Regina Raz

PPMO's as Therapeutic Modulators for Myotonic Dystrophy Type 1

Ashling Holland, Miguel A. Varela, Arnaud F. Klein, Regina Raz et autres

BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells via Interaction with Acvr2b

Shoichiro Kokabu, Laura W. Gamer, Karen A. Cox, Jonathan Wayne Lowery et autres

Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted disruption of BMP3 in mice results in …

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The mutationROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome

Regina Raz, Sigmar Stricker, Elizabetta Gazzerro, Julie L. Clor et autres

Mutations in ROR2 result in a spectrum of genetic disorders in humans that are classified, depending on the nature of the mutation and the clinical phenotype, as either autosomal dominant brachydactyly type B (BDB, MIM 113000) or recessive Robinow syndrome (RRS, MIM …

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Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

Roberto Chiarle, William J. Simmons, Honjying Cai, Girish Dhall et autres

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STAT3 is Not Essential for Mouse Lens Development

SJ Ebong, A.B. Chepelinsky, ML Robinson, Regina Raz et autres

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Deletion of Stat3 Blocks Mammary Gland Involution and Extends Functional Competence of the Secretory Epithelium in the Absence of Lactogenic Stimuli

Robin C. Humphreys, Brian Bierie, Ling Zhao, Regina Raz et autres

The transcription factor Stat3 is activated through tyrosine phosphorylation by many cytokines and is a fundamental mediator of their signals. In the mammary gland, Stat3 activity increases sharply shortly after weaning, and involution is delayed in mice, that contain a mutant Stat3 …

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STAT3 Is a Negative Regulator of Granulopoiesis but Is Not Required for G-CSF-Dependent Differentiation

Chien‐Kuo Lee, Regina Raz, Ramón Gimeno, Rachel Gertner et autres

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STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2

Malika Sahni, Regina Raz, J. Douglas Coffin, David E. Levy et autres

Unregulated FGF receptor signaling results in bone malformations that affect both endochondral and intramembranous ossification, and is the basis for several genetic forms of human dwarfism. FGF signaling inhibits chondrocyte proliferation and we have previously shown that the transcription factor STAT1 mediates …

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Cooperation between STAT3 and c-Jun Suppresses Fas Transcription

Vladimir N. Ivanov, Anindita Bhoumik, Krasil'nikov Ma, Regina Raz et autres

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Stat3 and Ras activation are required for the cellular transformation mediated by NPM-ALK.

Roberto Chiarle, Ilaria Guasparri, Alberto Zamò, Regina Raz et autres

Essential role of STAT3 for embryonic stem cell pluripotency

Regina Raz, Chien‐Kuo Lee, Linda A. Cannizzaro, Peter D’Eustachio et autres

Propagation of mouse embryonic stem (ES) cells in vitro requires exogenous leukemia inhibitory factor (LIF) or related cytokines. Potential downstream effectors of the LIF signal in ES cells include kinases of the Src, Jak, and mitogen-activated protein families and the signal transducer …

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The Proximal Tyrosines of the Cytoplasmic Domain of the β Chain of the Type I Interferon Receptor Are Essential for Signal Transducer and Activator of Transcription (Stat) 2 Activation

Owen W. Nadeau, Paul J. Domanski, Anna Usacheva, Shahab Uddin et autres

The precise role of the different subunits (alpha/IFNAR1 and betaL/IFNAR2) of the type I interferon receptor (IFN-R) in the activation of signal transducer and activator of transcription (Stat) 1, Stat2, and Stat3 has not yet been established. In this report we demonstrate …

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