Heather M. Gibson

Single-nuclei RNA sequencing reveals obesity-associated rewiring of estrogen signaling in endometrioid adenocarcinoma

Jessica L. Long, Sophia Agrusa, Swornalata Pukhrambam, Sanjeev Ganesh et autres

Endometrioid adenocarcinoma has one of the strongest body mass index associations of any solid tumor. This is widely attributed to amplification of estrogen-driven signaling via increased production of unopposed estrogen in peripheral adipose tissue. However, there is little evidence as to whether …

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Opportunities to Enhance Cancer Research through Advocate–Researcher Partnerships

Sarah B. Gitto, Savannah J. Hughes, Marcie Paul, Sadhana Bom et autres

People who have experienced cancer are integral partners in the research process and improving standard-of-care treatments. Advocates contribute insights from lived experience that help researchers identify impactful scientific priorities, improve study design, and enhance clinical trial participation. Although programs have been established …

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Pharmacologic targeting of the dopamine D2 receptor impacts the efficacy of immune checkpoint blockade in melanoma

Mark Gregory, Justin B. Hackett, S. Hughes, Maria Carolina Rocha Muniz et autres

BACKGROUND: Immune checkpoint inhibitors (ICIs) have been successful in treating advanced melanoma, yet, the 10-year melanoma-specific survival is only 52%. Our prior work using genetic linkage analysis revealed that the murine prolactin (PRL) locus associates with ICI response in C57BL/6 (B6)-syngeneic B16F0 …

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Ruthenium-BODIPY photodynamic therapy for induction of immunogenic cell death and anti-tumor immunity 4628

Alexander Ullrich, Nicholas P. Toupin, Madeline Denison, Mackenzie K. Herroon et autres

Abstract Description Solid tumors that have low T cell infiltration may benefit from therapies that prime anti-tumor immunity. We are developing photodynamic therapy (PDT) agents that induce immunogenic cell death (ICD), engage macrophages (Mφ), and stimulate adaptive anti-tumor immunity. PDT works by …

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Targeting the dopamine D2 receptor influences response to immune checkpoint inhibitor therapy of melanoma 2787

Mark Gregory, Justin B. Hackett, Greg Dyson, Heather M. Gibson

Abstract Description Immune checkpoint inhibitors (ICIs) have been effective in treating advanced melanoma, yet the objective response rate is only ∼52%. We hypothesize that germline genetic heterogeneity contributes to disparate ICI response. This is supported by our previous work showing that genetically …

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Functional genomics in Diversity Outbred mice identifies Hmgb2 as a candidate regulator of immune checkpoint inhibitor response in melanoma 4592

S. Hughes, Justin B. Hackett, Mark Gregory, Greg Dyson et autres

Abstract Description Our prior studies show that host genetics play a role in response to cancer immunotherapy treatment. Diversity Outbred mice crossed with C57BL/6 mice (DOxB6F1) were inoculated with B16 melanoma and treated with immune checkpoint inhibitors (ICI) anti-PD-1 and anti-CTLA-4. These …

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Building research infrastructure to advance precision medicine in colorectal cancer

Stephanie L. Schmit, Nicole C. Loroña, Daniel Sobieski, Hannah J. Hoehn et autres

BACKGROUND: Addressing critical gaps in precision medicine initiatives in colorectal cancer (CRC) requires building larger collaborative studies. METHODS: The Latino Colorectal Cancer Consortium (LC3) is a resource that harmonizes data collected in observational studies with data from individuals who identify as Hispanic/Latino …

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Data from Evaluation of the Immune Response within the Tumor Microenvironment in African American and Non-Hispanic White Patients with Non–Small Cell Lung Cancer

Matthew R. Trendowski, Donovan Watza, Christine M. Lusk, Fulvio Lonardo et autres

AbstractBackground: African Americans have higher incidence and mortality from lung cancer than non-Hispanic Whites, but investigations into differences in immune response have been minimal. Therefore, we compared components of the tumor microenvironment among African Americans and non-Hispanic Whites diagnosed with non–small cell …

Supplementary Table S1 from Evaluation of the Immune Response within the Tumor Microenvironment in African American and Non-Hispanic White Patients with Non–Small Cell Lung Cancer

Matthew R. Trendowski, Donovan Watza, Christine M. Lusk, Fulvio Lonardo et autres

Clinical and Demographic Characteristics by PD-L1 and TLS Status.

Supplementary Table S8 from Evaluation of the Immune Response within the Tumor Microenvironment in African American and Non-Hispanic White Patients with Non–Small Cell Lung Cancer

Matthew R. Trendowski, Donovan Watza, Christine M. Lusk, Fulvio Lonardo et autres

Differential Expression of B Cell-related Transcripts by Race.

Supplementary Table S1 from Evaluation of the Immune Response within the Tumor Microenvironment in African American and Non-Hispanic White Patients with Non–Small Cell Lung Cancer

Matthew R. Trendowski, Donovan Watza, Christine M. Lusk, Fulvio Lonardo et autres

Clinical and Demographic Characteristics by PD-L1 and TLS Status.

Supplementary Table S2 from Evaluation of the Immune Response within the Tumor Microenvironment in African American and Non-Hispanic White Patients with Non–Small Cell Lung Cancer

Matthew R. Trendowski, Donovan Watza, Christine M. Lusk, Fulvio Lonardo et autres

Overall Survival by PD-L1 and TLS Status.