Yves Mély

[Corrigendum] TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex

Tanveer Ahmad, Waseem Ashraf, Abdulkhaleg Ibrahim, Liliyana Zaayter et autres

for granting them the opportunity to publish this corrigendum, and all the authors agree with its publication. [International Journal of Oncology 59: 89, 2021; DOI: 10.3892/ijo.2021.5269].

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Sorting of lysosomal enzyme and autophagy are regulated by the GGA1-induced TGN lipid scrambling

Kohta Takahashi, Nario Tomishige, Mitsuhiro Abe, Gašper Šolinc et autres

The physiological role of lipid asymmetry in intracellular membranes remains poorly understood. Here, we show that sphingomyelin (SM), typically confined to the lumen of the trans-Golgi network (TGN), is exposed on its cytoplasmic surface by the action of the Golgi-associated protein, Golgi-associated …

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[Expression of Concern] TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex

Tanveer Ahmad, Waseem Ashraf, Abdulkhaleg Ibrahim, Liliyana Zaayter et autres

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the GAPDH control western blots shown in Fig. 5A on p. 9 for the experiments without MG132 treatment ('‑ MMGM132') were strikingly similar to …

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Selection of Host Plasma Membrane Lipids by HIV‐1 Gag Protein

Nario Tomishige, Yves Mély, Toshihide Kobayashi

ABSTRACT Human immunodeficiency virus type 1 (HIV‐1) possesses an envelope enriched with a specific set of host plasma membrane (PM) lipids, a composition that is critical for viral infectivity. Virus budding is initiated by the binding of the viral Gag protein to …

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Using Dark Dyes for Fast Super-Resolution Imaging: A Proof-of-Concept Study

Srijayee Ghosh, Guillaume Barnoin, Benoît Y. Michel, Alain Burger et autres

DNA-PAINT (Point Accumulation for Imaging in Nanoscale Topography) exploits the transient hybridization of a short fluorescent DNA imager strand to a complementary docking strand to achieve super-resolution imaging. However, its application is hampered by the background noise caused by unbound imager strands …

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Directed-complement killing of Pseudomonas aeruginosa protects against lethal pneumonia

Aubin Pitiot, Bianca Brandus, Gilles Iserentant, Camille Rolin et autres

BACKGROUND: Multidrug-resistant Pseudomonas aeruginosa raises major clinical concerns due to its capacity to cause a wide-array of infections in individuals with compromised immune defences and to withstand standard-of-care therapeutic treatments. Antibody-based approaches have proven to be efficient in the treatment of diverse …

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Decoding the base flipping mechanism of the SET- and RING-associated (SRA) domain of the epigenetic UHRF1 protein

Dipanjan Mukherjee, Stefano Ciaco, Lara Martínez‐Fernández, Krishna Gavvala et autres

Ubiquitin-like, containing PHD and RING fingers domains 1 (UHRF1) plays a pivotal role in replicating DNA methylation patterns during cell division. Acting as a DNA reader, UHRF1, via its SET- and RING-associated (SRA) domain, recognizes hemi-methylated (HM) CpG sites and flips 5-methylcytosine …

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The Bacterium P. aeruginosa Disperses Ordered Membrane Domains by Targeting Phase Boundaries

Kai Stober, Fabian Schwerdtfeger, Sahaja Aigal, Yves Mély et autres

Various pathogens use receptors on the host’s plasma membrane for their cellular uptake. For the bacterium Pseudomonas aeruginosa, interactions between its lectin LecA and the host cell glycosphingolipid globotriaosylceramide (also known as Gb3) are crucial for its internalization via the so-called lipid …

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Exploring excited-state proton transfer reactions in isothiazologuanosine, an isofunctional fluorescent analogue of guanosine

Olha Tkach, Lara Martínez‐Fernández, Atzin Esmeralda Ruiz-Lera, Nicolas Humbert et autres

Due to its complex photophysics, isothiazologuanosine ( tz G), an isomorphic and isofunctional fluorescent analogue of guanosine, is highly responsive over a wide range of acidic (0–5) and basic pH values (8–10).

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Impact of surface chemistry of upconversion nanoparticles on time-dependent cytotoxicity in non-cancerous epithelial cells

Susanne Märkl, Frédéric Przybilla, Reinhard Rachel, Thomas Hirsch et autres

Abstract The application of upconversion nanoparticles (UCNPs) for cell and tissue analysis requires a comprehensive understanding of their interactions with biological entities to prevent toxicity or harmful effects. Whereas most studies focus on cancer cells, this work addresses non-cancerous cells with their …

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Editorial: MAF journal and conference build together

David J. S. Birch, Marcia Levitus, Yves Mély

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Structure and activity of the Lugdulysin M30 zinc metallopeptidase, a potential virulence factor from Staphylococcus lugdunensis

Marc Ruff, Nicolas Lévy, Kévin Prola, Nicolas Humbert et autres

Abstract Staphylococcus lugdunensis, a skin commensal, secretes metallopeptidase Lugdulysin associated with bone-joint infections. We structurally and functionally characterize Lugdulysin. Crystallographic structures of the native protein and of an inactive double mutant reveal the intramolecular chaperone role of the N-term 22 residues of …

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