Mehmet Serhat Aydin

Nanostructured multicomponent bioinks with nanodiamond and magnesium-doped nanohydroxyapatite for enhanced bone tissue engineering

Carmen-Valentina Nicolae, Masoumeh Jahani Kadousaraei, Shuntaro Yamada, Mehmet Serhat Aydin et autres

• Dual-nanoparticle system enhances bioink performance for bone regeneration. • Nanodiamonds enhance printability and cell adhesion; Mg-hydroxyapatite supports osteogenesis. • Computational modeling with realistic geometry improves extrusion behavior prediction. • Novel bioink addresses the trade-off between printability and biological performance. Designing bioinks …

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Design, fabrication, and modeling of a polypyrrole-coated TPMS-based piezoresistive sensor

Isil Demirkan, Ece Naz Erulker, Mehmet Serhat Aydin, Ayca Aydurmus et autres

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Enhancing Cellular Interactions Through Bioactivation and Local Nanomechanical Reinforcement in Nanodiamond-Loaded 3D-Printed Gellan Gum Scaffolds

Carmen-Valentina Nicolae, Masoumeh Jahani Kadousaraei, Elena Olăreț, Andrada Serafim et autres

The integration of nanomaterials within hydrogel scaffolds offers significant promise in bone tissue engineering by improving mechanical performance and modulating cellular responses through mechanotransductive and biochemical signaling. Previous studies have demonstrated that nanodiamonds (NDs) incorporated in electrospun microfibrillar meshes enhance cellular adhesion, …

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Osteogenic Potential of 3D-Printed Porous Poly(lactide-co-trimethylene carbonate) Scaffolds Coated with Mg-Doped Hydroxyapatite

Mehmet Serhat Aydin, Carmen-Valentina Nicolae, Elisabetta Campodoni, Samih Mohamed‐Ahmed et autres

High Resolution Image Download MS PowerPoint Slide Extrusion-based 3D printing of thermoplastic polymers presents significant potential for bone tissue engineering. However, a key limitation is the frequent absence of filament porosity and the inherent osteoconductive properties. This study addresses these challenges by …

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Bioprinting of mesenchymal stem cells in low concentration gelatin methacryloyl/alginate blends without ionic crosslinking of alginate

Masoumeh Jahani Kadousaraei, Shuntaro Yamada, Mehmet Serhat Aydin, Ahmad Rashad et autres

Bioprinting allows for the fabrication of tissue-like constructs by precise architecture and positioning of the bioactive hydrogels with living cells. This study was performed to determine the effect of very low concentrations of alginate (0.1, 0.3, and 0.5% w/v) on bioprinting of …

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3D-Printed Functionally Graded PCL-HA Scaffolds with Multi-Scale Porosity

Hatice Kübra Bilgili, Mehmet Serhat Aydin, Mervenaz Sahin, Sevilay Burcu Sahin et autres

Functionally graded scaffolds (FGSs) designed for bone tissue regeneration exhibit three-dimensional (3D) constructs with spatially varying pores, mirroring the natural bone structure, aiming to offer temporary support and a conducive environment for cells during tissue regeneration in defect sites. While existing research …

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Impact of Porosity and Stiffness of 3D Printed Polycaprolactone Scaffolds on Osteogenic Differentiation of Human Mesenchymal Stromal Cells and Activation of Dendritic Cells

Mehmet Serhat Aydin, Nora Marek, Samih Mohamed‐Ahmed, Bodil Kristina Lund et autres

Despite the potential of extrusion-based printing of thermoplastic polymers in bone tissue engineering, the inherent nonporous stiff nature of the printed filaments may elicit immune responses that influence bone regeneration. In this study, bone scaffolds made of polycaprolactone (PCL) filaments with different …

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PHASE SEPARATION AND PARTICULATE LEACHING INTEGRATED 3D PRINTING OF POROUS SCAFFOLDS FOR BONE TISSUE ENGINEERING APPLICATIONS

Mehmet Serhat Aydin

Conventional 3D printing by itself is incapable of creating pores on a micro scale within deposited filaments throughout 3D scaffolds. These pores and hence larger surface areas are needed for cells to be adhered, proliferated, and differentiated. The aim of this work …

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