Shalini Singh

Inhibiting glycan degradation prevents HIV-induced inflammaging and cognitive impairment

Leila B. Giron, Alejandra Borjabad, Eran Hadas, Janeway Granche et autres

BACKGROUND: Cognitive impairment is a frequent outcome of chronic viral infections linked to premature aging, including HIV. The mechanisms underlying this decline remain poorly understood. Here, we identify pro-inflammatory glycan degradation, characterized by loss of sialic acid and galactose, both hallmarks of …

us, jp (code pays fourni par la source)

Intranasal curcumin mitigates paraquat-induced oxidative lung damage via involvement of neutrophil extracellular traps (NETs) in mice model

Shalini Singh, Diksha Sharma, Debabrata Dash, Singh Rh

in (code pays fourni par la source)

An overview of lead toxicity and its therapeutic strategies

Pushkar Singh Rawat, Shalini Singh

in (code pays fourni par la source)

Chemical composition and properties of aquatic food industry waste

Krishnendu Chakrabarty, Sunita Acharya, Niloy Chatterjee, Shalini Singh et autres

in, us, ph (code pays fourni par la source)

HIV-induced sialoglycans on infected CD4+ T cells promote immune evasion from myeloid cell-mediated killing

Shalini Singh, Shayla Islam, Rui Liu, Opeyemi S. Adeniji et autres

Sialic acid-containing glycans (sialoglycans) on pathological cells interact with Siglecs, glyco-immune checkpoint receptors expressed on myeloid cells, suppressing the cytotoxic functions of these immune cells. Using targeted glycomic analyses and gene editing, we show that HIV infection reprograms the glycosylation machinery of …

us, jp (code pays fourni par la source)

Prepandemic Metabolic Correlates of Coronavirus Disease 2019 (COVID-19) Severity and Long COVID Incidence in People Living With HIV

Priyesh Agrawal, Shalini Singh, Nel Jason Haw, Seble Kassaye et autres

Host metabolic dysregulation, especially in tryptophan metabolism, is intricately linked to coronavirus disease 2019 (COVID-19) severity and its postacute sequelae (long COVID). People living with human immunodeficiency virus (HIV; PLWH) experience similar metabolic dysregulation and face an increased risk of developing long …

us (code pays fourni par la source)

Strategic Integration of Artificial Intelligence in Disease Management

Pushkar Singh Rawat, Shalini Singh

The increasing global prevalence of disease, especially chronic illnesses, poses considerable challenges for healthcare systems and economies around the world. Artificial intelligence (AI) has emerged as a groundbreaking technology that could transform disease management by providing innovative solutions in various healthcare domains. …

Pre-pandemic Metabolic Correlates of COVID-19 Severity and Long COVID Incidence in People Living with HIV

Leila B. Giron, Aaron R. Goldman, Alan Landay, Nel Jason Haw et autres

Host metabolic dysregulation, especially in tryptophan metabolism, is intricately linked to COVID-19 severity and its post-acute sequelae (Long COVID). People living with HIV (PLWH) experience similar metabolic dysregulation and face an increased risk of developing Long COVID. However, whether pre-existing HIV-associated metabolic …

us (code pays fourni par la source)

Design and Studies of Multifunctional Hydroxypyridinone‐Based Biomimetic Chelators for Iron Coordination: A Density Functional Theory Approach

Shalini Singh, B. K. Kanungo, Minati Baral

Abstract Hydroxypyridinones and their derivatives possess a wide spectrum of therapeutic applications, such as anti‐inflammatory, antifungal, antioxidant, anticancer, and others, and are used in chelation therapy. Anchoring more hydroxypyridinone units into a single ligand moiety can boost the chelating property of the …

in (code pays fourni par la source)

Compromised Intestinal Barrier Resilience to Disruption in People With HIV

Maliha Shaikh, Shalini Singh, Leila B. Giron, Lijuan Zhang et autres

People with HIV (PWH) experience chronic intestinal barrier dysfunction, which contributes to chronic inflammation and its comorbidities. The mechanisms underlying this phenomenon remain unclear. We hypothesize that living with HIV compromises the intestinal barrier's resilience to injurious agents, increasing susceptibility to leakage …

us (code pays fourni par la source)

HIV-Induced Sialoglycans on Infected Cells Promote Immune Evasion from Myeloid Cell-Mediated Killing

Shalini Singh, Shayla Islam, Rui Liu, Opeyemi S. Adeniji et autres

Sialic acid-containing glycans (sialoglycans) on pathological cells interact with Siglecs, glycol-immune checkpoint receptors expressed on myeloid cells such as monocytes and neutrophils. This interaction suppresses the cytotoxic functions of these immune cells. We show that HIV infection reprograms the glycosylation machinery of …

us, Afrique du Sud (code pays fourni par la source)

Endocrine Responses to Foodborne Challenges

Diksha Singh, Shalini Singh

in, se (code pays fourni par la source)