Accès ouvert
2026
article
OpenAlex
Siri Ippagunta, Amir Arabzade, Srinidhi Varadharajan, Erik Emanus et autres
BACKGROUND: Ependymoma (EPN) is the third most common pediatric brain tumor with no targeted therapies available to patients. In supratentorial ependymoma, the most frequent driver alteration is a gene fusion between ZFTA and RELA (denoted ZR), leads to constitutive localization of ZR …
us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Alisha Kardian, Hua Sun, Siri Ippagunta, Nicholas Laboe et autres
ZFTA–RELA is the most recurrent genetic alteration seen in paediatric supratentorial ependymoma (EPN) and is sufficient to initiate tumours in mice1. Despite its oncogenic potential, ZFTA–RELA (ZR) is observed nearly exclusively in childhood EPN, with tumours located distinctly in the supratentorial brain …
us, gb
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Blake Holcomb, Ha Won Lee, Pete Hall, Shilpa Narina et autres
Abstract Treatments for childhood brain cancer, the leading cause of disease mortality in children, has not changed in the last three decades and constitutes surgery combined with cytotoxic chemo- and radio- therapy. RT is not always curative, and the mechanisms that promote …
us
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Sanya Mehta, Siri Ippagunta, Alisha Kardian, Srinidhi Varadharajan et autres
Abstract Targeted treatments are desperately needed for ependymomas (EPN). Chimeric antigen receptor (CAR) T-cells have the potential to transform patient outcomes. However, little is known regarding the antitumor efficacy of CAR T-cells against EPNs. We found that B7-H3 is highly and consistently …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Siri Ippagunta, Amir Arabzade, Srinidhi Varadharajan, Erik Emanus et autres
Abstract Ependymoma (EPN) is the third most common pediatric brain tumor with no targeted therapies available to patients. The most frequent driver alteration is a gene fusion between ZFTA and RELA (denoted ZR), which leads to constitutive localization of ZR in the …
us
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Amir Arabzade, Hazheen K. Shirnekhi, Srinidhi Varadharajan, Siri Ippagunta et autres
Abstract Over 95% of ependymomas (EPN) that arise in the cortex are characterized by gene fusions commonly involving the zinc finger translocation associated (ZFTA) protein. These fusion oncoproteins (FOs) join ZFTA with either a transcription factor or co-activator, leading to a chimeric …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Hua Sun, Alisha Kardian, Siri Ippagunta, Nicholas Laboe et autres
Abstract Pediatric cancers are often driven by unique alterations suggesting mechanistic ties to underlying developmental programs. Ependymoma (EPN) is an example of a brain cancer subtype driven by gene fusions involving ZFTA-RELA (ZR) that are exclusive to this disease. This leads to …
us
(code pays fourni par la source)
Accès ouvert
2025
other
OpenAlex
Sanya Mehta, Siri Ippagunta, Srinidhi Varadharajan, Alisha Kardian et autres
Supplementary Tables S1 and S2
Accès ouvert
2025
other
OpenAlex
Sanya Mehta, Siri Ippagunta, Srinidhi Varadharajan, Alisha Kardian et autres
Figure S9 shows Type 2 polarization of B7-H3.CAR T-cells over repetitive stimulation with EPN cells.
Accès ouvert
2025
other
OpenAlex
Sanya Mehta, Siri Ippagunta, Srinidhi Varadharajan, Alisha Kardian et autres
Figure S17 shows effective control of PFA EPN xenografts by B7-H3.CAR T-cells in vivo.
Accès ouvert
2025
other
OpenAlex
Sanya Mehta, Siri Ippagunta, Srinidhi Varadharajan, Alisha Kardian et autres
Figure S1 shows representative B7-H3 staining intensity scale.
Accès ouvert
2025
other
OpenAlex
Sanya Mehta, Siri Ippagunta, Srinidhi Varadharajan, Alisha Kardian et autres
Figure S6 shows B7-H3.CAR T-cell expansion vs EPN cell target antigen density.