic breath using SESI-Orbitrap MS

Hendrik G. Mengers, Christina Schier, Martín Zimmermann, Martin C. H. Gruhlke et autres

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Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig

Christina Schier, Jana Foerster, Monika Heupel, Philipp Dörner et autres

Fungal infections of the lung are an increasing problem worldwide and the search for novel therapeutic agents is a current challenge due to emerging resistance to current antimycotics. The volatile defence substance allicin is formed naturally by freshly injured garlic plants and …

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Optimization and Validation of a Microcolony Multiplexed Opsonophagocytic Killing Assay for 15 Pneumococcal Serotypes

Katrina M. Nolan, Marie Bonhomme, Christina Schier, Tina Green et autres

Background: To streamline and improve throughput, the agar-based multiplexed opsonophagocytic killing assay (MOPA) was optimized and validated on a microcolony platform for use in the Phase III clinical trial program for V114, an MSD 15-valent pneumococcal conjugate vaccine candidate. Results & methodology: …

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Genetic and molecular characterization of multicomponent resistance of Pseudomonas against allicin

Jan Borlinghaus, Anthony Bolger, Christina Schier, Alexander Vogel et autres

The common foodstuff garlic produces the potent antibiotic defense substance allicin after tissue damage. Allicin is a redox toxin that oxidizes glutathione and cellular proteins and makes garlic a highly hostile environment for non-adapted microbes. Genomic clones from a highly allicin-resistant Pseudomonas …

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Plant-microbe co-evolution: allicin resistance in a Pseudomonas fluorescens strain ( Pf AR-1) isolated from garlic

Jan Borlinghaus, Anthony Bolger, Christina Schier, Alexander Vogel et autres

The antibiotic defense substance allicin (diallylthiosulfinate) is produced by garlic ( Allium sativum L.) after tissue damage, giving garlic its characteristic odor. Allicin is a redox-toxin that oxidizes thiols in glutathione and cellular proteins. A highly allicin-resistant Pseudomonas fluorescens strain ( Pf …

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Plant-microbe co-evolution : allicin resistance in a Pseudomonas fluorescens strain (PfAR-1) isolated from garlic

Jan Borlinghaus, Anthony Bolger, Christina Schier, Alexander Vogel et autres

Opiate Addiction Therapies and HIV-1 Tat: Interactive Effects on Glial [Ca2+]i, Oxyradical and Neuroinflammatory Chemokine Production and Correlative Neurotoxicity

Sylvia Fitting, Shiping Zou, Nazira El‐Hage, Masami Suzuki et autres

Few preclinical studies have compared the relative therapeutic efficacy of medications used to treat opiate addiction in relation to neuroAIDS. Here we compare the ability of methadone and buprenorphine, and the prototypic opiate morphine, to potentiate the neurotoxic and proinflammatory ([Ca²⁺]i, ROS, …

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