Jingting Xu

CD23 sustains NKT17 cell homeostasis via IL-7Rα-mTORC2 signaling

Linlin Niu, Bingqian Tan, Jingting Xu, G L Zhang et autres

Invariant natural killer T (iNKT) cells serve as a crucial bridge between innate and adaptive immunity, yet the molecular mechanisms that sustain their subset homeostasis remain incompletely defined. Here, we identify CD23 (FcεRII) as a previously unrecognized intrinsic regulator of NKT17 cell …

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609 Restoring immune responsiveness in periphery and tumor with mRNA-4359, an mRNA-based therapy encoding PD-L1 and IDO1 peptides, plus pembrolizumab in checkpoint inhibitor resistant/refractory melanoma

Debashis Sarker, Georgina V. Long, David J. Pinato, Adnan Khattak et autres

Background mRNA-4359 is an investigational immunotherapy designed to activate antigen-specific T cells that target both PD-L1 and IDO1 expressed by tumor and immunosuppressive cells. By promoting T-cell responses and reshaping the tumor microenvironment (TME), mRNA-4359 may enhance the efficacy of immune checkpoint …

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Low levels of CD39+ Tregs may predict poor outcome in children with sepsis

Yan-Chun Ji, Chenhao Wang, Bo Wang, Jingting Xu et autres

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TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway

Kai Sun, Xiong Zhang, Liangcai Hou, Fan Lü et autres

INTRODUCTIONS: Osteoarthritis (OA) is a significant contributor to disability in the elderly population. However, current therapeutic options are limited. The transient receptor potential melastatin 2 (TRPM2) is involved in a range of disease processes, yet its role in OA remains unclear. OBJECTIVES: …

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Corrigendum to “Deferoxamine alleviates chondrocyte senescence and osteoarthritis progression by maintaining iron homeostasis” [139 (2024) 112619]

Zhou Guo, Yang Lin, Haigang Liu, Jiachao Guo et autres

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Deferoxamine Alleviates Chondrocyte Senescence and Osteoarthritis Progression by Maintaining Iron Homeostasis

Yang Lin, Haigang Liu, Jiachao Guo, Mi Li et autres

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Desferoxamine protects against hemophilic arthropathy through the upregulation of HIF-1α-BNIP3 mediated mitophagy

Jiamin Lin, Zehang Zheng, Liangcai Hou, Jingting Xu et autres

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Iron homeostasis in arthropathies: From pathogenesis to therapeutic potential

Kai Sun, Liangcai Hou, Jingting Xu, Ting Du et autres

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Hydrogen: An Endogenous Regulator of Liver Homeostasis

Yaxing Zhang, Jingting Xu, Hongzhi Yang

Basic and clinical studies have shown that hydrogen (H2), the lightest gas in the air, has significant biological effects of anti-oxidation, anti-inflammation and anti-apoptosis. The mammalian cells have no abilities to produce H2 due to lack of the expression of hydrogenase. The …

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Ferroptosis induction induced by ginkgetin enhances therapeutic effect of cisplatin in EGFR wild type non-small cell lung cancer

Jian-Shu Lou, Liping Zhao, Xia-Yin Chen, Jingting Xu et autres

Abstract Background Cisplatin (DDP) is the first-in-class drug for advanced and non-targetable non-small cell lung cancer (NSCLC). Recent study indicates that DDP could slightly induce non apoptotic cell death ferroptosis, and the cytotoxicity was promoted by ferroptosis inducer. The agents enhancing ferroptosis …

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Helium Protects against Lipopolysaccharide-Induced Cardiac Dysfunction in Mice via Suppressing Toll-Like Receptor 4-Nuclear Factor κB-Tumor Necrosis Factor-Alpha/ Interleukin-18 Signaling

Yaxing Zhang, Jiongshan Zhang, Kangquan Xu, Zifeng Chen et autres

The nonanesthetic noble gas helium (He) can protect many organs against ischemia and reperfusion injury, such as liver and heart. However, the role of He on cardiac dysfunction during sepsis is not clear. In this study, we established a lipopolysaccharide (LPS)-induced cardiac …

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H2 Protects Against Lipopolysaccharide-Induced Cardiac Dysfunction via Blocking TLR4-Mediated Cytokines Expression

Sihua Tan, Zhiyuan Long, Xiangping Hou, Yujie Lin et autres

BACKGROUND AND PURPOSE: Septic cardiomyopathy, which is one of the features of multi-organ dysfunction in sepsis, is characterized by ventricular dilatation, reduction in ejection fraction and reduced contractility, and if severe, can lead to death. To date, there is no specific therapy …

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