Larry Riggen

Change in Head Impact Exposure following Return to Sport in Concussed Football Athletes

Grant P. Sinson, Breanna Glaeser, Alok Suresh Shah, Steven Rowson et autres

PURPOSE: Following sport-related concussions, early head impact exposure and premature return to sport are known to increase the risk of repeat concussion in football athletes, yet athletes' true post-injury head impact exposure profiles (i.e., characteristics of recorded head impacts over a given …

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Subject-specific analysis approach to longitudinal tracing of heterogeneous white matter abnormalities in sports-related concussion

Ho‐Ching Yang, Mario Džemidžić, Qiuting Wen, Larry Riggen et autres

Motivation: Unlike groupwise approaches, subject-specific analysis has the potential to pinpoint highly individualized abnormalities in white matter structure caused by sport-related concussion (SRC). Goal(s): Develop a subject-specific analysis approach to investigate the heterogeneity and longitudinal changes in white matter microstructures after SRC. …

Subject-specific analysis reveals spatially heterogeneous white matter abnormalities in sports-related concussion

Ho‐Ching Yang, Mario Džemidžić, Qiuting Wen, Larry Riggen et autres

Sport-related concussion (SRC) injury inclines to cause subject-specific brain region abnormalities. This study applied subject-specific analysis that accounts for inter-subject variation to investigate heterogeneity of white matter alterations in a sample from a large national multicenter study, the Concussion Assessment, Research and …

7.14 Do head injury biomechanics predict injury recovery?

Jason P. Mihalik, Avinash S. Chandran, Jacob R. Powell, Patricia R. Roby et autres

Objective To test whether higher head injury biomechanics are associated with symptom resolution time (SRT) and return-to-participation time (RTP). Design Retrospective cohort study. Setting Six United States NCAA Division 1 colleges. Participants We studied 51 college American football players who sustained an …

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Gene Expression Alterations in Peripheral Blood Following Sport-Related Concussion in a Prospective Cohort of Collegiate Athletes: A Concussion Assessment, Research and Education (CARE) Consortium Study

Edward R. Simpson, Jill L. Reiter, Jie Ren, Zhiqi Zhang et autres

BACKGROUND: Molecular-based approaches to understanding concussion pathophysiology provide complex biological information that can advance concussion research and identify potential diagnostic and/or prognostic biomarkers of injury. OBJECTIVE: The aim of this study was to identify gene expression changes in peripheral blood that are …

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Longitudinal associations between blood biomarkers and white-matter MRI in sport-related concussion: A study of the NCAA-DoD CARE Consortium

Yu‐Chien Wu, Qiuting Wen, Jessica Gill, Rhea Thukral et autres

White matter structural changes occur when an athlete experiences a concussion. To determine if serum biomarkers are a good concussion diagnosis, it seems prudent to associate white matter structural changes to longitudinal biomarker samples. Longitudinal blood biomarkers and DTI scanning from 77 …

Longitudinal Associations Between Blood Biomarkers and White Matter MRI in Sport-Related Concussion

Yu‐Chien Wu, Qiuting Wen, Rhea Thukral, Ho‐Ching Yang et autres

Objective To study longitudinal associations between blood-based neural biomarkers (including total tau, neurofilament light (NfL), glial fibrillary acidic protein (GFAP), and ubiquitin C-terminal hydrolase-L1 (UCH-L1)) and white-matter neuroimaging biomarkers in collegiate athletes with sport-related concussion (SRC) from 24-hours post-injury to 1 week …

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Time Delta Head Impact Frequency: An Analysis on Head Impact Exposure in the Lead Up to a Concussion: Findings from the NCAA-DOD Care Consortium

Jack Seifert, Alok Suresh Shah, Jaroslaw Harezlak, Steven Rowson et autres

Sport-related concussions can result from a single high magnitude impact that generates concussive symptoms, repeated subconcussive head impacts aggregating to generate concussive symptoms, or a combined effect from the two mechanisms. The array of symptoms produced by these mechanisms may be clinically …

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Change in Head Impact Exposure following Return to Play in Concussed Football Athletes

Jared R. Muench, Grant P. Sinson, Jaroslaw Harezlak, Steven Rowson et autres

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Gene Expression Alterations in Peripheral Blood Following Sport-Related Concussion in a Prospective Cohort of Collegiate Athletes: A Concussion Assessment, Research and Education (CARE) Consortium Study

Yunlong Liu, Edward S. Simpson, Kelly Nicole Holohan Nudelman, Larry Riggen et autres

Abstract Rapid diagnosis of concussion is essential to effective treatment and recovery. Concussion biomarker research has focused primarily on blood-based protein assays to detect markers of brain injury. However, transcriptomic data provides insight into the complex biological response to concussion. In this …

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Similar Concussion Rates in Spring Football and Preseason: Findings From the Concussion Assessment, Research and Education Consortium

Steven P. Broglio, Susan M. Perkins, Larry Riggen, Brian D. Stemper et autres

CONTEXT: Increasing attention has been directed toward identifying aspects of football participation for targeted policy change that reduces the concussion risk. Prior researchers evaluated concussion risks during the preseason and regular seasons, leaving the spring season largely unexplored. DESIGN: In this nationally …

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Association between Preseason/Regular Season Head Impact Exposure and Concussion Incidence in NCAA Football

Brian D. Stemper, Jaroslaw Harezlak, Alok Suresh Shah, Steven Rowson et autres

PURPOSE: Contact sport athletes are exposed to a unique environment where they sustain repeated head impacts throughout the season and can sustain hundreds of head impacts over a few months. Accordingly, recent studies outlined the role that head impact exposure (HIE) has …

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