Dympna Gallagher

The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens

Michael Rosenbaum, Kelly C. Allison, Maren R. Laughlin, Stephanie S. Kelley et autres

Abstract The Physiology Of the WEight Reduced State (POWERS) study is a multi-center clinical trial designed to understand the physiological basis for observed variability in weight regain following intentional weight loss among US adults. The primary dependent variable is weight regain over …

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The Physiology Of the WEight Reduced State (POWERS) study: design and rationale for assessment of food intake, physical activity and other behavioral constructs

Laurel Mayer, Michael R. Lowe, Kelly C. Allison, Maxine Ashby-Thompson et autres

Abstract The Physiology Of the WEight Reduced State (POWERS) study is a multi-center NIH-funded clinical trial designed to determine the physiological basis for variability in weight loss maintenance among adults with obesity following participation in a behavioral weight loss program. Two hundred …

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The Physiology Of the WEight Reduced State (POWERS) study: overview and study design

Steven H. Belle, Dympna Gallagher, Susan B. Roberts, Maren R. Laughlin et autres

Obesity is a multifactorial disease caused by physiological and environmental factors. Adults who have obesity are at increased risk for several additional chronic and infectious diseases, resulting in reduced life expectancy, compared to those with lower body mass indices. Weight loss (WL) …

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Understanding Impact of Anti‐Obesity Medications on Skeletal Muscle Mass Change Is Confounded by Measurement Methods

Arden McMath, Dympna Gallagher

Anti-obesity medications promote greater degrees of weight loss than lifestyle interventions alone. There is an important need to understand whether loss of skeletal muscle during pharmacologically induced weight loss is clinically significant due to its essential role in health and disease. Most …

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The Physiology Of the WEight Reduced State (POWERS) study: assessing energy balance

Michael Rosenbaum, Kelly C. Allison, Maren R. Laughlin, Kathryn Whyte et autres

Abstract Background/objectives We provide the rationale for and description of energy balance measures (i.e., energy intake and energy expenditure) in The P hysiology O f the WE ight R educed S tate (POWERS) study which aims to understand the contribution of the …

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Introduction to the special issue describing the Physiology Of the WEight Reduced State (POWERS) Study

Steven H. Belle, Susan B. Roberts, Dympna Gallagher, Maren R. Laughlin

In 2019, the Office of Nutrition Research at the National Institute of Diabetes and Digestive and Kidney Diseases convened a workshop to address an important issue in the treatment of people with obesity or overweight, i.e., weight regain following weight loss. Specifically, …

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LIFE-Moms: effects of multicomponent lifestyle randomized control trial on physical activity during pregnancy in women with overweight and obesity

Hannah E. Cabre, Kimberly L. Drews, Jeremy Pomeroy, Sarah Kozey Keadle et autres

BACKGROUND: This report details the effect of LIFE-Mom's multicomponent lifestyle interventions on physical activity (PA) and inactivity time across pregnancy (2nd and 3rd trimesters) and their effect on gestational weight gain (GWG) and maternal/neonatal outcomes, a pre-specified secondary analysis. METHODS: were randomized …

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The Physiology of the WEight-Reduced State (POWERS) study: environmental, psychological, and social determinants of health

Sai Krupa Das, Giada Benasi, Susan Z. Yanovski, Stephanie Kelley et autres

Intentional weight loss is often followed by unintentional weight regain. The causes of weight regain are uncertain but may include a myriad of responses that result in increased hunger and decreased energy expenditure. An individual's psychological state and social and physical environments …

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Metabolic Health and Heterogenous Outcomes of Prenatal Interventions

Emily W. Flanagan, Kimberly L. Drews, W. Todd Cade, Paul W. Franks et autres

Importance: Prenatal intensive behavioral therapy (IBT) interventions that promote adequate gestational weight gain (GWG) have had variable and mostly modest effects on clinically relevant maternal and infant outcomes. It is unknown whether different maternal obesity metabolic phenotypes underlie the heterogeneity in response. …

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Trimester of maternal SARS-CoV-2 infection differentially predicts newborn size in the COVID-19 Mother Baby Outcomes (COMBO) cohort

Margaret H. Kyle, Presley Nichols, Lerzan Coskun, William P. Fifer et autres

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Dietary misreporting: a comparative study of recalls vs energy expenditure and energy intake by doubly-labeled water in older adults with overweight or obesity

Leinys S. Santos‐Báez, Michele Novaes Ravelli, Diana A. Díaz‐Rizzolo, Collin Popp et autres

BACKGROUND: Self-report methods are widely used to assess energy intake but are prone to measurement errors. We aimed to identify under-reported, over-reported, and plausible self-reported energy intake by dietary recalls (rEI) using a standard method (Method 1) that calculates the rEI ratio …

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BMI profiling for monogenic obesity testing

Vidhu Thaker, Dympna Gallagher

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