Dong Chen

Emergence of Ceftazidime‐Avibactam‐Induced KPC Variants (KPC‐25/127) in Intracranial Infection and Implications for Clinical Management

Ke Lei, Ying Tian, Chaoliang Xiong, Jing Lei et autres

ABSTRACT The emergence of novel Klebsiella pneumoniae carbapenemase (KPC) variants contributing to clinical treatment failure poses a substantial threat to public health. To inform the clinical management of infections caused by KPC‐variant‐harboring K. pneumoniae , this study reports the complex evolutionary trajectory …

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Case Report: Carotid body paraganglioma in a 20-year-old woman: multimodal imaging, vessel-preserving surgical excision, and long-term clinical follow-up

Weixu Zhou, Dong Chen, Xianwei Wang

Carotid body paraganglioma is a rare hypervascular neuroendocrine tumor of the head and neck, and presentation in a 20-year-old woman is uncommon. We report a young woman with a painless left lateral neck mass present for more than 5 years, with more …

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Dynamic Evolution of Gas–Water Displacement and Microscopic Fluid Occurrence in Deep Coalbed Methane

Yuan Wang, Dong Chen, Wei Sun, Yanqing Feng et autres

Deep coalbed methane (CBM) has become an important contributor to natural gas production worldwide. Its fluid occurrence characterized by high free gas content and low water saturation suggests substantial gas-driven displacement caused by hydrocarbon generation overpressure. However, the microscopic evolution of this …

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Abstract PS3-11-05: Trastuzumab Combined with Pyrotinib and Capecitabine as Postoperative Adjuvant Therapy in Non-Pathological Complete Response HER2-Positive Early Breast Cancer Following Neoadjuvant Therapy: A Multicenter Phase II Study

C. Wang, F. Fu, J. Zhang, S. Lin et autres

Abstract Background: HER2-positive early breast cancer patients achieving a pathological complete response (pCR) during neoadjuvant therapy demonstrate a more favorable prognosis. The KATHERINE study indicated that for HER2-positive early breast cancer patients who did not achieve pCR (the presence of residual tumor …

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Sex-specific association of the hemoglobin, albumin, lymphocyte, and platelet score with urinary incontinence: A cross-sectional study

Jiasheng Liu, Jinhao Li, Pengfei Diao, Dong Chen et autres

Urinary incontinence (UI) significantly impairs patients' normal social activities and physical exercise, posing a major public health and socioeconomic challenge. The association between the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and UI has not been extensively investigated, with few studies examining …

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Surgical intervention strategies for tumor microenvironment (TME) associated therapeutic resistance

Dong Chen, Hanyu Wang, Xu Che

The tumor microenvironment (TME) drives therapeutic resistance through immunosuppression, stromal remodeling, and metabolic reprogramming, which pose a major challenge in solid tumor treatment. While surgery remains a cornerstone for tumor eradication, perioperative inflammatory responses and ischemia-reperfusion injuries may exacerbate TME deterioration. However, …

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Evaluation of platelet dense granules by transmission electron microscopy in healthy pediatric donors and pediatric patients with suspected platelet disorders

Jacob R. Greenmyer, Dong Chen, Kyle G. Howell, Karen M. Fischer et autres

Background Whole mount (WM) platelet transmission electron microscopy (PTEM) is a standard method for evaluating platelet dense granules (DG). However, because of the lack of a pediatric/adolescent mean DG/platelet reference range (RR), the prevalence of platelet DG deficiency in patients with suspected …

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Anti-platelet factor 4 antibodies in MGUS-related thrombosis

Adam J. Kanack, Noah P. Splinter, Damon E. Houghton, Emily Mauch et autres

Abstract Introduction: Monoclonal gammopathy of thrombotic significance (MGTS) is a recently recognized thrombophilia where monoclonal platelet factor 4 (PF4)-specific IgG antibodies initiate a chronic prothrombotic state characterized by recurrent and potentially life-threatening thrombosis. Studies from large data sets demonstrate that patients with …

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KT ‐939: A Next‐Generation Human Tyrosinase Inhibitor With Superior Efficacy for the Safe Management of Hyperpigmentation

Xiaodan Hou, Y. Li, Qun Zhang, Honghua Yan et autres

BACKGROUND: Tyrosinase is the rate-limiting enzyme in melanin biosynthesis, and its overactivity contributes to hyperpigmentation disorders. Existing tyrosinase inhibitors are often limited by poor potency against human tyrosinase (hTYR) or safety concerns. AIMS: To evaluate the inhibitory potency, safety, and multifunctional activity …

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Achievable rate maximization for UAV-mounted IRS-assisted MIMO systems

Qian Zeng, Dong Chen, Wei Geng, ThiOanh Bui et autres

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Hepatic aconitase 1 redirects citrate flux to suppress lipogenesis and ameliorate hypercholesterolemia

Linyi Li, Yu Wang, Zhiyong Du, Huahui Yu et autres

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Low-Dose Radiotherapy Modulates Dendritic Cell Metabolism to Reprogram the Tumor Immune Microenvironment

Yuxin Zhou, J. Yuan, Sheng Yang, Bofu Liu et autres