Hui Xu

Integrated Gut Microbiota–Drug Interaction Analysis and Network Pharmacology for the Investigation of Renal-Protective Effect of Polygala tenuifolia Willd

Jia-Chun Hu, Jian‐Ye Song, Ru Feng, Meng-Liang Ye et autres

Polygala tenuifolia Willd., a widely used traditional Chinese medicine, has the function of coordinating heart and kidney and eliminating swelling. However, its renal-protective efficacy and possible material basis remain unknown. The aim of the study was to investigate the renal-protective effect of …

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Gut Microbiota‐Derived Metabolites Orchestrate Metabolic Reprogramming in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Frontiers

Xinyu Yang, Ru Feng, Meng-Liang Ye, Hui Xu et autres

Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes mellitus, characterized by myocardial structural and functional abnormalities in the absence of overt coronary artery disease or hypertension. A growing body of evidence implicates the gut microbiota and its metabolites as key …

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Renal Health Through Medicine–Food Homology: A Comprehensive Review of Botanical Micronutrients and Their Mechanisms

Yi Zhao, Jian‐Ye Song, Ru Feng, Jia-Chun Hu et autres

BACKGROUND: As an ancient concept and practice, "food as medicine" or "medicine-food homology" is receiving more and more attention these days. It is a tradition in many regions to intake medicinal herbal food for potential health benefits to various organs and systems …

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The changes of intestinal microbiota and metabolomics during the inhibition of bladder cancer by liquiritigenin

Zhao Zhai, Jie Fu, Meng-Liang Ye, Jingyue Wang et autres

Liquiritigenin is a natural medicine. However, its inhibitory effect and its potential mechanism on bladder cancer (BCa) remain to be explored. It was found that it could be visualized that the transplanted tumours in the low-dose liquiritigenin -treated group and the high-dose …

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Gut microbiota-based metabolites of Xiaoyao Pills (a typical Traditional Chinese medicine) ameliorate depression by inhibiting fatty acid amide hydrolase levels in brain

Zhengwei Zhang, Pei Han, Jie Fu, Hang Yu et autres

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Combined treatment of budesonide and ursodeoxycholic acid for non-cirrhotic primary biliary cholangitis: a systematic review and meta-analysis

Kai Song, Chengzhen Lyu, Ziqi Guo, Xu Hong et autres

PI3K/AKT/mTOR Signaling Pathway Is Downregulated by Runzaoling (RZL) in Sjögren’s Syndrome

Ping Zeng, Zong Jiang, Zhaowei Huang, Ying Huang et autres

Infiltration and aggregation of lymphocytes in exocrine glands are the basic pathological manifestations of Sjögren's syndrome (SS), and the incidence of SS has been increasing year by year in recent years. To explore the potential signaling pathway of Runzaoling (RZL) in alleviating …

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Prognostic value of lncRNA HOXA‐AS3 in cervical cancer by targeting miR ‐29a‐3p and its regulatory effect on tumor progression

Hui Xu, Yan Tang, Chuanyong He, Yong Tian et autres

BACKGROUND: With the promotion of human papillomavirus (HPV) vaccine, cervical cancer has become a current research hotspot, and lncRNA has been confirmed to be used in the research of different diseases. This article systematically expounds the regulation and potential mechanisms of HOXA …

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Downregulation of lncRNA ASMTL-AS1 in Epithelial Ovarian Cancer Correlates with Worse Prognosis and Cancer Progression

Hui Xu, Yan Tang, Lu Liu, Jie Yan et autres

Given the characters of "Silent killer", epithelial ovarian cancer (EOC) usually suffered late diagnosis and poor prognosis. Therefore, this study aimed to explore the prognostic significance of ASMTL-AS1 in EOC and investigated the effect of lncRNA ASMTL-AS1 dysregulation on tumor cellular function. …

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Comprehensive analysis of survival related ceRNA regulatory net- work in Cholangiocarcinoma

Xiaoling Gao, Wenhao Zhang, Yanjuan Jia, Hui Xu et autres

Abstract Background: Cholangiocarcinoma (CCA) is a highly malignant disease with poor prognosis. Its occurrence and development mechanisms remain unearthed. The ceRNA network describes the relationship between cancer-related RNAs and reveals the potential regulatory mechanism in CCA pathogenesis. Method: The genome transcriptome dataset …

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The influence of known pathogenic gene mutation and ApoEε4 on neuropsychological evaluation and imaging markers in preclinical stage of familial Alzheimer’s disease

Meina Quan, Longfei Jia, Yi Tang, Qi Wang et autres

Abstract Background In the preclinical stage of familial Alzheimer's disease (FAD), there have been changes in multi‐dimensional indicators, such as pathology, neuropsychology and imaging. This study explored the effects of known pathogenic gene mutation and ApoE on neuropsychology and imaging markers before …

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Study on individualized prostate biopsy guided by prostate specific antigen at different ranges

Jinqi Song, Yanan Zhou, Gang-Liang Tu, Hui Xu et autres

Background: Prostate specific antigen (PSA) is the most commonly used indicator for screening of prostate cancer(PCa), and the studies on PSA in PCa are very extensive at present. How to effectively use this indicator is worth for further study which this article …

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