Jennifer Hopwood

ChemInform Abstract: A Regio‐ and Stereoselective ω‐Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5‐Disubstituted Pyrrolidines.

Elaine O’Reilly, César Iglesias, Diego Ghislieri, Jennifer Hopwood et autres

Abstract The chemoselective reductive cyclization of diones of type (I) in the presence of transaminase ATA113 is presented.

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A Regio‐ and Stereoselective ω‐Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5‐Disubstituted Pyrrolidines

Elaine O’Reilly, César Iglesias, Diego Ghislieri, Jennifer Hopwood et autres

Biocatalytic approaches to the synthesis of optically pure chiral amines, starting from simple achiral building blocks, are highly desirable because such motifs are present in a wide variety of important natural products and pharmaceutical compounds. Herein, a novel one-pot ω-transaminase (TA)/monoamine oxidase …

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A Regio‐ and Stereoselective ω‐Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5‐Disubstituted Pyrrolidines

Elaine O’Reilly, César Iglesias, Diego Ghislieri, Jennifer Hopwood et autres

Abstract Biocatalytic approaches to the synthesis of optically pure chiral amines, starting from simple achiral building blocks, are highly desirable because such motifs are present in a wide variety of important natural products and pharmaceutical compounds. Herein, a novel one‐pot ω‐transaminase (TA)/monoamine …

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Development of transaminases for the synthesis of enantiomerically pure chiral amines

Jennifer Hopwood

Enantiomerically pure amines have a variety of industrial applications. They are valuable components within the pharmaceutical and agrochemical industry, resolving agents for separation of racemic mixtures by dimeric salt formation and ligands for transition metal catalysts and chemocatalysts. Biocatalysis is increasingly seen …

Structures of a γ-aminobutyrate (GABA) transaminase from thes-triazine-degrading organismArthrobacter aurescensTC1 in complex with PLP and with its external aldimine PLP–GABA adduct

Heather A. Bruce, Juan Mangas‐Sánchez, Charlotte Leese, Jennifer Hopwood et autres

Two complex structures of the γ-aminobutyrate (GABA) transaminase A1R958 from Arthrobacter aurescens TC1 are presented. The first, determined to a resolution of 2.80 Å, features the internal aldimine formed by reaction between the ℇ-amino group of Lys295 and the cofactor pyridoxal phosphate …

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Reductive Amination

Simon C. Willies, Matthew D. Truppo, Christopher K. Savile, Jacob M. Janey et autres

This chapter contains sections titled: ω-Transaminases – Useful Biocatalysts for Chiral Amine Synthesis Preparative Scale Production of a Bulky–Bulky Chiral Amine Using an Engineered Transaminase Synthesis of Optically Pure Amines Employing ω-Transaminases A Fast, Sensitive Assay and Scale-Up of ω-Transaminase Catalysed Reactions …

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A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases

Jennifer Hopwood, Matthew D. Truppo, Nicholas J. Turner, Richard C. Lloyd

A fast and sensitive method for screening transaminase activity and enantioselectivity, using D- and L-amino acid oxidases, allows new amine substrates to be rapidly identified.

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