Weian Zhu

Dual-region deep learning model integrating prostate and peri-prostatic adipose tissue MRI features for bone metastasis prediction in prostate cancer

Peng Qin, Bohao Liu, Huabin Su, Ziqiao Wang et autres

Rationale and objectives Bone metastasis (BM) is pivotal in prostate cancer (PCa) management. This study developed a multimodal model integrating MRI-derived deep features from the prostate gland (PG) and periprostatic adipose tissue (PPAT) with clinical variables for BM risk assessment. Methods Retrospectively, …

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A nomogram based on radiomic features from peri-prostatic adipose tissue for predicting bone metastasis in first-time diagnosed prostate cancer patients

Bohao Liu, Qian Cai, Xiao Zhao, Huabin Su et autres

PURPOSE: To evaluate a radiomics-based nomogram using peri-prostatic adipose tissue (PPAT) features for predicting bone metastasis (BM) in newly diagnosed prostate cancer (PCa) patients. METHODS: A retrospective study of 151 PCa patients (October 2010-November 2022) was conducted. Radiomic features were extracted from …

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The global burden of smoking-related prostate cancer from 1990 to 2021 and projections to 2031

Bohao Liu, Chen Zou, Huabin Su, Xiao Zhao et autres

INTRODUCTION: Smoking is a significant risk factor for prostate cancer (PCa), a major health threat for aging males globally. This study evaluates the worldwide burden of smoking-related PCa from 1990 to 2021 and projects trends to 2031. METHODS: Using Global Burden of …

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UHMK1 Promotes Prostate Cancer Progression through a Positive Feedback Loop with MTHFD2

Chi Zhang, Xi Huang, Cheng Hu, Bowen Tang et autres

Background: U2AF homology motif kinase 1 (UHMK1) has been associated with RNA processing and protein phosphorylation, thereby influencing tumor progression. The study aimed to explore its regulatory mechanisms and biological functions in human prostate cancer (PCa). Methods: . Additionally, a series of …

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Modeling and Characteristic Test for a Crank-Connecting Rod Mem-Inerter Device

Xiaoliang Zhang, Yalin Chen, Jiamei Nie, Weian Zhu

This paper presents a mechanical crank-connecting rod mem-inerter device, with its output and memory characteristics being investigated and validated. Previous research suggests that a hydraulic mem-inerter generates a sizeable damping force, practically transforming it into a mem-dashpot. This greatly influences a system’s …

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Harnessing machine learning and multi-omics to explore tumor evolutionary characteristics and the role of AMOTL1 in prostate cancer

Weian Zhu, Jianjie Wu, Wenjie Lai, Fengao Li et autres

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HJURP inhibits sensitivity to ferroptosis inducers in prostate cancer cells by enhancing the peroxidase activity of PRDX1

Wenjie Lai, Weian Zhu, Jianjie Wu, Jiongduan Huang et autres

residues. This disulfide binding promotes PRDX1 redox cycling and inhibits its hyperoxidation. As a result, HJURP enhances the peroxidase activity of PRDX1, leading to a decrease in ROS levels and subsequently suppressing lipid peroxidation induced by ferroptosis inducers. These findings reveal the …

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Comparative efficacy of commercial oral poly-herbal traditional Chinese medicine formulations combined with western medicine in benign prostatic hyperplasia management: a systematic review and network meta-analysis

Hengda Zeng, Ziqiao Wang, Weian Zhu, Xiaoyang Li et autres

Background: Benign prostatic hyperplasia (BPH) is prevalent among the aging male population and often presents with distressing lower urinary tract symptoms. There is emerging evidence that commercial oral poly-herbal traditional Chinese medicine (TCM) formulation combined with Western medicine (WM) may offer enhanced …

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Measurements of peri-prostatic adipose tissue by MRI predict bone metastasis in patients with newly diagnosed prostate cancer

Bohao Liu, Yunhua Mao, Xiaoyang Li, Rui-Xiang Luo et autres

Objectives: To investigate the role of MRI measurements of peri-prostatic adipose tissue (PPAT) in predicting bone metastasis (BM) in patients with newly diagnosed prostate cancer (PCa). Methods: We performed a retrospective study on 156 patients newly diagnosed with PCa by prostate biopsy …

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Integrated machine learning identifies epithelial cell marker genes for improving outcomes and immunotherapy in prostate cancer

Weian Zhu, Hengda Zeng, Jiongduan Huang, Jianjie Wu et autres

BACKGROUND: Prostate cancer (PCa), a globally prevalent malignancy, displays intricate heterogeneity within its epithelial cells, closely linked with disease progression and immune modulation. However, the clinical significance of genes and biomarkers associated with these cells remains inadequately explored. To address this gap, …

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Inflammation-related signature for prognostic prediction, tumor immune, genomic heterogeneity, and drug choices in prostate cancer: Integrated analysis of bulk and single-cell RNA-sequencing

Weian Zhu, Jiongduan Huang, Jianjie Wu, Cheng-Lun Wu et autres

Background: Prostate cancer (PCa) ranks as the second most prevalent malignancy among males on a global scale. Accumulating evidence suggests that inflammation has an intricate relationship with tumorigenesis, tumor progression and tumor immune microenvironment. However, the overall impact of inflammation-related genes on …

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Multi-omics analysis reveals a macrophage-related marker gene signature for prognostic prediction, immune landscape, genomic heterogeneity, and drug choices in prostate cancer

Weian Zhu, Jianjie Wu, Jiongduan Huang, Dongming Xiao et autres

Introduction: Macrophages are components of the innate immune system and can play an anti-tumor or pro-tumor role in the tumor microenvironment owing to their high heterogeneity and plasticity. Meanwhile, prostate cancer (PCa) is an immune-sensitive tumor, making it essential to investigate the …

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