Greg Dyson

Proteogenomic profiling defines progression-associated biology in high-risk endometrial cancer

G. Larry Maxwell, Nicholas W. Bateman, Kathleen M. Darcy, Chunqiao Tian et autres

Patients with high-risk endometrial carcinoma (HR-EC) experience substantial mortality despite multimodality therapy, molecular classification and contemporary care. We determined whether proteomic tumor programs capture lethal risk beyond established clinical and genomic classifiers and may inform translational investigations. We performed integrated clinical, genomic, …

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Opposing Effects of Metoclopramide and Bromocriptine on Melanoma Response to Immune Checkpoint Blockade 2303237

Mark Gregory, Justin Hackett, Greg Dyson, Heather Gibson

Abstract Introduction Dual immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1 have been effective in treating advanced melanoma, yet the melanoma-specific survival is only ∼52%. The human population is genetically heterogeneous, and we hypothesize that this contributes to the disparate response to …

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Development and Characterization of a Novel Congenital Acute Erythroid Leukemia Cell Line with Unique Features

Prasiksha Sitaula, Manisha Gadgeel, Holly Edwards, Lisa Polin et autres

Background: Acute erythroid leukemia (AEL) or AML-M6 predominantly affects older adults and is rare in childhood. Compared with other AML subtypes, AEL remains relatively understudied because of its rarity. We established LS-CHM, a novel AEL cell line derived from the ascitic fluid …

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Development and validation of prognostic biomarkers to enhance clinical triage in high-risk endometrial carcinoma

George Maxwell, Kathleen Darcy, Chunqiao Tian, Douglas Craig et autres

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Abstract 2295: KMT2D loss rewires estrogen-PI3K crosstalk in endometrioid adenocarcinoma

Jessica L. Long, Swornalata Pukhrambam, Areebah Qazi, Michele L. Coté et autres

Abstract BACKGROUND: Endometrioid adenocarcinoma is defined by pervasive PI3K-pathway dysregulation and estrogen-driven growth. More than 80% of tumors harbor PI3K-pathway alterations, and approximately 20% exhibit loss-of-function mutations in the histone methyltransferase KMT2D, often at high variant allele frequencies, suggesting biological relevance rather …

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Pharmacologic targeting of the dopamine D2 receptor impacts the efficacy of immune checkpoint blockade in melanoma

Mark Gregory, Justin B. Hackett, S. Hughes, Maria Carolina Rocha Muniz et autres

BACKGROUND: Immune checkpoint inhibitors (ICIs) have been successful in treating advanced melanoma, yet, the 10-year melanoma-specific survival is only 52%. Our prior work using genetic linkage analysis revealed that the murine prolactin (PRL) locus associates with ICI response in C57BL/6 (B6)-syngeneic B16F0 …

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TGFBR1 *6A and Risk for Colorectal Cancer

Allan M. Johansen, Julie T. Ziegler, Kojo Agyemang, Michael J. Pennison et autres

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Targeting the dopamine D2 receptor influences response to immune checkpoint inhibitor therapy of melanoma 2787

Mark Gregory, Justin B. Hackett, Greg Dyson, Heather M. Gibson

Abstract Description Immune checkpoint inhibitors (ICIs) have been effective in treating advanced melanoma, yet the objective response rate is only ∼52%. We hypothesize that germline genetic heterogeneity contributes to disparate ICI response. This is supported by our previous work showing that genetically …

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Functional genomics in Diversity Outbred mice identifies Hmgb2 as a candidate regulator of immune checkpoint inhibitor response in melanoma 4592

S. Hughes, Justin B. Hackett, Mark Gregory, Greg Dyson et autres

Abstract Description Our prior studies show that host genetics play a role in response to cancer immunotherapy treatment. Diversity Outbred mice crossed with C57BL/6 mice (DOxB6F1) were inoculated with B16 melanoma and treated with immune checkpoint inhibitors (ICI) anti-PD-1 and anti-CTLA-4. These …

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Abstract 2716: Role for KMT2C mutation in endometrial cancer pathogenesis

Swornalata Pukhrambam, Sophia Agrusa, Jessica B. Back, Greg Dyson et autres

Abstract Background: Endometrial cancer (EC) is the 4th most common cancer to be diagnosed in women. Although EC has reasonable survival rates, there is a disparity gap for African American (AA) women, as they are twice as likely to succumb to metastatic …

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Dual activity of Minnelide chemosensitize basal/triple negative breast cancer stem cells and reprograms immunosuppressive tumor microenvironment

Fulya Koksalar Alkan, Ahmet B. Çağlayan, Hilmi Kaan Alkan, Elayne M. Benson et autres

Triple negative breast cancer (TNBC) subtype is characterized with higher EMT/stemness properties and immune suppressive tumor microenvironment (TME). Women with advanced TNBC exhibit aggressive disease and have limited treatment options. Although immune suppressive TME is implicated in driving aggressive properties of basal/TNBC …

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225P Nuclear exporter protein exportin 1 (XPO1) as a novel therapeutic target in pancreatic neuroendocrine tumors

Asfar Sohail Azmi, Md. Hafiz Uddin, Sahar F. Bannoura, Haji Muhammad Shoaib Khan et autres

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