Leonardo Camilo de Oliveira

THE STRUCTURES OF MATURE AND IMMATURE ST. LOUIS ENCEPHALITIS VIRUS REVEAL CONSERVED HISTIDINE RESIDUES AFFECTING VIRUS FITNESS

Laís D. Coimbra, Samuel Leite Guimarães, Luiza Leme, Alice Nagai et autres

Orthoflaviviruses undergo significant structural changes through maturation and infection, yet the molecular mechanisms remain incompletely understood. Using St. Louis encephalitis virus (SLEV) as a model, a reemerging mosquito-borne orthoflavivirus endemic in the Americas, we elucidated the structures of immature and mature SLEV …

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Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2, Herpes Simplex Virus Type 1, Vaccinia Virus, and Human Adenovirus Type II in Water using Ultraviolet Light-Emitting Diodes at 265 nm and 275 nm

Túlio Cesar Floripes, Cesar Rossas Mota, Leonardo Camilo de Oliveira

ABSTRACT Waterborne viruses, such as adenovirus, herpesvirus, severe acute respiratory syndrome coronavirus 2, and vaccinia virus, pose a health risk due to their persistence and structural variability. Ultraviolet C light-emitting diodes have emerged as a promising alternative to conventional mercury lamps, due …

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Antiviral and Immunomodulatory Effects of 7-Deaza-2-methyladenosine (7DMA) in a Susceptible Mouse Model of Usutu Virus Infection

Rebeca de Paiva Fróes Rocha, Marina Alves Fontoura, Fabrício Fredo Naciuk, Leonardo Camilo de Oliveira et autres

Usutu virus (USUV) is an emerging arbovirus recently associated with outbreaks in Western Europe. Although USUV is typically associated with asymptomatic or nonspecific febrile disease, the occurrence of severe neuroinvasive forms of disease has raised concern. There is currently no antiviral treatment …

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Non-invasively measuring small airway RNA load & inflammation in acute COVID-19 at resource-limited primary care

Sterghios Athanasios Moschos, Pedro Almeida, Leonardo Camilo de Oliveira, Daniel Querioz et autres

SARS-CoV-2 RNA was not detectable in end-tidal oral exhaled breath condensates (EBC) depleted of saliva-containing large droplets (LD)1. We evaluated if sampling by singing impacts saliva contamination, virus detection sensitivity, & cytokine profiling in EBC. Symptomatic cases (0-5 days from onset, n=30; …

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Lysergol exerts potent antiviral activity against the emerging Oropouche virus in vitro

Laís D. Coimbra, Jacqueline Farinha Shimizu, Alice Nagai, Alexandre Borin et autres

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Activity of Sesquiterpene Lactones and Umbelliferone From Campovassouria cruciata on SARS‐CoV‐2 Replication and on the Release of Pro‐Inflammatory Cytokines in Lung Cells

Márcio Dias Rabelo, Kátia Michelle Freitas, Leonardo Camilo de Oliveira, Alessandra Caroline Montes Frade et autres

ABSTRACT The investigation of natural products is a valid strategy to identify compounds active against coronaviruses. We herein report the screening of Baccharis and Campovassouria plant species against the murine betacoronavirus murine hepatitis virus‐3 (MHV‐3), assays that can be carried out in …

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Antiviral effect of Bromelain combined with acetylcysteine against SARS-CoV-2 Omicron variant

Erik Vinícius de Sousa Reis, Linziane Lopes Ferreira, Felipe Alves Clarindo, Geovane Marques-Ferreira et autres

The recent pandemic represented one of the biggest challenges of modern civilization. SARS-CoV-2 remains an imminent public health threat and currently, there is no effective and greatly affordable treatment for severe COVID-19. Although standard management with dexamethasone, and physical management including physiotherapy, …

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One Health Surveillance for SARS-CoV-2 in Non-Human Primates and Small Mammals in Minas Gerais, Brazil

Pedro Augusto Almeida-Souza, Thamires Gabriele Macedo Silva, Gabriele Barbosa Penha, Thaynara de Jesus Teixeira et autres

Although the SARS-CoV-2 pandemic primarily affected the human population, the virus has also been detected in various animal species worldwide, raising concerns about its potential to establish new animal reservoirs. This study aimed to investigate the presence of SARS-CoV-2 in non-human primates …

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Ouratein D, a Biflavanone From Ouratea spectabilis, Alleviates Betacoronavirus Infection by Mitigating Inflammation, Lung Damage and Viral Replication

Adelson Héric Alves Monteiro, Kátia Michelle Freitas, Ana Clara M. Montuori‐Andrade, Antônio Felipe Silva Carvalho et autres

ABSTRACT Severe coronavirus outbreaks, including SARS, MERS, and COVID‐19, have underscored the urgent need for effective antiviral therapies. This study evaluated the antiviral activity of biflavanones isolated from Ouratea spectabilis—specifically ouratein (Our‐) A, B, C, and D—against murine hepatitis virus (MHV‐3) and …

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Intranasal liposomal remdesivir induces SARS-CoV-2 clearance in K18-hACE2 mice and ensures survival

Sabrina Mendes, Lays Cordeiro Guimarães, Leonardo Camilo de Oliveira, Pedro Augusto Carvalho Costa et autres

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Antiviral Activity of Electrospun Polyamide Ultrathin Fibers Against SARS-CoV-2 Variant

Moisés V. Santana, Gustavo Fernandes de Sousa, Marcus Vinicius Gonçalves da Silva, Lays Cordeiro Guimarães et autres

The development of new strategies to produce nanomaterials that can be used as personal protective equipment with antiviral activity and low toxicity is crucial. Electrospun ultrathin fibers have attracted considerable attention due to their potential for biomedical applications, including antiviral activity. Herein, …

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The deep roots and emplacement of Santonian intrusions in the Pre-Salt reservoirs of the Mero Field, Santos Basin, Brazil

Gabriel Medeiros Marins, Nicholas Machado Lima, Leonardo Camilo de Oliveira, Adriana O. Gangá et autres

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