Samih Mohamed‐Ahmed

Allogeneic stem cell strategies in bone regeneration: A systematic review and meta-analysis

Paul Åsmund Vågen, Lado Lako Loro, Samih Mohamed‐Ahmed, Stein Atle Lie et autres

Autologous mesenchymal stem cells (MSC) are widely regarded as the gold standard for stem cell-based bone regenerative applications due to their strong osteogenic potential. This systematic review with meta-analysis aims to evaluate existing evidence on the use of allogeneic MSC as an …

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AgNPs–Cellulose Nanofiber/Polyacrylamide Hydrogels as an Antibacterial Platform for Soft Tissue

Ioana Maria Marinescu, Andrada Serafim, Elena Olăreț, Bogdan Ştefan Vasile et autres

Modern wound care is challenged by the emergence of antibiotic-resistant bacterial strains, causing the need for advanced dressing materials that provide infection control while promoting healing. Although polyacrylamide (PAAm) hydrogels are widely investigated due to their biocompatibility, their lack of intrinsic antibacterial …

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Intrathecal mesenchymal stem cell therapy in progressive multiple sclerosis: cross-compartment immune profiling in the SMART-MS randomized trial

Dimitrios Kleftogiannis, Sonia Gavasso, Live Egeland Eidem, Jonas Bull Haugsøen et autres

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Mechanical Manipulation of Fat: From Lipoaspirate to Stromal Vascular Fraction Concentrate

Kjersti Ausen, Anne Dorthea Bjerkenes Rø, Gunnhild V. Leirvik, Sara B. S. Årbogen et autres

BACKGROUND: The adipose stromal vascular fraction (SVF) is a mesh of connective tissue, capillaries, stem cells and supportive cells which may have regenerative properties. Attention is shifting from enzymatic isolation and expansion of the stem cell population alone, to the benefit of …

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Triazine‐Trione Thermosets with High Processability for Scaffold Applications in Bone Tissue Engineering

Åshild Johansen, Shuntaro Yamada, Daniel J. Hutchinson, Mohammed A. Yassin et autres

Despite advances in scaffold development, many current biomaterials suffer from limited processability or poor biological performance. To address this, we previously introduced two novel triazine-trione (TATO)-based thermosets, T-ene and T-yne, as candidates for tissue engineering applications. In the present study, we aim …

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MDS BIOLOGY AND PATHOGENESIS - MDS MOUSE MODELS (GEMMS, PDX)

Ana Maria Torres S. De Mesquita, Constance De Montlaur, Mihaela Lucia Popa, Samih Mohamed‐Ahmed et autres

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Bone Augmentation of Atrophic Alveolar Ridges Using a Synthetic Bone Substitute With Mesenchymal Stem Cells: A Randomized, Controlled Clinical Trial

Mariano Sanz, Cecilie Gjerde, Bjørn Tore Gjertsen, Alberto Ortiz‐Vigón et autres

ABSTRACT Objectives To assess the efficacy and safety of a cell‐based therapy for 3D bone augmentation of severe alveolar bone defects prior to dental implant placement. Materials and Methods A Phase 2 randomized controlled clinical trial evaluated the safety and efficacy of …

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Osteogenic Potential of 3D-Printed Porous Poly(lactide-co-trimethylene carbonate) Scaffolds Coated with Mg-Doped Hydroxyapatite

Mehmet Serhat Aydin, Carmen-Valentina Nicolae, Elisabetta Campodoni, Samih Mohamed‐Ahmed et autres

High Resolution Image Download MS PowerPoint Slide Extrusion-based 3D printing of thermoplastic polymers presents significant potential for bone tissue engineering. However, a key limitation is the frequent absence of filament porosity and the inherent osteoconductive properties. This study addresses these challenges by …

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Injectable Dendritic Hydrogels Curable by High-Energy Visible Light for Cell Delivery in Bone Regeneration

Noemí Molina, Francesco Torelli, Samih Mohamed‐Ahmed, Daniel J. Hutchinson et autres

Hydrogels loaded with bone marrow mesenchymal stem cells (BMSCs) have emerged as a promising alternative to grafting for bone regeneration in critical-sized fractures and defects. Here, we present a platform for an injectable bone scaffold hydrogel that cures in situ via high-energy …

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Bioprinting of mesenchymal stem cells in low concentration gelatin methacryloyl/alginate blends without ionic crosslinking of alginate

Masoumeh Jahani Kadousaraei, Shuntaro Yamada, Mehmet Serhat Aydin, Ahmad Rashad et autres

Bioprinting allows for the fabrication of tissue-like constructs by precise architecture and positioning of the bioactive hydrogels with living cells. This study was performed to determine the effect of very low concentrations of alginate (0.1, 0.3, and 0.5% w/v) on bioprinting of …

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Effects of Magnesium-Doped Hydroxyapatite Nanoparticles on Bioink Formulation for Bone Tissue Engineering

Margherita Montanari, Jannika T. Korkeamäki, Elisabetta Campodoni, Samih Mohamed‐Ahmed et autres

High Resolution Image Download MS PowerPoint Slide Bioprinting of nanohydroxyapatite (nHA)-based bioinks has attracted considerable interest in bone tissue engineering. However, the role and relevance of the physicochemical properties of nHA incorporated in a bioink, particularly in terms of its printability and …

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Impact of Porosity and Stiffness of 3D Printed Polycaprolactone Scaffolds on Osteogenic Differentiation of Human Mesenchymal Stromal Cells and Activation of Dendritic Cells

Mehmet Serhat Aydin, Nora Marek, Samih Mohamed‐Ahmed, Bodil Kristina Lund et autres

Despite the potential of extrusion-based printing of thermoplastic polymers in bone tissue engineering, the inherent nonporous stiff nature of the printed filaments may elicit immune responses that influence bone regeneration. In this study, bone scaffolds made of polycaprolactone (PCL) filaments with different …

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