Ru Feng

Quercetin's antitumor effect in bladder cancer: Synergistic regulation of gut microbiota and l-serine metabolic pathway

Zhao Zhai, Feiya Yang, Ru Feng, Hao Zhang et autres

Quercetin is a bioflavonoid that is abundant and easy to extract, and has beneficial effects such as anti-cancer, anti-inflammatory, and antioxidant properties. We have demonstrated that oral administration of quercetin in an animal model inhibits bladder cancer (BCa), with inhibition rates of …

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Machine Learning-Based Prediction of Cell-type Resolved Brain eQTLs Enhances Discovery of Variants Explaining Alzheimer’s Disease Heritability

Chirag M. Lakhani, Giacomo Cavalca, Anjing Liu, Rohan Nidumbur et autres

Abstract The majority of causal genome-wide association studies (GWAS) variants for Alzheimer’s disease (AD) are believed to reside in noncoding regions of the genome, where they likely affect gene regulation, particularly in microglia. Although expression Quantitative Trait Loci (eQTL) studies offer valuable …

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Efficacy and prognostic determinants of BTK inhibitors in chronic lymphocytic leukemia (CLL): A real-world single-center cohort study from China

Xutao Guo, Yongqiang Wei, Xiaolei Wei, Qi Wei et autres

Abstract Background CLL is the most common adult leukemia in Western countries, with a rising incidence in China. Bruton's tyrosine kinase (BTK) inhibitors, such as ibrutinib and zanubrutinib, have revolutionized CLL treatment by improving progression-free survival (PFS) and overall survival (OS). However, …

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Risk factors and outcomes of carbapenem-resistant and multidrug-resistant klebsiella pneumoniae bloodstream infection in patients with acute leukemia

Youhai Yuan, Shanshan Zhang, Yongqiang Wei, Ru Feng et autres

Abstract Background: Klebsiella pneumoniae bloodstream infection (KP-BSI) is a severe and potentially fatal complication in patients with acute leukemia. The increasing prevalence of carbapenem-resistant (CR) and multidrug-resistant (MDR) strains presents significant therapeutic challenges and may worsen clinical outcomes. Methods: We retrospectively analyzed …

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Variable Loading Forecasting in the Service Areas of Highway Based on Llama3-8B of LLM

Ke Ji, Chengshuo Zhang, Yimai Zhang, Ru Feng

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mRNA m5C Alteration in Azacitidine Demethylation Treatment of Acute Myeloid Leukemia

Yue Leon Guo, Zaifeng Zhang, Chang Li, Lili Zhang et autres

The DNA demethylating therapy with azacitidine (AZA) is a promising therapeutic strategy for elderly patients with acute myeloid leukemia (AML). AZA primarily inhibits DNA methylation, promotes cell differentiation and apoptosis in AML. However, as a cytosine nucleoside analog, AZA also has the …

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Renal Health Through Medicine–Food Homology: A Comprehensive Review of Botanical Micronutrients and Their Mechanisms

Yi Zhao, Jian‐Ye Song, Ru Feng, Jia-Chun Hu et autres

BACKGROUND: As an ancient concept and practice, "food as medicine" or "medicine-food homology" is receiving more and more attention these days. It is a tradition in many regions to intake medicinal herbal food for potential health benefits to various organs and systems …

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Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice

Qingqing Qi, Zheyu Jin, Changchun Wang, Mengyu Xia et autres

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Comprehensive analysis of m 6 A methylome alterations after azacytidine plus venetoclax treatment for acute myeloid leukemia by nanopore sequencing

Zaifeng Zhang, Lili Zhang, Jiangtao Li, Ru Feng et autres

N6 adenosine methylation (m 6 A), one of the most prevalent internal modifications on mammalian RNAs, regulates RNA transcription, stabilization, and splicing. Growing evidence has focused on the functional role of m 6 A regulators on acute myeloid leukemia (AML). However, the …

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Simultaneous profiling of host expression and microbial abundance by spatial metatranscriptome sequencing

Lin Lyu, Xue Li, Ru Feng, Xin Zhou et autres

We developed an analysis pipeline that can extract microbial sequences from spatial transcriptomic (ST) data and assign taxonomic labels, generating a spatial microbial abundance matrix in addition to the default host expression matrix, enabling simultaneous analysis of host expression and microbial distribution. …

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Microbiota-stimulated Interleukin-22 regulates brain neurons and protects against stress-induced anxiety

Anoj Ilanges, Mengyu Xia, Junmei Lü, Lei Chen et autres

Summary Psychological stress and its sequelae are a major public health problem. While the immune system has been implicated in the development of stress-related disorders, how the immune signals modulate neural responses to stress is poorly understood. Contrary to our expectations, we …

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Simultaneous Profiling of Host Expression and Microbial Abundance by Spatial Meta-Transcriptome Sequencing

Lin Lyu, Xue Li, Ru Feng, Xin Zhou et autres

Abstract We developed an analysis pipeline that can extract microbial sequences from Spatial Transcriptomic (ST) data and assign taxonomic labels, generating a spatial microbial abundance matrix in addition to the default host expression matrix, enabling simultaneous analysis of host expression and microbial …

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