Richard H.C. Huntwork

A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein

Anaïs Gambiez, Mary Osei-Twum, The CoVIC-DB Team, Paul Kellam et autres

us (code pays fourni par la source)

A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein

Sharon L. Schendel, Xiaoying Yu, Peter Halfmann, Jarjapu Mahita et autres

The Coronavirus Immunotherapeutic Consortium (CoVIC) conducted side-by-side comparisons of over 400 anti-SARS-CoV-2 spike therapeutic antibody candidates contributed by large and small companies as well as academic groups on multiple continents. Nine reference labs analyzed antibody features, including in vivo protection in a …

us, gb, jp (code pays fourni par la source)

Cryptic-site-specific antibodies to the SARS-CoV-2 receptor binding domain can retain functional binding affinity to spike variants

Georgia D. Tomaras, Elizabeth Feeney, Eduardo Olmedillas, S. Munir Alam et autres

IMPORTANCE: Multiple SARS-CoV-2 variants of concern have emerged and caused a significant number of infections and deaths worldwide. These variants of concern contain mutations that might significantly affect antigen-targeting by antibodies. It is therefore important to further understand how antibody binding and …

us (code pays fourni par la source)

Peer Review Report For: TitrationAnalysis: a tool for high throughput binding kinetics data analysis for multiple label-free platforms [version 2; peer review: 6 approved]

Kan Li, Richard H.C. Huntwork, Gillian Q. Horn, S. Munir Alam et autres

Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics data of bimolecular interactions. To efficiently analyze SPR and BLI binding kinetics data, we have built a new high throughput analysis tool …

us (code pays fourni par la source)

Peer Review Report For: TitrationAnalysis: a tool for high throughput binding kinetics data analysis for multiple label-free platforms [version 2; peer review: 6 approved]

Kan Li, Richard H.C. Huntwork, Gillian Q. Horn, S. Munir Alam et autres

Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics data of bimolecular interactions. To efficiently analyze SPR and BLI binding kinetics data, we have built a new high throughput analysis tool …

us (code pays fourni par la source)

Peer Review Report For: TitrationAnalysis: a tool for high throughput binding kinetics data analysis for multiple label-free platforms [version 2; peer review: 6 approved]

Kan Li, Richard H.C. Huntwork, Gillian Q. Horn, S. Munir Alam et autres

Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics data of bimolecular interactions. To efficiently analyze SPR and BLI binding kinetics data, we have built a new high throughput analysis tool …

us (code pays fourni par la source)

Somatic hypermutation-mediated paratope flexibility improves the cross-reactivity of human malaria antibodies

Rajagopal Murugan, Anton Hanke, Opeyemi Ernest Oludada, Giulia Costa et autres

ABSTRACT The protective capacity of antibodies targeting circumsporozoite protein on sporozoites of the malaria parasite Plasmodium falciparum (PfCSP) is linked to high affinity and cross-reactivity with the PfCSP central repeat domain and N-terminal junction. However, the role of somatic hypermutation (SHM) in …

de, nl, ch, us (code pays fourni par la source)

TitrationAnalysis: a tool for high throughput binding kinetics data analysis for multiple label-free platforms

Kan Li, Richard H.C. Huntwork, Gillian Q. Horn, S. Munir Alam et autres

Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics data of bimolecular interactions. To efficiently analyze SPR and BLI binding kinetics data, we have built a new high throughput analysis tool …

us (code pays fourni par la source)

A tool for analyzing complex epitope binning data of monoclonal antibodies

Kan Li, Richard H.C. Huntwork, Lynn Lin, Cliburn Chan et autres

us (code pays fourni par la source)

Cryptic-site-specific antibodies to the SARS-CoV-2 receptor binding domain can retain functional binding affinity to spike variants

Kan Li, Richard H.C. Huntwork, Gillian Q. Horn, Milite Abraha et autres

ABSTRACT The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has accumulated more than 700 million infection cases and 6.9 million deaths. New variants have affected antibody interaction with the surface spike protein. We defined the domain specificities and measured hexa-proline stabilized spike …

us, kr (code pays fourni par la source)

Peer Review Report For: TitrationAnalysis: a tool for high throughput binding kinetics data analysis for multiple label-free platforms [version 1; peer review: 3 approved]

Kan Li, Richard H.C. Huntwork, Gillian Q. Horn, S. Munir Alam et autres

Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics data of bimolecular interactions. To efficiently analyze SPR and BLI binding kinetics data, we have built a new high throughput analysis tool …

us (code pays fourni par la source)

Peer Review Report For: TitrationAnalysis: a tool for high throughput binding kinetics data analysis for multiple label-free platforms [version 1; peer review: 3 approved]

Kan Li, Richard H.C. Huntwork, Gillian Q. Horn, S. Munir Alam et autres

Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics data of bimolecular interactions. To efficiently analyze SPR and BLI binding kinetics data, we have built a new high throughput analysis tool …

us (code pays fourni par la source)