George S. Campbell

BPS2025 - Multiphase behavior of nucleolar components governs the spatial heterogeneity of the outer region of the nucleolus

Priyanka Dogra, Mylene C. Ferrolino, Suparna Khatun, Michele Tolbert et autres

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EPEN-22. ZFTA FUSION ONCOPROTEINS DRIVE ONCOGENESIS THROUGH ASSEMBLY OF BIOMOLECULAR CONDENSATES

Srinidhi Varadharajan, Amir Arabzade, Hazheen K. Shirnekhi, Siri Ippagunta et autres

Abstract BACKGROUND Ependymomas continue to be an aggressive brain tumor entity without targeted therapies. The highly recurrent fusion oncoprotein (FO), ZFTA-RELA, is known to be associated with about 70% of supratentorial ependymomas. While recent studies have highlighted that the fusion protein is …

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Serotonin Stimulates Protein Tyrosyl Phosphorylation and Vascular Contraction via Tyrosine Kinase

Stephanie W. Watts, Cheol Ho Yeum, George S. Campbell, Clinton Webb

Serotonin (5-HT, 5-hydroxytryptamine) is a mitogen in vascular smooth muscle and vascular reactivity to 5-HT is significantly enhanced in hypertension and atherosclerosis. We have tested the hypothesis that tyrosine kinases, enzymes important for mitogenesis, may play a role in 5-HT-induced vascular smooth …

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Gene regulation by nutritional and endocrine stress: investigation using a human placenta-specific expression array

Helen Jones, George S. Campbell, H. J. McArdle

Regulation of Glucose Transport and c-fos and egr-1 Expression in Cells with Mutated or Endogenous Growth Hormone Receptors*

Tzy-Wen L. Gong, Debra J. Meyer, Jinfang Liao, Christina L. Hodge et autres

To identify mechanisms by which GH receptors (GHR) mediate downstream events representative of growth and metabolic responses to GH, stimulation by GH of c-fos and egr-1 expression and glucose transport activity were examined in Chinese hamster ovary (CHO) cells expressing mutated GHR. …

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Growth-hormone signal transduction

George S. Campbell

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Constitutive Activation of JAK1 in Src-transformed Cells

George S. Campbell, Chao‐Lan Yu, Richard Jove, Christin Carter‐Su

We have previously found that the signal transducer and activator of transcription (Stat) 3 is constitutively activated in cells stably transformed by the v-Src oncoprotein. While activation of Stat proteins has also been observed following epidermal growth factor or platelet-derived growth factor …

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Molecular Mechanisms of Growth Hormone Action

Christin Carter‐Su, Anthony P. King, Lisa S. Smit, Joyce A. VanderKuur et autres

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Signalling Pathway of GH.

Christin Carter‐Su, Anthony P. King, Lawrence S. Argetsinger, Lisa S. Smit et autres

GH has long been known as a regulator of body growth and metabolism, yet its mechanism of action at the cellular level has been elusive. We have recently shown that GH promotes the rapid association of GH receptor with the tyrosine kinase …

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Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

Chao‐Lan Yu, Debra J. Meyer, George S. Campbell, Andrew C. Larner et autres

Cytokines and growth factors induce tyrosine phosphorylation of signal transducers and activators of transcription (STATs) that directly activate gene expression. Cells stably transformed by the Src oncogene tyrosine kinase were examined for STAT protein activation. Assays of electrophoretic mobility, DNA-binding specificity, and …

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Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone

George S. Campbell, Debra J. Meyer, Regina Raz, David E. Levy et autres

The mechanism by which the binding of growth hormone (GH) to its cell surface receptor elicits changes in gene transcription are largely unknown. The transcription factor Stat1/p91 has been shown to be activated by GH. Here we show that acute phase response …

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Evidence for a regulatory element controlling amino aced transport system L in Chinese hamster ovary cells

Ellen J. Collarini, George S. Campbell, Dale L. Oxender

We have used the technique of somatic cell hybridization to study the regulation of the neutral amino acid transport system L in Chinese hamster ovary (CHO) cells. The cell line CHO-ts025C1 has a temperature-sensitive mutation in leucyl-tRNA synthetase. At the nonpermissive temperature …

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