Accès ouvert
2026
preprint
OpenAlex
Paul J. Sapienza, Trevor R. Mileur, Muhammad S. Khan, Kelin Li et autres
Abstract Positive cooperativity in ligand binding is a hallmark of allosteric oligomers, yet how the first binding event enhances the second remains obscure, because the pivotal singly-bound intermediate (lig₁) is thermodynamically disfavored and rarely accumulates. Distinguishing concerted (MWC) from sequential (KNF) mechanisms …
us
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Accès ouvert
2025
article
OpenAlex
Eun Kim, Muhammad S. Khan, Juyeop Shin, Shaohua Huang et autres
BACKGROUND/OBJECTIVES: COVID-19 vaccines effectively prevent severe disease, but unequal distribution, especially in low- and middle-income countries, has led to vaccine-resistant strains. This highlights the urgent need for alternative vaccine platforms that are safe, thermostable, and easy to distribute. This study evaluates the …
us, it
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Accès ouvert
2024
article
OpenAlex
Eun Kim, Juyeop Shin, Alessandro Ferrari, Shaohua Huang et autres
us, it
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Accès ouvert
2023
article
OpenAlex
Muhammad S. Khan, Eun Kim, Quentin Le Hingrat, Adam J. Kleinman et autres
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need for safe and effective vaccines to be rapidly developed and distributed worldwide, especially considering the emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Protein subunit vaccines have emerged …
us, it
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Accès ouvert
2023
article
OpenAlex
Eun Kim, Muhammad S. Khan, Alessandro Ferrari, Shaohua Huang et autres
Vaccines have significantly reduced the incidences of severe coronavirus disease 2019 (COVID-19) cases and deaths. However, the emergence of SARS-CoV-2 variants has raised concerns about their increased transmissibility and ability to evade neutralizing antibodies, especially among elderly individuals who are at higher …
us, it
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Accès ouvert
2023
preprint
OpenAlex
Muhammad S. Khan, Eun Kim, Quentin Le Hingrat, Adam J. Kleinman et autres
Abstract The COVID-19 pandemic has highlighted the need for safe and effective vaccines to be rapidly developed and distributed worldwide, especially considering the emergence of new SARS-CoV-2 variants. Protein subunit vaccines have emerged as a promising approach due to their proven safety …
us, it
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Muhammad S. Khan, Eun Sun Kim, Shaohua Huang, Thomas W. Kenniston et autres
This paper presents a novel approach for improving the efficacy of COVID-19 vaccines against emergent SARS-CoV-2 variants. We have evaluated the immunogenicity of unadjuvanted wild-type (WU S1-RS09cg) and variant-specific (Delta S1-RS09cg and OM S1-RS09cg) S1 subunit protein vaccines delivered either as a …
us
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Accès ouvert
2022
preprint
OpenAlex
Muhammad S. Khan, Eun Kim, Shaohua Huang, Thomas W. Kenniston et autres
Abstract This paper presents a novel approach for improving the efficacy of COVID-19 vaccines against emergent SARS-CoV-2 variants. We have evaluated the immunogenicity of unadjuvanted wild-type (WU S1-RS09cg) and variant-specific (Delta S1-RS09cg and OM S1-RS09cg) S1 subunit protein vaccines delivered either as …
us
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Accès ouvert
2022
preprint
OpenAlex
Eun Yi Kim, Muhammad S. Khan, Alessandro Ferrari, Shaohua Huang et autres
Abstract Currently approved COVID-19 vaccines prevent symptomatic infection, hospitalization, and death of the disease. However, the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants raises concerns of reduced vaccine effectiveness and increased risk of infection. Repeated homologous booster in elderly …
us, it
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Accès ouvert
2022
article
OpenAlex
Muhammad S. Khan, Eun Young Kim, Alex C. McPherson, Florian J. Weisel et autres
Abstract Additional COVID-19 vaccines that are safe and immunogenic are needed for global vaccine equity. Here, we developed a recombinant type 5 adenovirus vector encoding for the SARS-CoV-2 S1 subunit antigen and nucleocapsid as a fusion protein (Ad5.SARS-CoV-2-S1N). A single subcutaneous immunization …
us, fr, it, sk
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Accès ouvert
2022
preprint
OpenAlex
Muhammad S. Khan, Eun Ran Kim, Alex C. McPherson, Florian J. Weisel et autres
Abstract Additional COVID-19 vaccines that are safe, easy to manufacture, and immunogenic are needed for global vaccine equity. Here, we developed a recombinant type 5 adenovirus vector encoding for the SARS-CoV-2-S1 subunit antigen and nucleocapsid as a fusion protein (Ad5.SARS-CoV-2-S1N) delivered to …
us, it
(code pays fourni par la source)
2022
article
OpenAlex
Gary R. Hix, Muhammad S. Khan, Mikayla T. Miller, Elisha C. Napier et autres
A polyhydroxybutyrate (PHB)-degrading actinomycete, strain SFB5AT, was identified as a species of Streptomyces based on its membrane fatty acid profile and the presence of ll-diaminopimelic acid in the cell wall. It formed sporulating mycelia on most agar media, but flat or wrinkled, …
us
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