Fridolin Groß

A human-specific microRNA controls the timing of excitatory synaptogenesis

Michael Soutschek, Alessandra Lo Bianco, Simon Galkin, Tatjana Wüst et autres

Neural circuit development in the human cortex is considerably prolonged in comparison to non-human primates, a trait that contributes to the remarkable cognitive capacity of modern humans. Here, we explore the regulatory role of non-coding RNAs, which dramatically expanded during brain evolution, …

ch, fr, dk (code pays fourni par la source)

A human-specific microRNA controls the timing of excitatory synaptogenesis

Michael Soutschek, Alessandra Lo Bianco, Simon Galkin, Tatjana Wüst et autres

Abstract Neural circuit development in the human cortex is considerably prolonged in comparison to non-human primates, a trait that contributes to the remarkable cognitive capacity of modern humans. Here, we explore the regulatory role of non-coding RNAs, which dramatically expanded during brain …

Response to comment on: Is “pre-sepsis” the new sepsis? A narrative review

Rémy Gerard, Antoine Dewitte, Fridolin Groß, Thomas Pradeu et autres

fr (code pays fourni par la source)

Is “pre-sepsis” the new sepsis? A narrative review

Rémy Gerard, Antoine Dewitte, Fridolin Groß, Thomas Pradeu et autres

Sepsis is a life-threatening condition caused by a dysregulated immune response to infection, leading to organ dysfunction and high mortality. Despite advances in treatment, sepsis remains difficult to manage. Historically, the concept of sepsis evolved from ancient observations of infection-related decay to …

fr, us (code pays fourni par la source)

lncreased risk of slippage upon disengagement of the mitotic checkpoint

Alma Beatrix Stier, Paolo Bonaiuti, János Juhász, Fridolin Groß et autres

Drugs that impair microtubule dynamics alter microtubule-kinetochore attachment and invoke the mitotic checkpoint which arrests cells in mitosis. The arrest can last for hours, but it is leaky: cells adapt (i.e., slip out of it) and exit from mitosis. Here, we investigate …

hu, it, fr (code pays fourni par la source)

miR-708-5p is elevated in bipolar patients and can induce mood disorder-associated behavior in mice

Carlotta Gilardi, Helena Caria Martins, Brunno Rocha Levone, Alessandra Lo Bianco et autres

Mood disorders (MDs) are caused by an interplay of genetic and environmental (GxE) risk factors. However, molecular pathways engaged by GxE risk factors are poorly understood. Using small-RNA sequencing in peripheral blood mononuclear cells (PBMCs), we show that the bipolar disorder (BD)-associated …

ch, fr, us, de, be (code pays fourni par la source)

Evolutionary adaptation to hyperstable microtubules selectively targets tubulins and is empowered by the spindle assembly checkpoint

Francesca Macaluso, Tasia Bos, Elena Chiroli, Paolo Bonaiuti et autres

Microtubules are polymers required for chromosome segregation. Their drug-induced hyperstabilization impairs chromosome segregation and is an established anti-cancer therapy. How cells respond to microtubule hyperstabilization, however, is incompletely understood. To study this, we evolved budding yeast cells expressing a microtubule-hyperstabilizing tubulin mutant …

it, us, fr, hu (code pays fourni par la source)

Early life stress-induced miR-708-5p regulates mood disorder-associated behavioural phenotypes in mice and is a potential diagnostic biomarker for bipolar disorder

Carlotta Gilardi, Helena Caria Martins, Alessandra Lo Bianco, Silvia Bicker et autres

Abstract Mood-disorders (MDs) are caused by a complex interplay of genetic and environmental (GxE) risk factors. However, the molecular pathways engaged by GxE risk factors to trigger specific MD-associated endophenotypes are still poorly understood. Here, by using unbiased small RNA sequencing in …

us, ch, it, de, be (code pays fourni par la source)

The Explanatory Role of Machine Learning in Molecular Biology

Fridolin Groß

fr (code pays fourni par la source)

Reuniting philosophy and science to advance cancer research

Thomas Pradeu, Bertrand Daignan‐Fornier, Andrew J. Ewald, Pierre‐Luc Germain et autres

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, …

fr, us, ch, gb, it, no, ca, hu, nl, dk, es (code pays fourni par la source)

Triap1 upregulation promotes escape from mitotic-slippage-induced G1 arrest

Mattia Pavani, Elena Chiroli, Camilla Cancrini, Fridolin Groß et autres

Drugs targeting microtubules rely on the mitotic checkpoint to arrest cell proliferation. The prolonged mitotic arrest induced by such drugs is followed by a G1 arrest. Here, we follow for several weeks the fate of G1-arrested human cells after treatment with nocodazole. …

it, fr, hu (code pays fourni par la source)

Bipolar‐associated miR‐499‐5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2

Helena Caria Martins, Carlotta Gilardi, Ayse Özge Sungur, Jochen Winterer et autres

Bipolar disorder (BD) is a chronic mood disorder characterized by manic and depressive episodes. Dysregulation of neuroplasticity and calcium homeostasis are frequently observed in BD patients, but the underlying molecular mechanisms are largely unknown. Here, we show that miR-499-5p regulates dendritogenesis and …

ch, de, pl, be (code pays fourni par la source)