Sharon Edwards

A Case of Pembrolizumab‐Induced Pityriasis Lichenoides‐Like Eruption Treated Successfully With Dupilumab

Evangelos Christou, Sharon Edwards, Andrew Affleck

ABSTRACT Immune‐checkpoint inhibitors (ICIs) have revolutionised melanoma treatment but can often cause severe and long‐standing cutaneous immune‐related adverse events (cirAEs). We report a case of refractory pembrolizumab‐induced pityriasis lichenoides (PL)‐like eruption successfully treated with dupilumab, leading to rapid and sustained remission. This …

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Tools for Effective Nursing in the Care of the Infertile Patient

Sharon Edwards

Reproductive Endocrinology and Infertility (REI) or Assisted Reproductive Technology (ART) nursing is a relatively new field that began in the 1970s with hospital-based infertility clinics where nurses were considered the doctor&s;s “assistant.” The field has expanded considerably from those days into a …

Planned dose reduction of ocrelizumab in relapsing-remitting multiple sclerosis: a single-centre observational study

Trung Dang Quoc Tran, Leanne Hall, Clare Heal, Nagaraja Haleagrahara et autres

Background Ocrelizumab, a humanised anti-CD20 monoclonal, is a highly effective treatment for relapsing-remitting multiple sclerosis (RRMS). The long-term safety of B-cell depletion in RRMS, however, is uncertain and there are no data on dose reduction of ocrelizumab as a risk mitigation strategy. …

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Neuro-Sweet syndrome

Krishna Thazhatheyil, Marese O’Reilly, Nikolas Rae, Sharon Edwards et autres

Neuro-Sweet syndrome is rare and presents as an acute febrile neutrophilic dermatosis accompanied by neurological symptoms. We describe a patient with neuro-Sweet syndrome whose diagnosis was confirmed via skin biopsy. Treatment with steroids achieved clinical resolution of the patient’s symptoms and signs.

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PET-CT for staging pT4b melanomas prior to sentinel lymph node biopsy: a 5-year review

Claire Hardie, Ammar Allouni, Sharon Edwards, Najeeb Ahmed et autres

In this centre, patients with pT4b cutaneous melanoma are staged using 18F-FDG PET-computed tomography (PET-CT) prior to considering sentinel lymph node biopsy (SLNB). The objective was to assess the utility of PET-CT in terms of rates of detection of metastases leading to …

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A darkly pigmented verrucous papule on the nape of neck

Angela Alani, Sharon Edwards, Andrew Affleck

Click here for the corresponding questions to this CME article.

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197 Functional assessment of the atopic eczema candidate gene EMSY identifies a role in skin barrier formation

Martina S. Elias, S. Wright, Judit Reményi, James Abbott et autres

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Reducing drug errors by engaging student nurses in medication management simulation

Sharon Edwards, Joyce Williams, Mandy Lee

The occurrence of drug errors in the NHS has been much discussed in the media. Nurses are in a position to prevent drug errors, as they are often involved in administering medication or advising patients. To enable nurses to do this they …

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EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Martina S. Elias, S. Wright, Judit Reményi, James Abbott et autres

BACKGROUND: Atopic dermatitis (AD) is a common, complex, and highly heritable inflammatory skin disease. Genome-wide association studies offer opportunities to identify molecular targets for drug development. A risk locus on chromosome 11q13.5 lies between 2 candidate genes, EMSY and LRRC32 (leucine-rich repeat-containing …

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Student-led simulation: preparing students for leadership

Sharon Edwards, Mandy Lee, Kelly Sluman

It is vital to prepare nurses to become informed leaders with the required knowledge and skills to support effective patient care and outcomes. This article describes an innovative teaching method that enables students to create simulation scenarios based on their clinical experiences, …

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Results of cross-faculty ‘capstone’ assessments involving nursing and performing arts students

Sharon Edwards, Nic Fryer, Michelle Boot, Michael Farquharson et autres

This article describes how 'capstone' assessments were created to provide two different student groups, nursing and performing arts students, with a lived experience of learning together about their own fields of practice. Capstone assessments combine 'live' human simulation with self-reflection and peer …

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Medication management: Reducing drug errors, striving for safer practice

Sharon Edwards, Sue Axe

The issue of drug errors in the NHS has been highlighted recently in the mainstream press, and has shown that mistakes can, and occasionally do, happen. Yet nurses are in a unique position to prevent drug errors, as they are at the …

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