Gene Expression Alterations in Peripheral Blood Following Sport-Related Concussion in a Prospective Cohort of Collegiate Athletes: A Concussion Assessment, Research and Education (CARE) Consortium Study
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Le résumé fourni par la source
BACKGROUND: Molecular-based approaches to understanding concussion pathophysiology provide complex biological information that can advance concussion research and identify potential diagnostic and/or prognostic biomarkers of injury. OBJECTIVE: The aim of this study was to identify gene expression changes in peripheral blood that are initiated following concussion and are relevant to concussion response and recovery. METHODS: We analyzed whole blood transcriptomes in a large cohort of concussed and control collegiate athletes who were participating in the multicenter prospective cohort Concussion Assessment, Research, and Education (CARE) Consortium study. Blood samples were collected from collegiate athletes at preseason (baseline), within 6 h of concussion injury, and at four additional prescribed time points spanning 24 h to 6 months post-injury. RNA sequencing was performed on samples from 230 concussed, 130 contact control, and 102 non-contact control athletes. Differential gene expression and deconvolution analysis were performed at each time point relative to baseline. RESULTS: Cytokine and immune response signaling pathways were activated immediately after concussion, but at later time points these pathways appeared to be suppressed relative to the contact control group. We also found that the proportion of neutrophils increased and natural killer cells decreased in the blood following concussion. CONCLUSIONS: Transcriptome signatures in the blood reflect the known pathophysiology of concussion and may be useful for defining the immediate biological response and the time course for recovery. In addition, the identified immune response pathways and changes in immune cell type proportions following a concussion may inform future treatment strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Gene Expression Alterations in Peripheral Blood Following Sport-Related Concussion in a Prospective Cohort of Collegiate Athletes: A Concussion Assessment, Research and Education (CARE) Consortium Study
- Date Crossref
- 08/11/2023
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Indiana University School of Medicine Center for Medical Genomics pays non établi dans la noticeUniversité ou école supérieure
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Indiana University – Purdue University Indianapolis pays non établi dans la noticeUniversité ou école supérieure
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Indiana University Bloomington pays non établi dans la noticeUniversité ou école supérieure
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University of Wisconsin–Madison Department of Orthopedics pays non établi dans la noticeUniversité ou école supérieure
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Uniformed Services University of the Health Sciences Department of Physical Medicine and Rehabilitation pays non établi dans la noticeUniversité ou école supérieure
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Keller Army Community Hospital Department of Orthopaedic Surgery pays non établi dans la noticeÉtablissement de santé
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Virginia Tech pays non établi dans la noticeUniversité ou école supérieure
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United States Air Force Academy pays non établi dans la noticeOrganisme public
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University of Michigan Michigan Concussion Center pays non établi dans la noticeUniversité ou école supérieure
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Medical College of Wisconsin pays non établi dans la noticeUniversité ou école supérieure
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Walter Reed Army Institute of Research pays non établi dans la noticeOrganisme public
Center for Medical Genomics — Indiana University School of Medicine, Indiana University – Purdue University Indianapolis et Indiana University Bloomington, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.