2026
conference-abstract
OpenAlex
Claudio Vernieri, Giovanni Fucà, Francesca Ligorio, Laura Tronci et autres
Abstract Introduction: Cyclic fasting and fasting-mimicking diets (FMDs) showed broad antitumor activity in mice with breast cancer (BC), with promising results in patients (pts) enrolled in conpleted or ongoing clinical trials (NCT03340935; NCT03454282; NCT04248998; NCT05763992). However, with the exception of glucose and …
it
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Giulia Bastianello, Gururaj Rao Kidiyoor, Conor Lowndes, Qingsen Li et autres
Confined cell migration hampers genome integrity and activates the ATR and ATM mechano-transduction pathways. We investigated whether the mechanical stress generated by metastatic interstitial migration contributes to the enhanced chromosomal instability observed in metastatic tumor cells. We employed live cell imaging, micro-fluidic …
it, sg
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Mattia Pavani, Elena Chiroli, Camilla Cancrini, Fridolin Groß et autres
Drugs targeting microtubules rely on the mitotic checkpoint to arrest cell proliferation. The prolonged mitotic arrest induced by such drugs is followed by a G1 arrest. Here, we follow for several weeks the fate of G1-arrested human cells after treatment with nocodazole. …
it, fr, hu
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Mattia Pavani, Paolo Bonaiuti, Elena Chiroli, Fridolin Groß et autres
it, sg, hu
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Mattia Pavani, Paolo Bonaiuti, Elena Chiroli, Fridolin Groß et autres
ABSTRACT Microtubules, polymers of alpha- and beta-tubulin, are essential cellular components. When microtubule polymerization is hindered, cells are delayed in mitosis, but eventually they manage to proliferate with massive chromosome missegregation. Several studies have analyzed the first cell division upon microtubules impairing …
it, sg, hu
(code pays fourni par la source)