Linlin Niu

Aurantio-Obtusin Attenuates Aβ-Induced Cognitive Impairment and Synaptic Dysfunction by Suppressing Neuroinflammation in Mice

Xueying Feng, Wei Yu, Song Guo, Yanyan Ji et autres

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CD23 sustains NKT17 cell homeostasis via IL-7Rα-mTORC2 signaling

Linlin Niu, Bingqian Tan, Jingting Xu, G L Zhang et autres

Invariant natural killer T (iNKT) cells serve as a crucial bridge between innate and adaptive immunity, yet the molecular mechanisms that sustain their subset homeostasis remain incompletely defined. Here, we identify CD23 (FcεRII) as a previously unrecognized intrinsic regulator of NKT17 cell …

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Low levels of CD39+ Tregs may predict poor outcome in children with sepsis

Yan-Chun Ji, Chenhao Wang, Bo Wang, Jingting Xu et autres

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Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway

Guojin Wu, Y. Zhang, Linlin Niu, Yuan Hu et autres

BACKGROUND: Human metapneumovirus(hMPV) is one of the most common viruses that cause acute lower respiratory tract infections. Interleukin-1β (IL-1β) has been reported to play an important role in multiple virus replication. Patients with hMPV infection have increased levels of IL-1β which reminds …

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Biosynthesis of Glucaric Acid by Recombinant Strain of Escherichia coli Expressing Two Different Urinate Dehydrogenases

Xinchao Yang, Linlin Niu, Chunjiang Ye, Yuanxiu Wang et autres

D-glucaric acid is an important bio-based building block of polymers and is a high value-added chemical that can be used in a variety of applications. In the present study, the Udh target genes from Pseudomonas putida and Pseudomonas syringae were used together …

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Biosynthesis of Glucaric Acid by Recombinant Strain of Escherichia coli Expressing Two Different Urinate Dehydrogenases

Xinchao Yang, Linlin Niu, Chunjiang Ye, Yuanxiu Wang et autres

D-Glucaric acid is an important bio-based building block of polymers and is a high value-added chemical that can be used in a variety of applications. In the present study, the Udh target genes from Pseudomonas putida and Pseudomonas syringae were used together …

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Interleukin-4 Promotes Human Metapneumovirus Replication Through the JAK/STAT6 Pathway

Y. Zhang, Guojin Wu, Yuting Yang, Linlin Niu et autres

Respiratory virus infections are the main causes of pediatric diseases. Human metapneumovirus (hMPV) is an enveloped RNA virus similar to severe acute respiratory syndrome coronavirus type 2, both of which have emerged as important new respiratory viruses. Recent studies have found that …

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Cadherin Is a Binding Protein but Not a Functional Receptor of Bacillus thuringiensis Cry2Ab in Helicoverpa armigera

Zaw Lin Naing, Ei Thinzar Soe, Caihong Zhang, Linlin Niu et autres

To improve the efficiency of production of a single toxin in crops and to delay the evolution of insect resistance to the toxin, the second generation of Bt cotton, expressing Cry1Ac and Cry2Ab, was introduced. Understanding the mode action of the Cry …

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Interleukin-1β Promotes Human Metapneumovirus Replication Via Activating the CGAS-STING Pathway

Guojin Wu, Y. Zhang, Linlin Niu, Yuan Hu et autres

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Progranulin regulates the development and function of NKT2 cells through EZH2 and PLZF

Zuochen Du, Lu Huang, Xin Dai, Di Yang et autres

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Assessment of the potential toxicity of insecticidal compounds to Peristenus spretus, a parasitoid of mirid bugs

Man Zhao, Yunhe Li, Linlin Niu, Lin Chen

With the increased cultivation of Bt crops in China, Apolygus lucorum and other mirid bugs have emerged as important agricultural pests because they are insensitive to the Bt proteins. In addition, the reduction of pesticide applications after planting Bt crops also increases …

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WASp Deficiency Selectively Affects the TCR Diversity of Different Memory T Cell Subsets in WAS Chimeric Mice

Wenyan Li, Yanjun Jia, Yanping Wang, Qin Zhao et autres

Background The T cell receptor (TCR) diversity is essential for effective T cell immunity. Previous studies showed that TCR diversity in Wiskott–Aldrich Syndrome (WAS) patients was severely impaired, especially in the memory T cell populations. Whether this defect was caused by intrinsic …

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