Amir Ali Hamidieh

Establishing the First National Fanconi Anemia Registry in Iran: Clinical and Epidemiological Insights From 116 Patients

Amir Ali Hamidieh, Mina Mokaram, Amirali Kalantari, Leila Jafari et autres

BACKGROUND: Fanconi anemia (FA) is the most common inherited bone marrow failure syndrome. Iran, with a high rate of consanguineous marriage and considerable ethnic diversity, represents a high-risk context for FA. We established the Iranian Fanconi Anemia Registry (IRFAR) to provide the …

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Cord Blood‐Derived Platelet Gel in Wound Healing: From Biological Rationale to Clinical Application

Amirali Kalantari, Zahra Karimizadeh, Atoosa Eftekhar, Rashin Mohseni et autres

Chronic and complex wounds are a major burden worldwide, and a considerable number remain unresponsive to traditional therapy. Cord blood-derived platelet gel (CBPG) is a novel allogeneic wound therapy providing a fibrin-based scaffold enriched with neonatal platelet-derived growth factors, including high concentrations …

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Patient-derived organoids as a predictive platform for drug sensitivity in bladder cancer

Shirin Hekmatirad, Fatemeh Gholizadeh, Saeed Montazeri, Laleh Sharifi et autres

Bladder cancer (BC) exhibits high inter- and intra-patient heterogeneity, limiting the efficacy of standard treatments and underscoring the need for personalized therapeutic models. We established patient-derived organoids (PDOs) from 31 clinical BC specimens, achieving an 80.65% success rate. These organoids preserved distinct …

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Impact of CMV infection on pediatric allogeneic HSCT outcomes in a region of high CMV seroprevalence: a non-TBI cohort study

Atieh Karimzadeh, Sadaf Setareh Azar, Yalda Karamlou, Amirali Kalantari et autres

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Behavior of flow rate and rotational speed in blood components separation: an engineering approach to apheresis procedure

Shafie Rahmati, Amir Ali Hamidieh, Maryam Behfar, Leila Jafari et autres

Performance of centrifugal blood component separators in apheresis is highly dependent on operational parameters such as rotational speed and inlet flow rate. However, fixed-protocol systems limit multi-objective optimization and adaptability to donor variability. To investigate the coupled effects of rotational speed and …

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A Cohort Study of 38 Classic Wiskott-Aldrich Syndrome Cases with Six Novel Mutations

Anahita Razaghian, Mohsen Badalzadeh, Amir Ali Hamidieh, Raheleh Shokouhi Shoormasti et autres

PURPOSE: Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency characterized by eczema, microthrombocytopenia, and recurrent infections. This study evaluates the frequency of clinical manifestations and overall outcomes in WAS patients, comparing those who received hematopoietic stem cell transplantation (HSCT) with those who did …

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Combined PD-1 and CTLA-4 Blockade Enhances NK Cell-Mediated Cytotoxicity Against Primary Lymphoblasts in Acute Lymphoblastic Leukemia

Neda Parvini, Amir Ali Hamidieh, Fardin Fathi, Abbas Ali Amini et autres

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Efficacy and Safety of Pegfilgrastim in Patients With Severe Congenital Neutropenia

Mahdiyeh Movahedi, Leila Moradi, Zahra Alizadeh, Mojtaba Tabatabaei Yazdi et autres

Background: Severe congenital neutropenia (SCN) is commonly treated with granulocyte colony-stimulating factor (G-CSF) to reduce neutropenia and the associated risk of infections. Pegfilgrastim, a long-acting form of G-CSF, provides the benefit of less frequent dosing; however, its application in SCN has not …

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Hematopoietic stem cell transplantation in 746 children with osteopetrosis: A study of the inborn errors working party of the EBMT

Robert Chiesa, Michael H. Albert, Patrick Gilbert, Jeroen Knippenberg et autres

Abstract Introduction Osteopetrosis (OP) is a group of rare inherited conditions characterized by dysfunctional osteoclasts, leading to hypocalcemia, cytopenia, bone fractures, compression of cranial nerves and vision loss. Hematopoietic stem cell transplantation (HSCT) is the only curative approach for most children with …

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Cryopreservation as an Alternative Approach for Applying Photopheresis Products to Treat Graft‐Versus‐Host Disease ( GVHD ) Among Pediatric Patients in Developing Countries

Leila Jafari, Pooya Ashkevari, Sarina Ansari, Mona Delkhah et autres

BACKGROUND: A significant challenge in extracorporeal photopheresis (ECP) in developing countries is the high cost of apheresis equipment. Additionally, obtaining proper IV access in pediatric patients is considerably more difficult than in adult patients. To address the limitations of applying ECP for …

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Obstacles and facilitators of parents’ coping with hematopoietic stem cell transplantation of a child with cancer

Batool Pouraboli, Maryam Maleki, Nahid Dehghan Nayeri, Amir Ali Hamidieh et autres

BACKGROUND: Pediatric hematopoietic stem cell transplantation (HSCT) is a complex process that impacts the entire family. The traumatic nature of the pediatric HSCT period makes this a particularly vulnerable time for parents, leading to coping challenges. This study aimed to explore parents' …

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Autophagy and Reactive Oxygen Species in Megakaryopoiesis and Platelet Production

Abbas Khosravi, Abtin Ghasempour, Mostafa Paridar, Pargol Mashati et autres

Megakaryocytes (MKs), which are differentiated from megakaryocytic–erythrocytic progenitors, generate platelets (PLTs) by expanding and branching their cellular fragments under the influence of cytokines and intercellular mechanisms such as autophagy and release of reactive oxygen species (ROS) in the bone marrow. Autophagy is …

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