Qu Leng

CircPPFIA2 drives prostate cancer progression and enzalutamide resistance by sponging miR-646 and miR-1200 to upregulate ETS1

Yiyou Mao, Qu Leng, Jun Wu, Wenbin Chen et autres

Prostate cancer (PCa) represents a leading cause of cancer-related morbidity in men worldwide, necessitating deeper insights into its molecular drivers. Circular RNAs (circRNAs) are increasingly recognized as key regulatory molecules in carcinogenesis; however, their functional significance in PCa pathogenesis and treatment resistance …

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Biparametric MRI-based radiomics for noninvastive discrimination of benign prostatic hyperplasia nodules (BPH) and prostate cancer nodules: a bio-centric retrospective cohort study

Yangbai Lu, Runqiang Yuan, Yun Su, Zhiying Liang et autres

To investigate the potential of an MRI-based radiomic model in distinguishing malignant prostate cancer (PCa) nodules from benign prostatic hyperplasia (BPH)-, as well as determining the incremental value of radiomic features to clinical variables, such as prostate-specific antigen (PSA) level and Prostate …

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Establishment and Validation of a Machine Learning Model Predicting Post-Radical Prostatectomy Gleason grading group upgrading Author’s information

Jinfeng Wu, Runqiang Yuan, Yangbai Lu, Jianjun Tan et autres

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Biparametric MRI-based radiomics for noninvastive discrimination of benign and malignant prostate nodules: A bio-centric retrospective cohort study

Yangbai Lu, Run-qiang Yuan, Yun Su, Zhiying Liang et autres

Abstract Background To investigate the potential of an MRI-based radiomic model in distinguishing malignant prostate nodules from benign ones, as well as determining the incremental value of radiomic features to clinical variables, such as prostate-specific antigen (PSA) level and Prostate Imaging Reporting …

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Biparametric MRI-based radiomics classifiers for the detection of prostate cancer in patients with PSA serum levels of 4∼10 ng/mL

Yangbai Lu, Binfei Li, Hongxing Huang, Qu Leng et autres

Purpose To investigate the predictive performance of the combined model by integrating clinical variables and radiomic features for the accurate detection of prostate cancer (PCa) in patients with prostate-specific antigen (PSA) serum levels of 4-10 ng/mL. Methods A retrospective study of 136 …

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Survival Analysis and a Novel Nomogram Model for Progression-Free Survival in Patients with Prostate Cancer

Yuefu Han, Xingqiao Wen, Dong Chen, Xiaojuan Li et autres

Background: This study sought to perform a survival analysis and construct a prognostic nomogram model based on the Gleason grade, total prostate-specific antigen (tPSA), alkaline phosphate (ALP), and TNM stage in patients with prostate cancer (PCa). Methods: The progression-free survival (PFS) of …

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GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway

Wenjie Lai, Weian Zhu, Xiaojuan Li, Yuefu Han et autres

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Comparison of intravesical instillation of hyaluronic acid with intradetrusor botulinum toxin A injection or cystoscopic hydrodistention for ketamine-associated cystitis

Bingkun Li, Qu Leng, Chuanyin Li, Xiao Tan et autres

OBJECTIVE: This study aimed to compare the therapeutic effect of intravesical instillation hyaluronic acid with intradetrusor botulinum toxin A (BTX-A) injection or cystoscopic hydrodistention for ketamine-associated cystitis. METHODS: Thirty-six patients were evenly randomly divided into the BTX-A group or the hydrodistention group. …

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Microstructures of the spermatic cord with three-dimensional reconstruction of sections of the cord and application to varicocele

Yu Yang, Xiaoqiang Wu, Qu Leng, Wei Su et autres

The aim of the study was to investigate the micro-structures of the spermatic cord using histological examination with three-dimensional (3D) reconstruction of the serial tissue sections of the cord for clinical application in microscopic varicocelectomy. Human spermatic cord specimens obtained from 13 …

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[Video endosopic inguinal lymphadenectomy for penile cancer].

Qu Leng, Bingkun Li, Xiangming Mao

Inguinal lymph node metastasis is one of the important factors affecting the prognosis of penile cancer. Conventional open inguinal lymphadenectomy, with a high rate of complications, seriously affects the effect of surgery and the patient's quality of life, and therefore is rarely …

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MicroRNA‐488 inhibits proliferation and glycolysis in human prostate cancer cells by regulating PFKFB3

Jun Wang, Xiaojuan Li, Zhaoming Xiao, Yu Wang et autres

Prostate cancer (PCa) remains the second leading cause of cancer-related death among men in the United States, and its molecular mechanism remains to be elucidated. Recent studies have suggested that microRNAs may play an important role in cancer development and progression. By …

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Correlation of clinical features and different clinical stages with body mass index in patients of prostate cancer

Jun Li, Qu Leng, Zhaoming Xiao, Han Yue-fu et autres

Objective To retrospectively analyze the different clinical stages of patients with prostate cancer, and to investigate it’s correlation with body mass index (BMI). Methods 363 patients with prostate cancer were enrolled from January 2008 to December 2016. There were 141 cases of …

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