Accès ouvert
2026
article
OpenAlex
Cuiling Xu, Haritha Annapureddy, Lilly Carson, Vansh Khurana et autres
Antiretroviral therapy (ART) has prolonged the life expectancy of persons living with HIV, the majority of whom are now older than 50 years. Aging people with HIV are at increased risk for cardiovascular events driven by HIV-related inflammation and hypercoagulation. Apixaban is …
us
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Accès ouvert
2025
article
OpenAlex
Anna J. Jasinska, Ranjit Sivanandham, Sindhuja Sivanandham, Cuiling Xu et autres
HIV infection accelerates biological aging, but the contribution of the host's age to this process is unknown. We investigated the influence of SIV infection in macaques (SIVmac) on the risk of comorbidities and aging in young and old rhesus macaques (RMs) by …
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Accès ouvert
2025
article
OpenAlex
Rodica Radu, Matthew J. Feinstein, Cristian Apetrei, Ivona Pandrea
With the advent of antiretroviral therapy (ART) that effectively suppresses HIV replication, and reduced AIDS progression, the clinical spectrum of HIV infection has dramatically changed. Currently, the people living with HIV (PLWH) who receive ART have a nearly normal prognostic of survival, …
us, ro
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Accès ouvert
2025
article
OpenAlex
Sindhuja Sivanandham, Ranjit Sivanandham, Cuiling Xu, Jen Symmonds et autres
Introduction: Lipid profiles change in human immunodeficiency virus (HIV) infection and correlate with inflammation. Lipidomic alterations are impacted by multiple non-HIV-related behavioral risk factors; thus, use of animal models in which these behavioral factors are controlled may inform on the specific lipid …
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Accès ouvert
2025
article
OpenAlex
Kevin D. Raehtz, Ivona Pandrea, Cristian Apetrei
PURPOSE OF REVIEW: Typically, both HIV-infected humans and simian immunodeficiency virus (SIV)-infected Asian nonhuman primates (NHPs) eventually progress to AIDS, while African NHPs that are natural hosts of SIV do not, in spite of life-long, high levels of viral replication. Lack of …
gb, us
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Accès ouvert
2024
article
OpenAlex
Kevin D. Raehtz, Cuiling Xu, Claire Deléage, Dongzhu Ma et autres
African green monkeys (AGMs) are natural hosts of SIV whose infection does not progress to AIDS. Since early events of infection may be critical to pathogenesis in nonnatural hosts, we investigated early SIV infection in 29 adult male AGMs intrarectally inoculated with …
us, it
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Accès ouvert
2024
article
OpenAlex
Jen Symmonds, Thaidra Gaufin, Cuiling Xu, Kevin D. Raehtz et autres
Understanding the underlying mechanisms of HIV pathogenesis is critical for designing successful HIV vaccines and cure strategies. However, achieving this goal is complicated by the virus's direct interactions with immune cells, the induction of persistent reservoirs in the immune system cells, and …
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Accès ouvert
2024
article
OpenAlex
Shalini Singh, Leila B. Giron, Maliha Shaikh, Shivanjali Shankaran et autres
BACKGROUND: People living with HIV (PLWH), even when viral replication is controlled through antiretroviral therapy (ART), experience persistent inflammation. This inflammation is partly attributed to intestinal microbial dysbiosis and translocation, which may lead to non-AIDS-related aging-associated comorbidities. The extent to which living …
us, es, nl
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Accès ouvert
2023
preprint
OpenAlex
Shalini Singh, Leila B. Giron, Maliha Shaikh, Shivanjali Shankaran et autres
Abstract Background People with HIV (PWH), even with controlled viral replication through antiretroviral therapy (ART), experience persistent inflammation. This is partly due to intestinal microbial dysbiosis and translocation. Such ongoing inflammation may lead to the development of non-AIDS-related aging-associated comorbidities. However, there …
us, es, nl
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Accès ouvert
2023
article
OpenAlex
Benjamin B. Policicchio, E. Fabián Cardozo-Ojeda, Cuiling Xu, Dongzhu Ma et autres
Abstract Whether CD8 + T lymphocytes control human immunodeficiency virus infection by cytopathic or non-cytopathic mechanisms is not fully understood. Multiple studies highlighted non-cytopathic effects, but one hypothesis is that cytopathic effects of CD8 + T cells occur before viral production. Here, …
us, pt
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Accès ouvert
2023
article
OpenAlex
Muhammad S. Khan, Eun Kim, Quentin Le Hingrat, Adam J. Kleinman et autres
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need for safe and effective vaccines to be rapidly developed and distributed worldwide, especially considering the emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Protein subunit vaccines have emerged …
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Accès ouvert
2023
article
OpenAlex
Cristian Apetrei, Thaidra Gaufin, Egidio Brocca‐Cofano, Ranjit Sivanandham et autres
Resolution of T cell activation and inflammation is a key determinant of the lack of SIV disease progression in African green monkeys (AGMs). Although frequently considered together, T cell activation occurs in response to viral stimulation of acquired immunity, while inflammation reflects …
us
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